Several treatments more effective in distinctive signatures: (TC1, AR- & TP53-); (TC2, TEfus+); (TC3 and TC4, HRD+); (TC5,PI3K )
| signature | var | Other | TC1 | TC2 | TC3 | TC4 | TC5 |
|---|---|---|---|---|---|---|---|
| all | param | scale = 0.112, shape = 1.05 | scale = 0.086, shape = 1.05 | scale = 0.132, shape = 1.05 | scale = 0.133, shape = 1.05 | scale = 0.178, shape = 1.05 | scale = 0.128, shape = 1.05 |
| all | summary | mean = 8.8, median = 6.3 | mean = 11.4, median = 8.2 | mean = 7.4, median = 5.3 | mean = 7.4, median = 5.3 | mean = 5.5, median = 4 | mean = 7.7, median = 5.5 |
| all | effect | af = 1, hr = 1 | af = 1.29, hr = 0.76 | af = 0.84, hr = 1.19 | af = 0.84, hr = 1.21 | af = 0.63, hr = 1.63 | af = 0.88, hr = 1.15 |
| AR- & TP53- | param | scale = 0.112, shape = 1.05 | scale = 0.05, shape = 1.05 | scale = 0.159, shape = 1.05 | scale = 0.132, shape = 1.05 | scale = 0.18, shape = 1.05 | scale = 0.149, shape = 1.05 |
| AR- & TP53- | summary | mean = 8.8, median = 6.3 | mean = 19.8, median = 14.2 | mean = 6.2, median = 4.4 | mean = 7.4, median = 5.3 | mean = 5.5, median = 3.9 | mean = 6.6, median = 4.7 |
| AR- & TP53- | effect | af = 1, hr = 1 | af = 2.25, hr = 0.43 | af = 0.7, hr = 1.45 | af = 0.84, hr = 1.2 | af = 0.62, hr = 1.65 | af = 0.75, hr = 1.35 |
| HRD+ | param | scale = 0.112, shape = 1.05 | scale = 0.086, shape = 1.05 | scale = 0.135, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.153, shape = 1.05 |
| HRD+ | summary | mean = 8.8, median = 6.3 | mean = 11.4, median = 8.2 | mean = 7.2, median = 5.2 | mean = 25, median = 18 | mean = 25, median = 18 | mean = 6.4, median = 4.6 |
| HRD+ | effect | af = 1, hr = 1 | af = 1.3, hr = 0.76 | af = 0.82, hr = 1.23 | af = 2.85, hr = 0.33 | af = 2.85, hr = 0.33 | af = 0.73, hr = 1.39 |
| TP53+ | param | scale = 0.112, shape = 1.05 | scale = 0.133, shape = 1.05 | scale = 0.095, shape = 1.05 | scale = 0.14, shape = 1.05 | scale = 0.184, shape = 1.05 | scale = 0.09, shape = 1.05 |
| TP53+ | summary | mean = 8.8, median = 6.3 | mean = 7.4, median = 5.3 | mean = 10.4, median = 7.5 | mean = 7, median = 5 | mean = 5.3, median = 3.8 | mean = 10.9, median = 7.8 |
| TP53+ | effect | af = 1, hr = 1 | af = 0.84, hr = 1.2 | af = 1.18, hr = 0.84 | af = 0.79, hr = 1.27 | af = 0.61, hr = 1.69 | af = 1.24, hr = 0.8 |
| TEfus+ | param | scale = 0.112, shape = 1.05 | scale = 0.116, shape = 1.05 | scale = 0.049, shape = 1.05 | scale = 0.135, shape = 1.05 | scale = 0.183, shape = 1.05 | scale = 0.107, shape = 1.05 |
| TEfus+ | summary | mean = 8.8, median = 6.3 | mean = 8.4, median = 6.1 | mean = 19.9, median = 14.3 | mean = 7.3, median = 5.2 | mean = 5.4, median = 3.9 | mean = 9.1, median = 6.6 |
| TEfus+ | effect | af = 1, hr = 1 | af = 0.96, hr = 1.04 | af = 2.27, hr = 0.42 | af = 0.83, hr = 1.22 | af = 0.61, hr = 1.68 | af = 1.04, hr = 0.96 |
| PI3K+ | param | scale = 0.112, shape = 1.05 | scale = 0.107, shape = 1.05 | scale = 0.117, shape = 1.05 | scale = 0.145, shape = 1.05 | scale = 0.198, shape = 1.05 | scale = 0.038, shape = 1.05 |
| PI3K+ | summary | mean = 8.8, median = 6.3 | mean = 9.2, median = 6.6 | mean = 8.4, median = 6 | mean = 6.8, median = 4.9 | mean = 5, median = 3.6 | mean = 26.1, median = 18.8 |
| PI3K+ | effect | af = 1, hr = 1 | af = 1.04, hr = 0.96 | af = 0.96, hr = 1.05 | af = 0.77, hr = 1.31 | af = 0.56, hr = 1.83 | af = 2.97, hr = 0.32 |
| subtype | var | Other | TC1 | TC2 | TC3 | TC4 | TC5 |
|---|---|---|---|---|---|---|---|
| —– | param | scale = 0.112, shape = 1.05 | scale = 0.042, shape = 1.05 | scale = 0.182, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.216, shape = 1.05 | scale = 0.182, shape = 1.05 |
| —– | summary | mean = 8.8, median = 6.3 | mean = 23.4, median = 16.9 | mean = 5.4, median = 3.9 | mean = 6.3, median = 4.5 | mean = 4.5, median = 3.3 | mean = 5.4, median = 3.9 |
| —– | effect | af = 1, hr = 1 | af = 2.67, hr = 0.36 | af = 0.61, hr = 1.67 | af = 0.71, hr = 1.43 | af = 0.52, hr = 2 | af = 0.61, hr = 1.67 |
| —-+ | param | scale = 0.112, shape = 1.05 | scale = 0.05, shape = 1.05 | scale = 0.182, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.216, shape = 1.05 | scale = 0.037, shape = 1.05 |
| —-+ | summary | mean = 8.8, median = 6.3 | mean = 19.4, median = 14 | mean = 5.4, median = 3.9 | mean = 6.3, median = 4.5 | mean = 4.5, median = 3.3 | mean = 26.6, median = 19.1 |
| —-+ | effect | af = 1, hr = 1 | af = 2.21, hr = 0.43 | af = 0.61, hr = 1.67 | af = 0.71, hr = 1.43 | af = 0.52, hr = 2 | af = 3.03, hr = 0.31 |
| —+- | param | scale = 0.112, shape = 1.05 | scale = 0.058, shape = 1.05 | scale = 0.042, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.216, shape = 1.05 | scale = 0.182, shape = 1.05 |
| —+- | summary | mean = 8.8, median = 6.3 | mean = 17, median = 12.2 | mean = 23.4, median = 16.9 | mean = 6.3, median = 4.5 | mean = 4.5, median = 3.3 | mean = 5.4, median = 3.9 |
| —+- | effect | af = 1, hr = 1 | af = 1.94, hr = 0.5 | af = 2.67, hr = 0.36 | af = 0.71, hr = 1.43 | af = 0.52, hr = 2 | af = 0.61, hr = 1.67 |
| —++ | param | scale = 0.112, shape = 1.05 | scale = 0.064, shape = 1.05 | scale = 0.05, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.216, shape = 1.05 | scale = 0.037, shape = 1.05 |
| —++ | summary | mean = 8.8, median = 6.3 | mean = 15.4, median = 11.1 | mean = 19.4, median = 14 | mean = 6.3, median = 4.5 | mean = 4.5, median = 3.3 | mean = 26.6, median = 19.1 |
