Setting description

Several treatments more effective in distinctive signatures: (TC1, AR- & TP53-); (TC2, TEfus+); (TC3 and TC4, HRD+); (TC5,PI3K )

Simulations setting

Survival curves (by signature)


PFS distributions (by signature)


Treatment effects (by signature)

signature var Other TC1 TC2 TC3 TC4 TC5
all param scale = 0.112, shape = 1.05 scale = 0.086, shape = 1.05 scale = 0.132, shape = 1.05 scale = 0.133, shape = 1.05 scale = 0.178, shape = 1.05 scale = 0.128, shape = 1.05
all summary mean = 8.8, median = 6.3 mean = 11.4, median = 8.2 mean = 7.4, median = 5.3 mean = 7.4, median = 5.3 mean = 5.5, median = 4 mean = 7.7, median = 5.5
all effect af = 1, hr = 1 af = 1.29, hr = 0.76 af = 0.84, hr = 1.19 af = 0.84, hr = 1.21 af = 0.63, hr = 1.63 af = 0.88, hr = 1.15
AR- & TP53- param scale = 0.112, shape = 1.05 scale = 0.05, shape = 1.05 scale = 0.159, shape = 1.05 scale = 0.132, shape = 1.05 scale = 0.18, shape = 1.05 scale = 0.149, shape = 1.05
AR- & TP53- summary mean = 8.8, median = 6.3 mean = 19.8, median = 14.2 mean = 6.2, median = 4.4 mean = 7.4, median = 5.3 mean = 5.5, median = 3.9 mean = 6.6, median = 4.7
AR- & TP53- effect af = 1, hr = 1 af = 2.25, hr = 0.43 af = 0.7, hr = 1.45 af = 0.84, hr = 1.2 af = 0.62, hr = 1.65 af = 0.75, hr = 1.35
HRD+ param scale = 0.112, shape = 1.05 scale = 0.086, shape = 1.05 scale = 0.135, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.153, shape = 1.05
HRD+ summary mean = 8.8, median = 6.3 mean = 11.4, median = 8.2 mean = 7.2, median = 5.2 mean = 25, median = 18 mean = 25, median = 18 mean = 6.4, median = 4.6
HRD+ effect af = 1, hr = 1 af = 1.3, hr = 0.76 af = 0.82, hr = 1.23 af = 2.85, hr = 0.33 af = 2.85, hr = 0.33 af = 0.73, hr = 1.39
TP53+ param scale = 0.112, shape = 1.05 scale = 0.133, shape = 1.05 scale = 0.095, shape = 1.05 scale = 0.14, shape = 1.05 scale = 0.184, shape = 1.05 scale = 0.09, shape = 1.05
TP53+ summary mean = 8.8, median = 6.3 mean = 7.4, median = 5.3 mean = 10.4, median = 7.5 mean = 7, median = 5 mean = 5.3, median = 3.8 mean = 10.9, median = 7.8
TP53+ effect af = 1, hr = 1 af = 0.84, hr = 1.2 af = 1.18, hr = 0.84 af = 0.79, hr = 1.27 af = 0.61, hr = 1.69 af = 1.24, hr = 0.8
TEfus+ param scale = 0.112, shape = 1.05 scale = 0.116, shape = 1.05 scale = 0.049, shape = 1.05 scale = 0.135, shape = 1.05 scale = 0.183, shape = 1.05 scale = 0.107, shape = 1.05
TEfus+ summary mean = 8.8, median = 6.3 mean = 8.4, median = 6.1 mean = 19.9, median = 14.3 mean = 7.3, median = 5.2 mean = 5.4, median = 3.9 mean = 9.1, median = 6.6
TEfus+ effect af = 1, hr = 1 af = 0.96, hr = 1.04 af = 2.27, hr = 0.42 af = 0.83, hr = 1.22 af = 0.61, hr = 1.68 af = 1.04, hr = 0.96
PI3K+ param scale = 0.112, shape = 1.05 scale = 0.107, shape = 1.05 scale = 0.117, shape = 1.05 scale = 0.145, shape = 1.05 scale = 0.198, shape = 1.05 scale = 0.038, shape = 1.05
PI3K+ summary mean = 8.8, median = 6.3 mean = 9.2, median = 6.6 mean = 8.4, median = 6 mean = 6.8, median = 4.9 mean = 5, median = 3.6 mean = 26.1, median = 18.8
PI3K+ effect af = 1, hr = 1 af = 1.04, hr = 0.96 af = 0.96, hr = 1.05 af = 0.77, hr = 1.31 af = 0.56, hr = 1.83 af = 2.97, hr = 0.32