| —++ | effect | af = 1, hr = 1 | af = 1.75, hr = 0.56 | af = 2.21, hr = 0.43 | af = 0.71, hr = 1.43 | af = 0.52, hr = 2 | af = 3.03, hr = 0.31 |
| –+– | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| –+– | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| –+– | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| –+-+ | param | scale = 0.112, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.182, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.216, shape = 1.05 | scale = 0.037, shape = 1.05 |
| –+-+ | summary | mean = 8.8, median = 6.3 | mean = 7.1, median = 5.1 | mean = 5.4, median = 3.9 | mean = 6.3, median = 4.5 | mean = 4.5, median = 3.3 | mean = 26.6, median = 19.1 |
| –+-+ | effect | af = 1, hr = 1 | af = 0.81, hr = 1.25 | af = 0.61, hr = 1.67 | af = 0.71, hr = 1.43 | af = 0.52, hr = 2 | af = 3.03, hr = 0.31 |
| –++- | param | scale = 0.112, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.216, shape = 1.05 | scale = 0.182, shape = 1.05 |
| –++- | summary | mean = 8.8, median = 6.3 | mean = 7.1, median = 5.1 | mean = 25, median = 18 | mean = 6.3, median = 4.5 | mean = 4.5, median = 3.3 | mean = 5.4, median = 3.9 |
| –++- | effect | af = 1, hr = 1 | af = 0.81, hr = 1.25 | af = 2.85, hr = 0.33 | af = 0.71, hr = 1.43 | af = 0.52, hr = 2 | af = 0.61, hr = 1.67 |
| –+++ | param | scale = 0.112, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.05, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.216, shape = 1.05 | scale = 0.037, shape = 1.05 |
| –+++ | summary | mean = 8.8, median = 6.3 | mean = 7.1, median = 5.1 | mean = 19.4, median = 14 | mean = 6.3, median = 4.5 | mean = 4.5, median = 3.3 | mean = 26.6, median = 19.1 |
| –+++ | effect | af = 1, hr = 1 | af = 0.81, hr = 1.25 | af = 2.21, hr = 0.43 | af = 0.71, hr = 1.43 | af = 0.52, hr = 2 | af = 3.03, hr = 0.31 |
| -+— | param | scale = 0.112, shape = 1.05 | scale = 0.058, shape = 1.05 | scale = 0.182, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.182, shape = 1.05 |
| -+— | summary | mean = 8.8, median = 6.3 | mean = 17, median = 12.2 | mean = 5.4, median = 3.9 | mean = 25, median = 18 | mean = 25, median = 18 | mean = 5.4, median = 3.9 |
| -+— | effect | af = 1, hr = 1 | af = 1.94, hr = 0.5 | af = 0.61, hr = 1.67 | af = 2.85, hr = 0.33 | af = 2.85, hr = 0.33 | af = 0.61, hr = 1.67 |
| -+–+ | param | scale = 0.112, shape = 1.05 | scale = 0.058, shape = 1.05 | scale = 0.182, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.039, shape = 1.05 |
| -+–+ | summary | mean = 8.8, median = 6.3 | mean = 17, median = 12.2 | mean = 5.4, median = 3.9 | mean = 25, median = 18 | mean = 25, median = 18 | mean = 25, median = 18 |
| -+–+ | effect | af = 1, hr = 1 | af = 1.94, hr = 0.5 | af = 0.61, hr = 1.67 | af = 2.85, hr = 0.33 | af = 2.85, hr = 0.33 | af = 2.85, hr = 0.33 |
| -+-+- | param | scale = 0.112, shape = 1.05 | scale = 0.071, shape = 1.05 | scale = 0.058, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.182, shape = 1.05 |
| -+-+- | summary | mean = 8.8, median = 6.3 | mean = 13.8, median = 9.9 | mean = 17, median = 12.2 | mean = 25, median = 18 | mean = 25, median = 18 | mean = 5.4, median = 3.9 |
| -+-+- | effect | af = 1, hr = 1 | af = 1.56, hr = 0.62 | af = 1.94, hr = 0.5 | af = 2.85, hr = 0.33 | af = 2.85, hr = 0.33 | af = 0.61, hr = 1.67 |
| -+-++ | param | scale = 0.112, shape = 1.05 | scale = 0.071, shape = 1.05 | scale = 0.058, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.039, shape = 1.05 |
| -+-++ | summary | mean = 8.8, median = 6.3 | mean = 13.8, median = 9.9 | mean = 17, median = 12.2 | mean = 25, median = 18 | mean = 25, median = 18 | mean = 25, median = 18 |
| -+-++ | effect | af = 1, hr = 1 | af = 1.56, hr = 0.62 | af = 1.94, hr = 0.5 | af = 2.85, hr = 0.33 | af = 2.85, hr = 0.33 | af = 2.85, hr = 0.33 |
| -++– | param | scale = 0.112, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.182, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.182, shape = 1.05 |
| -++– | summary | mean = 8.8, median = 6.3 | mean = 7.1, median = 5.1 | mean = 5.4, median = 3.9 | mean = 25, median = 18 | mean = 25, median = 18 | mean = 5.4, median = 3.9 |
| -++– | effect | af = 1, hr = 1 | af = 0.81, hr = 1.25 | af = 0.61, hr = 1.67 | af = 2.85, hr = 0.33 | af = 2.85, hr = 0.33 | af = 0.61, hr = 1.67 |
| -++-+ | param | scale = 0.112, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.182, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.039, shape = 1.05 |
| -++-+ | summary | mean = 8.8, median = 6.3 | mean = 7.1, median = 5.1 | mean = 5.4, median = 3.9 | mean = 25, median = 18 | mean = 25, median = 18 | mean = 25, median = 18 |
| -++-+ | effect | af = 1, hr = 1 | af = 0.81, hr = 1.25 | af = 0.61, hr = 1.67 | af = 2.85, hr = 0.33 | af = 2.85, hr = 0.33 | af = 2.85, hr = 0.33 |
| -+++- | param | scale = 0.112, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.058, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.182, shape = 1.05 |
| -+++- | summary | mean = 8.8, median = 6.3 | mean = 7.1, median = 5.1 | mean = 17, median = 12.2 | mean = 25, median = 18 | mean = 25, median = 18 | mean = 5.4, median = 3.9 |
| -+++- | effect | af = 1, hr = 1 | af = 0.81, hr = 1.25 | af = 1.94, hr = 0.5 | af = 2.85, hr = 0.33 | af = 2.85, hr = 0.33 | af = 0.61, hr = 1.67 |
| -++++ | param | scale = 0.112, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.058, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.039, shape = 1.05 |
| -++++ | summary | mean = 8.8, median = 6.3 | mean = 7.1, median = 5.1 | mean = 17, median = 12.2 | mean = 25, median = 18 | mean = 25, median = 18 | mean = 25, median = 18 |
| -++++ | effect | af = 1, hr = 1 | af = 0.81, hr = 1.25 | af = 1.94, hr = 0.5 | af = 2.85, hr = 0.33 | af = 2.85, hr = 0.33 | af = 2.85, hr = 0.33 |
| +—- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| +—- | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| +—- | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| +—+ | param | scale = 0.112, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.182, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.216, shape = 1.05 | scale = 0.039, shape = 1.05 |
| +—+ | summary | mean = 8.8, median = 6.3 | mean = 7.1, median = 5.1 | mean = 5.4, median = 3.9 | mean = 6.3, median = 4.5 | mean = 4.5, median = 3.3 | mean = 25, median = 18 |
| +—+ | effect | af = 1, hr = 1 | af = 0.81, hr = 1.25 | af = 0.61, hr = 1.67 | af = 0.71, hr = 1.43 | af = 0.52, hr = 2 | af = 2.85, hr = 0.33 |
| +–+- | param | scale = 0.112, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.216, shape = 1.05 | scale = 0.182, shape = 1.05 |
| +–+- | summary | mean = 8.8, median = 6.3 | mean = 7.1, median = 5.1 | mean = 25, median = 18 | mean = 6.3, median = 4.5 | mean = 4.5, median = 3.3 | mean = 5.4, median = 3.9 |
| +–+- | effect | af = 1, hr = 1 | af = 0.81, hr = 1.25 | af = 2.85, hr = 0.33 | af = 0.71, hr = 1.43 | af = 0.52, hr = 2 | af = 0.61, hr = 1.67 |
| +–++ | param | scale = 0.112, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.058, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.216, shape = 1.05 | scale = 0.039, shape = 1.05 |
| +–++ | summary | mean = 8.8, median = 6.3 | mean = 7.1, median = 5.1 | mean = 17, median = 12.2 | mean = 6.3, median = 4.5 | mean = 4.5, median = 3.3 | mean = 25, median = 18 |
| +–++ | effect | af = 1, hr = 1 | af = 0.81, hr = 1.25 | af = 1.94, hr = 0.5 | af = 0.71, hr = 1.43 | af = 0.52, hr = 2 | af = 2.85, hr = 0.33 |
| +-+– | param | scale = 0.112, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.182, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.216, shape = 1.05 | scale = 0.182, shape = 1.05 |
| +-+– | summary | mean = 8.8, median = 6.3 | mean = 7.1, median = 5.1 | mean = 5.4, median = 3.9 | mean = 6.3, median = 4.5 | mean = 4.5, median = 3.3 | mean = 5.4, median = 3.9 |
| +-+– | effect | af = 1, hr = 1 | af = 0.81, hr = 1.25 | af = 0.61, hr = 1.67 | af = 0.71, hr = 1.43 | af = 0.52, hr = 2 | af = 0.61, hr = 1.67 |
| +-+-+ | param | scale = 0.112, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.182, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.216, shape = 1.05 | scale = 0.039, shape = 1.05 |
| +-+-+ | summary | mean = 8.8, median = 6.3 | mean = 7.1, median = 5.1 | mean = 5.4, median = 3.9 | mean = 6.3, median = 4.5 | mean = 4.5, median = 3.3 | mean = 25, median = 18 |
| +-+-+ | effect | af = 1, hr = 1 | af = 0.81, hr = 1.25 | af = 0.61, hr = 1.67 | af = 0.71, hr = 1.43 | af = 0.52, hr = 2 | af = 2.85, hr = 0.33 |
| +-++- | param | scale = 0.112, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.216, shape = 1.05 | scale = 0.182, shape = 1.05 |
| +-++- | summary | mean = 8.8, median = 6.3 | mean = 7.1, median = 5.1 | mean = 25, median = 18 | mean = 6.3, median = 4.5 | mean = 4.5, median = 3.3 | mean = 5.4, median = 3.9 |
| +-++- | effect | af = 1, hr = 1 | af = 0.81, hr = 1.25 | af = 2.85, hr = 0.33 | af = 0.71, hr = 1.43 | af = 0.52, hr = 2 | af = 0.61, hr = 1.67 |
| +-+++ | param | scale = 0.112, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.058, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.216, shape = 1.05 | scale = 0.039, shape = 1.05 |
| +-+++ | summary | mean = 8.8, median = 6.3 | mean = 7.1, median = 5.1 | mean = 17, median = 12.2 | mean = 6.3, median = 4.5 | mean = 4.5, median = 3.3 | mean = 25, median = 18 |
| +-+++ | effect | af = 1, hr = 1 | af = 0.81, hr = 1.25 | af = 1.94, hr = 0.5 | af = 0.71, hr = 1.43 | af = 0.52, hr = 2 | af = 2.85, hr = 0.33 |
| ++— | param | scale = 0.112, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.182, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.182, shape = 1.05 |
| ++— | summary | mean = 8.8, median = 6.3 | mean = 7.1, median = 5.1 | mean = 5.4, median = 3.9 | mean = 25, median = 18 | mean = 25, median = 18 | mean = 5.4, median = 3.9 |
| ++— | effect | af = 1, hr = 1 | af = 0.81, hr = 1.25 | af = 0.61, hr = 1.67 | af = 2.85, hr = 0.33 | af = 2.85, hr = 0.33 | af = 0.61, hr = 1.67 |
| ++–+ | param | scale = 0.112, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.182, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.039, shape = 1.05 |
| ++–+ | summary | mean = 8.8, median = 6.3 | mean = 7.1, median = 5.1 | mean = 5.4, median = 3.9 | mean = 25, median = 18 | mean = 25, median = 18 | mean = 25, median = 18 |
| ++–+ | effect | af = 1, hr = 1 | af = 0.81, hr = 1.25 | af = 0.61, hr = 1.67 | af = 2.85, hr = 0.33 | af = 2.85, hr = 0.33 | af = 2.85, hr = 0.33 |
| ++-+- | param | scale = 0.112, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.058, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.182, shape = 1.05 |
| ++-+- | summary | mean = 8.8, median = 6.3 | mean = 7.1, median = 5.1 | mean = 17, median = 12.2 | mean = 25, median = 18 | mean = 25, median = 18 | mean = 5.4, median = 3.9 |