Survival curves (by subgroup)


PFS distributions (by subgroup)


Treatment effects (by subgroup)

subtype var Other TC1 TC2 TC3 TC4 TC5
—– param scale = 0.112, shape = 1.05 scale = 0.042, shape = 1.05 scale = 0.182, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.182, shape = 1.05
—– summary mean = 8.8, median = 6.3 mean = 23.4, median = 16.9 mean = 5.4, median = 3.9 mean = 6.3, median = 4.5 mean = 4.5, median = 3.3 mean = 5.4, median = 3.9
—– effect af = 1, hr = 1 af = 2.67, hr = 0.36 af = 0.61, hr = 1.67 af = 0.71, hr = 1.43 af = 0.52, hr = 2 af = 0.61, hr = 1.67
—-+ param scale = 0.112, shape = 1.05 scale = 0.05, shape = 1.05 scale = 0.182, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.037, shape = 1.05
—-+ summary mean = 8.8, median = 6.3 mean = 19.4, median = 14 mean = 5.4, median = 3.9 mean = 6.3, median = 4.5 mean = 4.5, median = 3.3 mean = 26.6, median = 19.1
—-+ effect af = 1, hr = 1 af = 2.21, hr = 0.43 af = 0.61, hr = 1.67 af = 0.71, hr = 1.43 af = 0.52, hr = 2 af = 3.03, hr = 0.31
—+- param scale = 0.112, shape = 1.05 scale = 0.058, shape = 1.05 scale = 0.042, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.182, shape = 1.05
—+- summary mean = 8.8, median = 6.3 mean = 17, median = 12.2 mean = 23.4, median = 16.9 mean = 6.3, median = 4.5 mean = 4.5, median = 3.3 mean = 5.4, median = 3.9
—+- effect af = 1, hr = 1 af = 1.94, hr = 0.5 af = 2.67, hr = 0.36 af = 0.71, hr = 1.43 af = 0.52, hr = 2 af = 0.61, hr = 1.67
—++ param scale = 0.112, shape = 1.05 scale = 0.064, shape = 1.05 scale = 0.05, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.037, shape = 1.05
—++ summary mean = 8.8, median = 6.3 mean = 15.4, median = 11.1 mean = 19.4, median = 14 mean = 6.3, median = 4.5 mean = 4.5, median = 3.3 mean = 26.6, median = 19.1
—++ effect af = 1, hr = 1 af = 1.75, hr = 0.56 af = 2.21, hr = 0.43 af = 0.71, hr = 1.43 af = 0.52, hr = 2 af = 3.03, hr = 0.31
–+– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
–+– summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
–+– effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–+-+ param scale = 0.112, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.182, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.037, shape = 1.05
–+-+ summary mean = 8.8, median = 6.3 mean = 7.1, median = 5.1 mean = 5.4, median = 3.9 mean = 6.3, median = 4.5 mean = 4.5, median = 3.3 mean = 26.6, median = 19.1
–+-+ effect af = 1, hr = 1 af = 0.81, hr = 1.25 af = 0.61, hr = 1.67 af = 0.71, hr = 1.43 af = 0.52, hr = 2 af = 3.03, hr = 0.31
–++- param scale = 0.112, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.182, shape = 1.05
–++- summary mean = 8.8, median = 6.3 mean = 7.1, median = 5.1 mean = 25, median = 18 mean = 6.3, median = 4.5 mean = 4.5, median = 3.3 mean = 5.4, median = 3.9
–++- effect af = 1, hr = 1 af = 0.81, hr = 1.25 af = 2.85, hr = 0.33 af = 0.71, hr = 1.43 af = 0.52, hr = 2 af = 0.61, hr = 1.67
–+++ param scale = 0.112, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.05, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.037, shape = 1.05
–+++ summary mean = 8.8, median = 6.3 mean = 7.1, median = 5.1 mean = 19.4, median = 14 mean = 6.3, median = 4.5 mean = 4.5, median = 3.3 mean = 26.6, median = 19.1
–+++ effect af = 1, hr = 1 af = 0.81, hr = 1.25 af = 2.21, hr = 0.43 af = 0.71, hr = 1.43 af = 0.52, hr = 2 af = 3.03, hr = 0.31
-+— param scale = 0.112, shape = 1.05 scale = 0.058, shape = 1.05 scale = 0.182, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.182, shape = 1.05