| ++-+- | effect | af = 1, hr = 1 | af = 0.81, hr = 1.25 | af = 1.94, hr = 0.5 | af = 2.85, hr = 0.33 | af = 2.85, hr = 0.33 | af = 0.61, hr = 1.67 |
| ++-++ | param | scale = 0.112, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.058, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.039, shape = 1.05 |
| ++-++ | summary | mean = 8.8, median = 6.3 | mean = 7.1, median = 5.1 | mean = 17, median = 12.2 | mean = 25, median = 18 | mean = 25, median = 18 | mean = 25, median = 18 |
| ++-++ | effect | af = 1, hr = 1 | af = 0.81, hr = 1.25 | af = 1.94, hr = 0.5 | af = 2.85, hr = 0.33 | af = 2.85, hr = 0.33 | af = 2.85, hr = 0.33 |
| +++– | param | scale = 0.112, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.182, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.182, shape = 1.05 |
| +++– | summary | mean = 8.8, median = 6.3 | mean = 7.1, median = 5.1 | mean = 5.4, median = 3.9 | mean = 25, median = 18 | mean = 25, median = 18 | mean = 5.4, median = 3.9 |
| +++– | effect | af = 1, hr = 1 | af = 0.81, hr = 1.25 | af = 0.61, hr = 1.67 | af = 2.85, hr = 0.33 | af = 2.85, hr = 0.33 | af = 0.61, hr = 1.67 |
| +++-+ | param | scale = 0.112, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.182, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.039, shape = 1.05 |
| +++-+ | summary | mean = 8.8, median = 6.3 | mean = 7.1, median = 5.1 | mean = 5.4, median = 3.9 | mean = 25, median = 18 | mean = 25, median = 18 | mean = 25, median = 18 |
| +++-+ | effect | af = 1, hr = 1 | af = 0.81, hr = 1.25 | af = 0.61, hr = 1.67 | af = 2.85, hr = 0.33 | af = 2.85, hr = 0.33 | af = 2.85, hr = 0.33 |
| ++++- | param | scale = 0.112, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.064, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.182, shape = 1.05 |
| ++++- | summary | mean = 8.8, median = 6.3 | mean = 7.1, median = 5.1 | mean = 15.4, median = 11.1 | mean = 25, median = 18 | mean = 25, median = 18 | mean = 5.4, median = 3.9 |
| ++++- | effect | af = 1, hr = 1 | af = 0.81, hr = 1.25 | af = 1.75, hr = 0.56 | af = 2.85, hr = 0.33 | af = 2.85, hr = 0.33 | af = 0.61, hr = 1.67 |
| +++++ | param | scale = 0.112, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.064, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.039, shape = 1.05 |
| +++++ | summary | mean = 8.8, median = 6.3 | mean = 7.1, median = 5.1 | mean = 15.4, median = 11.1 | mean = 25, median = 18 | mean = 25, median = 18 | mean = 25, median = 18 |
| +++++ | effect | af = 1, hr = 1 | af = 0.81, hr = 1.25 | af = 1.75, hr = 0.56 | af = 2.85, hr = 0.33 | af = 2.85, hr = 0.33 | af = 2.85, hr = 0.33 |
|
|
|
|
|
|
| char | overall | TC1 | TC2 | TC3 | TC4 | TC5 |
|---|---|---|---|---|---|---|
| err_sign | 0.1182365 | 0.0320641 | 0.0400802 | 0.0100200 | 0.0020040 | 0.0360721 |
| err_type | 0.2024048 | 0.0460922 | 0.0621242 | 0.0100200 | 0.0020040 | 0.0941884 |
| pow_sign | 0.9478958 | 0.4829659 | 0.1823647 | 0.4569138 | 0.3947896 | 0.6152305 |
| pow_type | 0.9619238 | 0.5110220 | 0.2224449 | 0.4669339 | 0.3967936 | 0.6513026 |
| signature | var | Control | TC1 | TC2 | TC3 | TC4 | TC5 |
|---|---|---|---|---|---|---|---|
| all | graduation | 0 | 20 | 2 | 2 | 0 | 12 |
| all | futility | 0 | 0 | 0 | 0 | 4 | 0 |
| all | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| all | n | 426 (399, 453) | 188 (81, 236) | 160 (103, 210) | 151 (97, 219) | 114 (86, 168) | 141 (85, 217) |
| all | n_unique | 392 (369, 417) | 176 (74, 221) | 145 (93, 195) | 138 (89, 204) | 103 (77, 152) | 128 (76, 201) |
| all | time_trial | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) |
| all | time_stop | NA (NA, NA) | 5 (4, 8) | 6 (4, 7) | 6 (6, 7) | 10 (8, 14) | 6 (5, 10) |
| all | post_p | NA (NA, NA) | 1 (0.57, 1) | 0.88 (0.23, 1) | 0.21 (0, 0.82) | 0.21 (0, 0.78) | 0.96 (0.25, 1) |
| all | rate | 0.092 (0.085, 0.1) | 0.065 (0.054, 0.087) | 0.079 (0.067, 0.097) | 0.101 (0.083, 0.12) | 0.1 (0.083, 0.127) | 0.073 (0.056, 0.097) |
| AR- & TP53- | graduation | 0 | 241 | 0 | 3 | 1 | 1 |
| AR- & TP53- | futility | 0 | 1 | 60 | 19 | 34 | 3 |
| AR- & TP53- | max_n | 0 | 244 | 20 | 111 | 31 | 46 |
| AR- & TP53- | n | 260 (240, 285) | 150 (26, 155) | 57 (32, 100) | 87 (47, 153) | 59 (36, 103) | 69 (34, 143) |
| AR- & TP53- | n_unique | 242 (222, 264) | 137 (25, 149) | 51 (28, 92) | 80 (42, 146) | 53 (33, 96) | 63 (31, 134) |
| AR- & TP53- | time_trial | 36 (36, 36) | 36 (6, 36) | 36 (25, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) |
| AR- & TP53- | time_stop | NA (NA, NA) | 7 (5, 15) | 18 (12, 32) | 14 (11, 25) | 15 (10, 20) | 13 (10, 18) |
| AR- & TP53- | post_p | NA (NA, NA) | 1 (0.99, 1) | 0.1 (0, 0.53) | 0.34 (0, 0.92) | 0.46 (0, 0.93) | 0.5 (0.01, 0.97) |
| AR- & TP53- | rate | 0.085 (0.077, 0.094) | 0.045 (0.036, 0.053) | 0.112 (0.085, 0.149) | 0.092 (0.065, 0.121) | 0.085 (0.063, 0.131) | 0.083 (0.06, 0.125) |
| HRD+ | graduation | 0 | 2 | 0 | 228 | 197 | 0 |
| HRD+ | futility | 0 | 2 | 19 | 0 | 0 | 10 |
| HRD+ | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| HRD+ | n | 63 (52, 75) | 16 (7, 28) | 22 (14, 37) | 37 (25, 54) | 38 (25, 58) | 18 (11, 28) |
| HRD+ | n_unique | 58 (46, 68) | 14 (6, 25) | 20 (12, 32) | 34 (23, 50) | 35 (22, 53) | 16 (10, 25) |
| HRD+ | time_trial | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (19, 36) | 36 (20, 36) | 36 (36, 36) |
| HRD+ | time_stop | NA (NA, NA) | 31 (28, 33) | 35 (26, 35) | 24 (16, 32) | 24 (17, 33) | 32 (30, 35) |
| HRD+ | post_p | NA (NA, NA) | 0.48 (0.11, 0.87) | 0.31 (0.06, 0.8) | 1 (0.98, 1) | 1 (0.96, 1) | 0.17 (0.02, 0.58) |
| HRD+ | rate | 0.097 (0.078, 0.118) | 0.09 (0.061, 0.151) | 0.101 (0.07, 0.156) | 0.038 (0.028, 0.05) | 0.038 (0.028, 0.052) | 0.124 (0.082, 0.188) |
| TP53+ | graduation | 0 | 1 | 27 | 0 | 0 | 35 |
| TP53+ | futility | 0 | 122 | 0 | 87 | 126 | 0 |
| TP53+ | max_n | 0 | 0 | 0 | 0 | 0 | 1 |
| TP53+ | n | 137 (121, 153) | 50 (28, 77) | 81 (40, 109) | 45 (28, 66) | 37 (25, 58) | 55 (29, 96) |
| TP53+ | n_unique | 125 (109, 139) | 45 (25, 69) | 74 (37, 99) | 40 (26, 60) | 34 (23, 52) | 50 (26, 87) |
| TP53+ | time_trial | 36 (36, 36) | 36 (22, 36) | 36 (36, 36) | 36 (26, 36) | 36 (21, 36) | 36 (36, 36) |
| TP53+ | time_stop | NA (NA, NA) | 24 (16, 32) | 15 (11, 26) | 24 (17, 33) | 24 (16, 32) | 14 (11, 23) |
| TP53+ | post_p | NA (NA, NA) | 0.09 (0.01, 0.45) | 1 (0.89, 1) | 0.15 (0.02, 0.56) | 0.07 (0, 0.42) | 1 (0.88, 1) |
| TP53+ | rate | 0.103 (0.09, 0.12) | 0.133 (0.107, 0.166) | 0.064 (0.051, 0.08) | 0.127 (0.102, 0.158) | 0.142 (0.11, 0.189) | 0.057 (0.044, 0.078) |
| TEfus+ | graduation | 0 | 0 | 91 | 0 | 0 | 1 |
| TEfus+ | futility | 0 | 46 | 0 | 34 | 75 | 2 |
| TEfus+ | max_n | 0 | 0 | 1 | 0 | 0 | 0 |
| TEfus+ | n | 129 (113, 146) | 39 (25, 59) | 94 (31, 118) | 45 (32, 63) | 39 (27, 54) | 47 (28, 81) |
| TEfus+ | n_unique | 117 (102, 132) | 35 (22, 53) | 86 (29, 107) | 40 (29, 59) | 35 (25, 49) | 43 (25, 74) |
| TEfus+ | time_trial | 36 (36, 36) | 36 (36, 36) | 36 (15, 36) | 36 (36, 36) | 36 (26, 36) | 36 (36, 36) |
| TEfus+ | time_stop | NA (NA, NA) | 27 (18, 35) | 15 (11, 27) | 21 (15, 30) | 22 (15, 31) | 13 (12, 13) |
| TEfus+ | post_p | NA (NA, NA) | 0.08 (0, 0.41) | 1 (0.97, 1) | 0.18 (0.02, 0.63) | 0.08 (0, 0.47) | 0.88 (0.36, 1) |
| TEfus+ | rate | 0.082 (0.071, 0.094) | 0.111 (0.089, 0.145) | 0.046 (0.037, 0.057) | 0.1 (0.076, 0.129) | 0.112 (0.085, 0.157) | 0.063 (0.048, 0.086) |
| PI3K+ | graduation | 0 | 0 | 5 | 0 | 0 | 307 |
| PI3K+ | futility | 0 | 13 | 3 | 75 | 104 | 0 |
| PI3K+ | max_n | 0 | 0 | 0 | 0 | 0 | 4 |
| PI3K+ | n | 138 (120, 155) | 45 (25, 73) | 63 (34, 96) | 43 (27, 72) | 34 (25, 53) | 62 (27, 124) |
| PI3K+ | n_unique | 126 (109, 141) | 41 (21, 66) | 56 (32, 87) | 39 (24, 66) | 31 (22, 48) | 56 (25, 115) |
| PI3K+ | time_trial | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (26, 36) | 36 (21, 36) | 22 (11, 36) |
| PI3K+ | time_stop | NA (NA, NA) | 23 (15, 33) | 14 (12, 30) | 23 (17, 31) | 22 (16, 33) | 15 (10, 28) |
| PI3K+ | post_p | NA (NA, NA) | 0.47 (0.07, 0.9) | 0.84 (0.36, 0.99) | 0.11 (0.01, 0.53) | 0.04 (0, 0.32) | 1 (1, 1) |
| PI3K+ | rate | 0.097 (0.085, 0.112) | 0.096 (0.074, 0.132) | 0.079 (0.061, 0.102) | 0.123 (0.096, 0.161) | 0.144 (0.107, 0.194) | 0.037 (0.029, 0.046) |
| subtype | var | Control | TC1 | TC2 | TC3 | TC4 | TC5 |
|---|---|---|---|---|---|---|---|
| —– | graduation | 0 | 254 | 2 | 5 | 1 | 13 |
| —– | futility | 0 | 1 | 60 | 19 | 38 | 3 |
| —– | max_n | 0 | 244 | 20 | 111 | 31 | 46 |
| —– | n | 159 (140, 175) | 94 (20, 120) | 15 (8, 52) | 37 (10, 110) | 13 (7, 54) | 19 (8, 92) |
| —– | n_unique | 149 (131, 165) | 91 (20, 116) | 14 (7, 51) | 34 (9, 106) | 11 (6, 52) | 16 (7, 88) |
| —– | post_p | NA (NA, NA) | 1 (0.99, 1) | 0.02 (0, 0.07) | 0.02 (0, 0.13) | 0.01 (0, 0.06) | 0.01 (0, 0.08) |
| —– | rate | 0.086 (0.076, 0.098) | 0.041 (0.033, 0.051) | 0.195 (0.152, 0.308) | 0.165 (0.13, 0.239) | 0.235 (0.18, 0.383) | 0.196 (0.153, 0.295) |
| —-+ | graduation | 0 | 251 | 7 | 5 | 1 | 301 |
| —-+ | futility | 0 | 6 | 61 | 74 | 133 | 3 |
| —-+ | max_n | 0 | 242 | 20 | 108 | 29 | 44 |
| —-+ | n | 35 (27, 43) | 8 (1, 22) | 7 (3, 21) | 8 (3, 23) | 6 (3, 16) | 16 (6, 37) |
| —-+ | n_unique | 32 (25, 40) | 7 (1, 20) | 6 (3, 19) | 7 (3, 22) | 5 (2, 14) | 15 (6, 35) |
| —-+ | post_p | NA (NA, NA) | 0.87 (0.51, 0.99) | 0.14 (0.03, 0.35) | 0.18 (0.05, 0.43) | 0.13 (0.03, 0.29) | 0.99 (0.83, 1) |
| —-+ | rate | 0.092 (0.069, 0.126) | 0.05 (0.024, 0.096) | 0.198 (0.129, 0.402) | 0.166 (0.11, 0.344) | 0.246 (0.158, 0.498) | 0.038 (0.024, 0.06) |
| —+- | graduation | 0 | 235 | 84 | 5 | 1 | 13 |
| —+- | futility | 0 | 31 | 60 | 41 | 97 | 5 |
| —+- | max_n | 0 | 233 | 21 | 111 | 31 | 46 |
| —+- | n | 5 (2, 9) | 1 (0, 4) | 3 (1, 8) | 2 (1, 5) | 2 (0, 4) | 2 (1, 5) |
| —+- | n_unique | 5 (2, 8) | 1 (0, 4) | 3 (0, 7) | 2 (0, 4) | 2 (0, 4) | 2 (1, 5) |
| —+- | post_p | NA (NA, NA) | 0.53 (0.36, 0.81) | 0.68 (0.43, 0.87) | 0.37 (0.21, 0.55) | 0.34 (0.21, 0.47) | 0.35 (0.19, 0.52) |
| —+- | rate | 0.063 (0.025, 0.132) | 0.07 (0.02, 0.26) | 0.045 (0, 0.137) | 0.183 (0.081, 0.669) | 0.255 (0.117, 0.821) | 0.224 (0.085, 0.705) |
| —++ | graduation | 0 | 234 | 84 | 5 | 1 | 301 |
| —++ | futility | 0 | 33 | 61 | 89 | 167 | 5 |
| —++ | max_n | 0 | 232 | 21 | 108 | 29 | 44 |
| —++ | n | 15 (10, 21) | 3 (0, 9) | 8 (2, 16) | 4 (2, 9) | 4 (2, 7) | 6 (2, 15) |
| —++ | n_unique | 14 (9, 19) | 3 (0, 8) | 7 (2, 15) | 4 (2, 9) | 3 (1, 6) | 5 (2, 14) |
| —++ | post_p | NA (NA, NA) | 0.49 (0.26, 0.82) | 0.68 (0.34, 0.93) | 0.22 (0.09, 0.4) | 0.19 (0.06, 0.35) | 0.8 (0.46, 0.96) |
| —++ | rate | 0.067 (0.043, 0.103) | 0.073 (0.028, 0.187) | 0.052 (0.023, 0.123) | 0.182 (0.102, 0.473) | 0.248 (0.135, 0.6) | 0.037 (0.016, 0.084) |