-+— summary mean = 8.8, median = 6.3 mean = 17, median = 12.2 mean = 5.4, median = 3.9 mean = 25, median = 18 mean = 25, median = 18 mean = 5.4, median = 3.9
-+— effect af = 1, hr = 1 af = 1.94, hr = 0.5 af = 0.61, hr = 1.67 af = 2.85, hr = 0.33 af = 2.85, hr = 0.33 af = 0.61, hr = 1.67
-+–+ param scale = 0.112, shape = 1.05 scale = 0.058, shape = 1.05 scale = 0.182, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.039, shape = 1.05
-+–+ summary mean = 8.8, median = 6.3 mean = 17, median = 12.2 mean = 5.4, median = 3.9 mean = 25, median = 18 mean = 25, median = 18 mean = 25, median = 18
-+–+ effect af = 1, hr = 1 af = 1.94, hr = 0.5 af = 0.61, hr = 1.67 af = 2.85, hr = 0.33 af = 2.85, hr = 0.33 af = 2.85, hr = 0.33
-+-+- param scale = 0.112, shape = 1.05 scale = 0.071, shape = 1.05 scale = 0.058, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.182, shape = 1.05
-+-+- summary mean = 8.8, median = 6.3 mean = 13.8, median = 9.9 mean = 17, median = 12.2 mean = 25, median = 18 mean = 25, median = 18 mean = 5.4, median = 3.9
-+-+- effect af = 1, hr = 1 af = 1.56, hr = 0.62 af = 1.94, hr = 0.5 af = 2.85, hr = 0.33 af = 2.85, hr = 0.33 af = 0.61, hr = 1.67
-+-++ param scale = 0.112, shape = 1.05 scale = 0.071, shape = 1.05 scale = 0.058, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.039, shape = 1.05
-+-++ summary mean = 8.8, median = 6.3 mean = 13.8, median = 9.9 mean = 17, median = 12.2 mean = 25, median = 18 mean = 25, median = 18 mean = 25, median = 18
-+-++ effect af = 1, hr = 1 af = 1.56, hr = 0.62 af = 1.94, hr = 0.5 af = 2.85, hr = 0.33 af = 2.85, hr = 0.33 af = 2.85, hr = 0.33
-++– param scale = 0.112, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.182, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.182, shape = 1.05
-++– summary mean = 8.8, median = 6.3 mean = 7.1, median = 5.1 mean = 5.4, median = 3.9 mean = 25, median = 18 mean = 25, median = 18 mean = 5.4, median = 3.9
-++– effect af = 1, hr = 1 af = 0.81, hr = 1.25 af = 0.61, hr = 1.67 af = 2.85, hr = 0.33 af = 2.85, hr = 0.33 af = 0.61, hr = 1.67
-++-+ param scale = 0.112, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.182, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.039, shape = 1.05
-++-+ summary mean = 8.8, median = 6.3 mean = 7.1, median = 5.1 mean = 5.4, median = 3.9 mean = 25, median = 18 mean = 25, median = 18 mean = 25, median = 18
-++-+ effect af = 1, hr = 1 af = 0.81, hr = 1.25 af = 0.61, hr = 1.67 af = 2.85, hr = 0.33 af = 2.85, hr = 0.33 af = 2.85, hr = 0.33
-+++- param scale = 0.112, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.058, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.182, shape = 1.05
-+++- summary mean = 8.8, median = 6.3 mean = 7.1, median = 5.1 mean = 17, median = 12.2 mean = 25, median = 18 mean = 25, median = 18 mean = 5.4, median = 3.9
-+++- effect af = 1, hr = 1 af = 0.81, hr = 1.25 af = 1.94, hr = 0.5 af = 2.85, hr = 0.33 af = 2.85, hr = 0.33 af = 0.61, hr = 1.67
-++++ param scale = 0.112, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.058, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.039, shape = 1.05
-++++ summary mean = 8.8, median = 6.3 mean = 7.1, median = 5.1 mean = 17, median = 12.2 mean = 25, median = 18 mean = 25, median = 18 mean = 25, median = 18
-++++ effect af = 1, hr = 1 af = 0.81, hr = 1.25 af = 1.94, hr = 0.5 af = 2.85, hr = 0.33 af = 2.85, hr = 0.33 af = 2.85, hr = 0.33