| –+– | graduation | 0 | 21 | 29 | 2 | 0 | 46 |
| –+– | futility | 0 | 122 | 0 | 87 | 130 | 0 |
| –+– | max_n | 0 | 0 | 0 | 0 | 0 | 1 |
| –+– | n | 26 (19, 34) | 11 (4, 23) | 11 (4, 23) | 9 (4, 20) | 10 (4, 24) | 10 (3, 22) |
| –+– | n_unique | 23 (17, 31) | 10 (4, 21) | 10 (4, 21) | 9 (3, 19) | 9 (3, 22) | 8 (3, 20) |
| –+– | post_p | NA (NA, NA) | 0.49 (0.18, 0.85) | 0.46 (0.17, 0.82) | 0.44 (0.16, 0.83) | 0.48 (0.18, 0.85) | 0.48 (0.18, 0.84) |
| –+– | rate | 0.114 (0.086, 0.151) | 0.121 (0.08, 0.214) | 0.123 (0.083, 0.272) | 0.125 (0.082, 0.277) | 0.123 (0.081, 0.243) | 0.123 (0.077, 0.238) |
| –+-+ | graduation | 0 | 21 | 31 | 2 | 0 | 325 |
| –+-+ | futility | 0 | 128 | 3 | 126 | 173 | 0 |
| –+-+ | max_n | 0 | 0 | 0 | 0 | 0 | 5 |
| –+-+ | n | 29 (21, 36) | 9 (3, 25) | 6 (3, 19) | 7 (3, 21) | 5 (3, 13) | 13 (4, 31) |
| –+-+ | n_unique | 26 (19, 33) | 8 (3, 23) | 6 (3, 18) | 6 (3, 20) | 5 (2, 11) | 12 (4, 29) |
| –+-+ | post_p | NA (NA, NA) | 0.43 (0.16, 0.82) | 0.26 (0.11, 0.57) | 0.33 (0.12, 0.68) | 0.23 (0.11, 0.45) | 1 (0.95, 1) |
| –+-+ | rate | 0.144 (0.111, 0.19) | 0.151 (0.099, 0.37) | 0.201 (0.13, 0.432) | 0.181 (0.117, 0.451) | 0.241 (0.153, 0.538) | 0.037 (0.022, 0.062) |
| –++- | graduation | 0 | 21 | 111 | 2 | 0 | 46 |
| –++- | futility | 0 | 153 | 0 | 109 | 179 | 2 |
| –++- | max_n | 0 | 0 | 1 | 0 | 0 | 1 |
| –++- | n | 8 (4, 12) | 3 (1, 6) | 6 (2, 11) | 3 (1, 5) | 2 (1, 5) | 3 (1, 5) |
| –++- | n_unique | 7 (3, 11) | 3 (1, 6) | 5 (2, 10) | 3 (1, 5) | 2 (0, 4) | 2 (1, 5) |
| –++- | post_p | NA (NA, NA) | 0.39 (0.23, 0.62) | 0.83 (0.55, 0.97) | 0.38 (0.23, 0.58) | 0.33 (0.18, 0.48) | 0.35 (0.2, 0.51) |
| –++- | rate | 0.086 (0.044, 0.164) | 0.157 (0.078, 0.455) | 0.041 (0.012, 0.094) | 0.175 (0.079, 0.588) | 0.264 (0.118, 0.883) | 0.209 (0.105, 0.654) |
| –+++ | graduation | 0 | 21 | 110 | 2 | 0 | 325 |
| –+++ | futility | 0 | 158 | 3 | 144 | 209 | 2 |
| –+++ | max_n | 0 | 0 | 1 | 0 | 0 | 5 |
| –+++ | n | 22 (15, 29) | 5 (2, 13) | 14 (3, 24) | 5 (2, 12) | 4 (2, 7) | 9 (3, 23) |
| –+++ | n_unique | 20 (14, 27) | 5 (2, 12) | 13 (3, 22) | 4 (2, 10) | 3 (2, 6) | 8 (3, 22) |
| –+++ | post_p | NA (NA, NA) | 0.26 (0.1, 0.5) | 0.87 (0.51, 0.99) | 0.22 (0.1, 0.45) | 0.19 (0.08, 0.36) | 0.95 (0.62, 1) |
| –+++ | rate | 0.091 (0.065, 0.129) | 0.157 (0.094, 0.354) | 0.051 (0.028, 0.09) | 0.179 (0.107, 0.408) | 0.244 (0.14, 0.643) | 0.038 (0.018, 0.074) |
| -+— | graduation | 0 | 255 | 2 | 191 | 191 | 13 |
| -+— | futility | 0 | 3 | 79 | 18 | 36 | 12 |
| -+— | max_n | 0 | 241 | 20 | 104 | 24 | 46 |
| -+— | n | 28 (21, 37) | 4 (0, 12) | 5 (3, 11) | 16 (8, 28) | 17 (8, 30) | 5 (3, 13) |
| -+— | n_unique | 25 (18, 34) | 3 (0, 11) | 5 (2, 10) | 14 (8, 26) | 16 (7, 28) | 5 (2, 11) |
| -+— | post_p | NA (NA, NA) | 0.69 (0.35, 0.93) | 0.17 (0.06, 0.34) | 0.97 (0.72, 1) | 0.97 (0.74, 1) | 0.17 (0.06, 0.34) |
| -+— | rate | 0.096 (0.072, 0.138) | 0.061 (0.029, 0.172) | 0.202 (0.121, 0.437) | 0.039 (0.024, 0.067) | 0.038 (0.023, 0.064) | 0.204 (0.125, 0.41) |
| -+–+ | graduation | 0 | 252 | 7 | 180 | 179 | 297 |
| -+–+ | futility | 0 | 8 | 80 | 62 | 118 | 12 |
| -+–+ | max_n | 0 | 239 | 20 | 102 | 22 | 44 |
| -+–+ | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| -+–+ | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| -+–+ | post_p | NA (NA, NA) | 0.48 (0.48, 0.48) | 0.48 (0.48, 0.49) | NA (NA, NA) | 0.5 (0.5, 0.5) | NA (NA, NA) |
| -+–+ | rate | 0.191 (0, 0.698) | 0.159 (0, 0.381) | 0.283 (0.02, 0.817) | 0.06 (0, 0.141) | 0.063 (0, 0.287) | 0.064 (0, 0.157) |
| -+-+- | graduation | 0 | 236 | 84 | 190 | 185 | 13 |
| -+-+- | futility | 0 | 32 | 79 | 35 | 91 | 14 |
| -+-+- | max_n | 0 | 231 | 21 | 104 | 24 | 46 |
| -+-+- | n | 13 (8, 18) | 2 (0, 6) | 6 (2, 12) | 7 (3, 13) | 6 (2, 14) | 4 (2, 7) |
| -+-+- | n_unique | 12 (7, 17) | 2 (0, 6) | 5 (1, 11) | 6 (2, 12) | 6 (2, 13) | 3 (1, 7) |
| -+-+- | post_p | NA (NA, NA) | 0.47 (0.22, 0.73) | 0.55 (0.26, 0.85) | 0.76 (0.4, 0.95) | 0.73 (0.36, 0.94) | 0.21 (0.07, 0.38) |
| -+-+- | rate | 0.074 (0.044, 0.122) | 0.074 (0.032, 0.225) | 0.059 (0.027, 0.174) | 0.039 (0.016, 0.085) | 0.042 (0.02, 0.102) | 0.213 (0.109, 0.541) |
| -+-++ | graduation | 0 | 235 | 84 | 179 | 175 | 297 |
| -+-++ | futility | 0 | 34 | 80 | 73 | 150 | 14 |
| -+-++ | max_n | 0 | 230 | 21 | 102 | 22 | 44 |
| -+-++ | n | 5 (2, 9) | 1 (0, 3) | 3 (0, 6) | 3 (0, 6) | 3 (1, 5) | 1 (0, 5) |
| -+-++ | n_unique | 4 (2, 8) | 1 (0, 3) | 2 (0, 6) | 2 (0, 6) | 2 (0, 5) | 1 (0, 4) |
| -+-++ | post_p | NA (NA, NA) | 0.44 (0.3, 0.63) | 0.48 (0.31, 0.7) | 0.54 (0.35, 0.76) | 0.55 (0.36, 0.77) | 0.55 (0.37, 0.74) |
| -+-++ | rate | 0.078 (0.028, 0.182) | 0.087 (0.022, 0.299) | 0.062 (0.013, 0.215) | 0.043 (0.009, 0.123) | 0.043 (0, 0.128) | 0.04 (0, 0.152) |
| -++– | graduation | 0 | 23 | 29 | 213 | 177 | 44 |
| -++– | futility | 0 | 124 | 19 | 71 | 108 | 10 |
| -++– | max_n | 0 | 0 | 0 | 0 | 0 | 1 |
| -++– | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| -++– | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| -++– | post_p | NA (NA, NA) | 0.47 (0.44, 0.53) | 0.45 (0.43, 0.48) | 0.47 (0.43, 0.52) | 0.5 (0.5, 0.5) | 0.49 (0.47, 0.52) |
| -++– | rate | 0.129 (0, 0.997) | 0.101 (0, 0.528) | 0.475 (0.089, 3.106) | 0.056 (0, 2.733) | 0.035 (0, 0.494) | 0.189 (0, 1.078) |
| -++-+ | graduation | 0 | 23 | 31 | 203 | 171 | 319 |
| -++-+ | futility | 0 | 130 | 22 | 104 | 145 | 10 |
| -++-+ | max_n | 0 | 0 | 0 | 0 | 0 | 5 |
| -++-+ | n | 3 (1, 5) | 1 (0, 3) | 2 (0, 4) | 2 (0, 4) | 2 (0, 4) | 1 (0, 3) |
| -++-+ | n_unique | 2 (1, 5) | 1 (0, 3) | 1 (0, 3) | 1 (0, 4) | 1 (0, 4) | 1 (0, 3) |
| -++-+ | post_p | NA (NA, NA) | 0.45 (0.29, 0.58) | 0.42 (0.27, 0.55) | 0.6 (0.45, 0.79) | 0.58 (0.43, 0.78) | 0.58 (0.44, 0.79) |
| -++-+ | rate | 0.152 (0.053, 0.43) | 0.164 (0.019, 0.67) | 0.221 (0.083, 0.772) | 0.039 (0, 0.174) | 0.043 (0, 0.206) | 0.039 (0, 0.178) |
| -+++- | graduation | 0 | 23 | 111 | 212 | 172 | 44 |
| -+++- | futility | 0 | 154 | 19 | 90 | 153 | 12 |
| -+++- | max_n | 0 | 0 | 1 | 0 | 0 | 1 |
| -+++- | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| -+++- | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| -+++- | post_p | NA (NA, NA) | 0.53 (0.49, 0.56) | NA (NA, NA) | 0.46 (0.41, 0.51) | 0.49 (0.48, 0.53) | 0.51 (0.49, 0.53) |
| -+++- | rate | 0.138 (0, 0.548) | 0.143 (0, 3.254) | 0.081 (0, 0.239) | 0.039 (0, 0.207) | 0.077 (0, 0.324) | 0.167 (0, 5.454) |
| -++++ | graduation | 0 | 23 | 110 | 202 | 167 | 319 |
| -++++ | futility | 0 | 159 | 22 | 119 | 178 | 12 |
| -++++ | max_n | 0 | 0 | 1 | 0 | 0 | 5 |
| -++++ | n | 3 (1, 6) | 1 (0, 3) | 2 (0, 4) | 2 (0, 4) | 2 (0, 4) | 1 (0, 3) |
| -++++ | n_unique | 3 (1, 6) | 1 (0, 3) | 1 (0, 4) | 1 (0, 4) | 1 (0, 4) | 1 (0, 3) |
| -++++ | post_p | NA (NA, NA) | 0.42 (0.28, 0.55) | 0.52 (0.36, 0.7) | 0.56 (0.41, 0.75) | 0.56 (0.41, 0.74) | 0.54 (0.42, 0.71) |
| -++++ | rate | 0.104 (0.032, 0.315) | 0.17 (0.042, 0.755) | 0.064 (0, 0.265) | 0.04 (0, 0.175) | 0.04 (0, 0.171) | 0.045 (0, 0.18) |
| +—- | graduation | 0 | 20 | 2 | 2 | 0 | 12 |
| +—- | futility | 0 | 0 | 0 | 0 | 4 | 0 |
| +—- | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| +—- | n | 5 (2, 8) | 2 (1, 5) | 3 (1, 6) | 2 (1, 5) | 2 (1, 5) | 2 (0, 5) |
| +—- | n_unique | 4 (2, 7) | 2 (0, 5) | 3 (1, 6) | 2 (0, 5) | 2 (0, 5) | 2 (0, 4) |
| +—- | post_p | NA (NA, NA) | 0.46 (0.28, 0.7) | 0.48 (0.29, 0.76) | 0.46 (0.29, 0.72) | 0.49 (0.3, 0.73) | 0.47 (0.3, 0.74) |
| +—- | rate | 0.111 (0.055, 0.22) | 0.139 (0.053, 0.506) | 0.123 (0.055, 0.413) | 0.139 (0.041, 0.53) | 0.129 (0.013, 0.475) | 0.139 (0.04, 0.465) |
| +—+ | graduation | 0 | 20 | 7 | 2 | 0 | 316 |
| +—+ | futility | 0 | 13 | 3 | 75 | 108 | 0 |
| +—+ | max_n | 0 | 0 | 0 | 0 | 0 | 4 |
| +—+ | n | 2 (0, 4) | 1 (0, 3) | 1 (0, 3) | 1 (0, 3) | 1 (0, 3) | 1 (0, 3) |
| +—+ | n_unique | 1 (0, 4) | 1 (0, 3) | 1 (0, 3) | 1 (0, 3) | 1 (0, 3) | 1 (0, 3) |
| +—+ | post_p | NA (NA, NA) | 0.5 (0.38, 0.68) | 0.45 (0.33, 0.63) | 0.45 (0.35, 0.61) | 0.44 (0.32, 0.61) | 0.64 (0.47, 0.82) |
| +—+ | rate | 0.182 (0.047, 0.707) | 0.158 (0, 0.732) | 0.237 (0.081, 0.886) | 0.201 (0.063, 0.716) | 0.284 (0.088, 1.119) | 0.041 (0, 0.224) |
| +–+- | graduation | 0 | 20 | 93 | 2 | 0 | 13 |
| +–+- | futility | 0 | 46 | 0 | 34 | 79 | 2 |
| +–+- | max_n | 0 | 0 | 1 | 0 | 0 | 0 |
| +–+- | n | 8 (4, 13) | 3 (1, 7) | 6 (2, 11) | 3 (1, 6) | 3 (1, 5) | 3 (1, 5) |
| +–+- | n_unique | 7 (4, 11) | 3 (1, 6) | 6 (2, 10) | 3 (1, 5) | 2 (1, 4) | 2 (1, 5) |
| +–+- | post_p | NA (NA, NA) | 0.38 (0.22, 0.62) | 0.86 (0.52, 0.98) | 0.36 (0.2, 0.57) | 0.3 (0.17, 0.44) | 0.34 (0.19, 0.53) |
| +–+- | rate | 0.086 (0.04, 0.161) | 0.159 (0.075, 0.407) | 0.038 (0.015, 0.097) | 0.182 (0.085, 0.634) | 0.263 (0.134, 0.733) | 0.214 (0.105, 0.585) |
| +–++ | graduation | 0 | 20 | 93 | 2 | 0 | 316 |
| +–++ | futility | 0 | 55 | 3 | 98 | 150 | 2 |
| +–++ | max_n | 0 | 0 | 1 | 0 | 0 | 4 |
| +–++ | n | 4 (1, 7) | 2 (0, 5) | 2 (1, 6) | 2 (0, 4) | 2 (0, 4) | 1 (0, 4) |
| +–++ | n_unique | 3 (1, 6) | 2 (0, 4) | 2 (0, 5) | 2 (0, 4) | 2 (0, 3) | 1 (0, 4) |
| +–++ | post_p | NA (NA, NA) | 0.43 (0.29, 0.63) | 0.61 (0.38, 0.83) | 0.42 (0.26, 0.58) | 0.37 (0.24, 0.49) | 0.64 (0.42, 0.85) |
| +–++ | rate | 0.102 (0.035, 0.247) | 0.151 (0.067, 0.585) | 0.059 (0, 0.242) | 0.188 (0.07, 0.701) | 0.27 (0.099, 1.229) | 0.046 (0, 0.18) |
| +-+– | graduation | 0 | 21 | 29 | 2 | 0 | 46 |
| +-+– | futility | 0 | 122 | 0 | 87 | 130 | 0 |
| +-+– | max_n | 0 | 0 | 0 | 0 | 0 | 1 |
| +-+– | n | 1 (0, 3) | 1 (0, 2) | 1 (0, 3) | 1 (0, 2) | 1 (0, 2) | 1 (0, 2) |
| +-+– | n_unique | 1 (0, 3) | 1 (0, 2) | 1 (0, 3) | 1 (0, 2) | 1 (0, 2) | 1 (0, 2) |
| +-+– | post_p | NA (NA, NA) | 0.5 (0.37, 0.66) | 0.47 (0.35, 0.63) | 0.48 (0.38, 0.65) | 0.45 (0.34, 0.62) | 0.48 (0.38, 0.65) |
| +-+– | rate | 0.161 (0.039, 0.746) | 0.164 (0, 0.841) | 0.207 (0.061, 1.002) | 0.198 (0.047, 0.674) | 0.262 (0.051, 1.355) | 0.215 (0.041, 1.125) |
| +-+-+ | graduation | 0 | 21 | 31 | 2 | 0 | 325 |
| +-+-+ | futility | 0 | 128 | 3 | 126 | 173 | 0 |
| +-+-+ | max_n | 0 | 0 | 0 | 0 | 0 | 5 |
| +-+-+ | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +-+-+ | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +-+-+ | post_p | NA (NA, NA) | 0.55 (0.55, 0.55) | 0.45 (0.45, 0.45) | 0.49 (0.46, 0.5) | 0.5 (0.5, 0.5) | NA (NA, NA) |
| +-+-+ | rate | 0.133 (0, 1.503) | 0.143 (0, 0.615) | 0.203 (0, 0.853) | 0.217 (0.097, 0.775) | 0.182 (0.028, 1.645) | 0 (0, 0.113) |
| +-++- | graduation | 0 | 21 | 111 | 2 | 0 | 46 |
| +-++- | futility | 0 | 153 | 0 | 109 | 179 | 2 |
| +-++- | max_n | 0 | 0 | 1 | 0 | 0 | 1 |
| +-++- | n | 25 (19, 33) | 6 (2, 14) | 22 (7, 31) | 5 (3, 12) | 4 (2, 7) | 5 (2, 9) |
| +-++- | n_unique | 23 (16, 30) | 5 (2, 12) | 19 (7, 29) | 5 (2, 11) | 4 (2, 7) | 4 (2, 8) |
| +-++- | post_p | NA (NA, NA) | 0.24 (0.09, 0.52) | 0.98 (0.84, 1) | 0.21 (0.1, 0.43) | 0.18 (0.08, 0.36) | 0.2 (0.08, 0.4) |
| +-++- | rate | 0.084 (0.06, 0.111) | 0.162 (0.095, 0.361) | 0.039 (0.024, 0.063) | 0.185 (0.109, 0.419) | 0.252 (0.148, 0.605) | 0.207 (0.121, 0.504) |
| +-+++ | graduation | 0 | 21 | 110 | 2 | 0 | 325 |
| +-+++ | futility | 0 | 158 | 3 | 144 | 209 | 2 |
| +-+++ | max_n | 0 | 0 | 1 | 0 | 0 | 5 |
| +-+++ | n | 18 (12, 25) | 5 (2, 12) | 12 (3, 21) | 4 (2, 10) | 4 (2, 7) | 7 (2, 19) |
| +-+++ | n_unique | 16 (11, 23) | 4 (1, 11) | 11 (3, 20) | 4 (2, 9) | 3 (2, 6) | 6 (2, 18) |
| +-+++ | post_p | NA (NA, NA) | 0.32 (0.14, 0.6) | 0.8 (0.45, 0.98) | 0.24 (0.1, 0.46) | 0.2 (0.09, 0.36) | 0.92 (0.62, 1) |
| +-+++ | rate | 0.095 (0.067, 0.135) | 0.154 (0.083, 0.377) | 0.059 (0.033, 0.11) | 0.192 (0.11, 0.46) | 0.246 (0.143, 0.557) | 0.039 (0.018, 0.078) |
| ++— | graduation | 0 | 22 | 2 | 230 | 197 | 12 |
| ++— | futility | 0 | 2 | 19 | 0 | 4 | 10 |
| ++— | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| ++— | n | 9 (5, 13) | 3 (1, 6) | 3 (1, 5) | 5 (2, 10) | 5 (2, 11) | 3 (1, 5) |
| ++— | n_unique | 7 (4, 12) | 3 (1, 6) | 2 (1, 5) | 5 (2, 10) | 5 (2, 10) | 3 (1, 5) |
| ++— | post_p | NA (NA, NA) | 0.39 (0.22, 0.66) | 0.34 (0.17, 0.55) | 0.85 (0.54, 0.98) | 0.86 (0.56, 0.98) | 0.34 (0.19, 0.52) |
| ++— | rate | 0.149 (0.094, 0.255) | 0.161 (0.069, 0.483) | 0.214 (0.098, 0.799) | 0.039 (0.013, 0.098) | 0.038 (0.015, 0.093) | 0.217 (0.102, 0.575) |
| ++–+ | graduation | 0 | 22 | 7 | 214 | 185 | 311 |
| ++–+ | futility | 0 | 15 | 22 | 63 | 95 | 10 |
| ++–+ | max_n | 0 | 0 | 0 | 0 | 0 | 4 |
| ++–+ | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| ++–+ | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| ++–+ | post_p | NA (NA, NA) | 0.48 (0.48, 0.48) | 0.48 (0.46, 0.5) | 0.6 (0.6, 0.6) | NA (NA, NA) | 0.44 (0.44, 0.44) |
| ++–+ | rate | 0.163 (0, 0.5) | 0.163 (0, 0.796) | 0.209 (0, 1.474) | 0.165 (0.004, 0.252) | 0.051 (0, 0.172) | 0 (0, 0.212) |
| ++-+- | graduation | 0 | 22 | 93 | 229 | 191 | 13 |
| ++-+- | futility | 0 | 47 | 19 | 28 | 74 | 12 |
| ++-+- | max_n | 0 | 0 | 1 | 0 | 0 | 0 |
| ++-+- | n | 1 (0, 2) | 0 (0, 2) | 0 (0, 2) | 0 (0, 2) | 0 (0, 2) | 0 (0, 2) |
| ++-+- | n_unique | 1 (0, 2) | 0 (0, 2) | 0 (0, 2) | 0 (0, 2) | 0 (0, 2) | 0 (0, 2) |
| ++-+- | post_p | NA (NA, NA) | 0.47 (0.39, 0.58) | 0.54 (0.43, 0.61) | 0.55 (0.44, 0.65) | 0.54 (0.43, 0.65) | 0.45 (0.37, 0.55) |
| ++-+- | rate | 0.113 (0, 0.488) | 0.207 (0, 1.228) | 0.061 (0, 0.353) | 0.026 (0, 0.238) | 0.05 (0, 0.244) | 0.24 (0, 2.116) |
| ++-++ | graduation | 0 | 22 | 93 | 213 | 181 | 311 |
| ++-++ | futility | 0 | 56 | 22 | 81 | 134 | 12 |
| ++-++ | max_n | 0 | 0 | 1 | 0 | 0 | 4 |
| ++-++ | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| ++-++ | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| ++-++ | post_p | NA (NA, NA) | 0.48 (0.45, 0.53) | NA (NA, NA) | 0.52 (0.52, 0.52) | 0.54 (0.54, 0.54) | 0.53 (0.53, 0.53) |
| ++-++ | rate | 0.19 (0.036, 1.21) | 0.191 (0, 1.469) | 0.094 (0, 0.951) | 0.068 (0, 0.675) | 0 (0, 0.083) | 0 (0, 0.663) |
| +++– | graduation | 0 | 23 | 29 | 213 | 177 | 44 |
| +++– | futility | 0 | 124 | 19 | 71 | 108 | 10 |
| +++– | max_n | 0 | 0 | 0 | 0 | 0 | 1 |
| +++– | n | 0 (0, 1) | 0 (0, 1) | 0 (0, 1) | 0 (0, 1) | 0 (0, 1) | 0 (0, 1) |
| +++– | n_unique | 0 (0, 1) | 0 (0, 1) | 0 (0, 1) | 0 (0, 1) | 0 (0, 1) | 0 (0, 1) |
| +++– | post_p | NA (NA, NA) | 0.49 (0.45, 0.57) | 0.51 (0.41, 0.56) | 0.55 (0.49, 0.6) | 0.53 (0.48, 0.58) | 0.48 (0.44, 0.56) |
| +++– | rate | 0.23 (0, 2.174) | 0.2 (0, 0.941) | 0.24 (0, 1.065) | 0.017 (0, 0.31) | 0.035 (0, 0.214) | 0.192 (0, 0.862) |
| +++-+ | graduation | 0 | 23 | 31 | 203 | 171 | 319 |
| +++-+ | futility | 0 | 130 | 22 | 104 | 145 | 10 |
| +++-+ | max_n | 0 | 0 | 0 | 0 | 0 | 5 |
| +++-+ | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +++-+ | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +++-+ | post_p | NA (NA, NA) | 0.5 (0.46, 0.5) | 0.52 (0.43, 0.56) | 0.46 (0.44, 0.57) | 0.42 (0.42, 0.42) | 0.58 (0.58, 0.58) |
| +++-+ | rate | 0.134 (0, 0.307) | 0.16 (0, 0.429) | 0.143 (0, 0.569) | 0.065 (0, 0.387) | 0.069 (0, 0.542) | 0 (0, 0.134) |
| ++++- | graduation | 0 | 23 | 111 | 212 | 172 | 44 |
| ++++- | futility | 0 | 154 | 19 | 90 | 153 | 12 |
| ++++- | max_n | 0 | 0 | 1 | 0 | 0 | 1 |
| ++++- | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| ++++- | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| ++++- | post_p | NA (NA, NA) | NA (NA, NA) | 0.48 (0.48, 0.48) | 0.51 (0.49, 0.52) | NA (NA, NA) | NA (NA, NA) |
| ++++- | rate | 0.124 (0, 1.351) | 0.138 (0, 0.923) | 0.112 (0, 1.572) | 0.074 (0, 0.438) | 0 (0, 0.204) | 0.118 (0, 1.589) |
| +++++ | graduation | 0 | 23 | 110 | 202 | 167 | 319 |
| +++++ | futility | 0 | 159 | 22 | 119 | 178 | 12 |
| +++++ | max_n | 0 | 0 | 1 | 0 | 0 | 5 |
| +++++ | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +++++ | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +++++ | post_p | NA (NA, NA) | 0.44 (0.39, 0.48) | NA (NA, NA) | 0.45 (0.42, 0.58) | 0.49 (0.44, 0.56) | 0.53 (0.47, 0.59) |
| +++++ | rate | 0.109 (0, 0.448) | 0.283 (0.078, 1.443) | 0.142 (0, 0.973) | 0.081 (0, 0.416) | 0 (0, 0.16) | 0.079 (0, 0.192) |
Posterior probabilities
Randomization probabilities
PFS rates
Posterior probabilities
Randomization probabilities