+—- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+—- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+—- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+—+ param scale = 0.112, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.182, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.039, shape = 1.05
+—+ summary mean = 8.8, median = 6.3 mean = 7.1, median = 5.1 mean = 5.4, median = 3.9 mean = 6.3, median = 4.5 mean = 4.5, median = 3.3 mean = 25, median = 18
+—+ effect af = 1, hr = 1 af = 0.81, hr = 1.25 af = 0.61, hr = 1.67 af = 0.71, hr = 1.43 af = 0.52, hr = 2 af = 2.85, hr = 0.33
+–+- param scale = 0.112, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.182, shape = 1.05
+–+- summary mean = 8.8, median = 6.3 mean = 7.1, median = 5.1 mean = 25, median = 18 mean = 6.3, median = 4.5 mean = 4.5, median = 3.3 mean = 5.4, median = 3.9
+–+- effect af = 1, hr = 1 af = 0.81, hr = 1.25 af = 2.85, hr = 0.33 af = 0.71, hr = 1.43 af = 0.52, hr = 2 af = 0.61, hr = 1.67
+–++ param scale = 0.112, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.058, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.039, shape = 1.05
+–++ summary mean = 8.8, median = 6.3 mean = 7.1, median = 5.1 mean = 17, median = 12.2 mean = 6.3, median = 4.5 mean = 4.5, median = 3.3 mean = 25, median = 18
+–++ effect af = 1, hr = 1 af = 0.81, hr = 1.25 af = 1.94, hr = 0.5 af = 0.71, hr = 1.43 af = 0.52, hr = 2 af = 2.85, hr = 0.33
+-+– param scale = 0.112, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.182, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.182, shape = 1.05
+-+– summary mean = 8.8, median = 6.3 mean = 7.1, median = 5.1 mean = 5.4, median = 3.9 mean = 6.3, median = 4.5 mean = 4.5, median = 3.3 mean = 5.4, median = 3.9
+-+– effect af = 1, hr = 1 af = 0.81, hr = 1.25 af = 0.61, hr = 1.67 af = 0.71, hr = 1.43 af = 0.52, hr = 2 af = 0.61, hr = 1.67
+-+-+ param scale = 0.112, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.182, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.039, shape = 1.05
+-+-+ summary mean = 8.8, median = 6.3 mean = 7.1, median = 5.1 mean = 5.4, median = 3.9 mean = 6.3, median = 4.5 mean = 4.5, median = 3.3 mean = 25, median = 18
+-+-+ effect af = 1, hr = 1 af = 0.81, hr = 1.25 af = 0.61, hr = 1.67 af = 0.71, hr = 1.43 af = 0.52, hr = 2 af = 2.85, hr = 0.33
+-++- param scale = 0.112, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.182, shape = 1.05
+-++- summary mean = 8.8, median = 6.3 mean = 7.1, median = 5.1 mean = 25, median = 18 mean = 6.3, median = 4.5 mean = 4.5, median = 3.3 mean = 5.4, median = 3.9
+-++- effect af = 1, hr = 1 af = 0.81, hr = 1.25 af = 2.85, hr = 0.33 af = 0.71, hr = 1.43 af = 0.52, hr = 2 af = 0.61, hr = 1.67
+-+++ param scale = 0.112, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.058, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.039, shape = 1.05
+-+++ summary mean = 8.8, median = 6.3 mean = 7.1, median = 5.1 mean = 17, median = 12.2 mean = 6.3, median = 4.5 mean = 4.5, median = 3.3 mean = 25, median = 18
+-+++ effect af = 1, hr = 1 af = 0.81, hr = 1.25 af = 1.94, hr = 0.5 af = 0.71, hr = 1.43 af = 0.52, hr = 2 af = 2.85, hr = 0.33
++— param scale = 0.112, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.182, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.182, shape = 1.05
++— summary mean = 8.8, median = 6.3 mean = 7.1, median = 5.1 mean = 5.4, median = 3.9 mean = 25, median = 18 mean = 25, median = 18 mean = 5.4, median = 3.9
++— effect af = 1, hr = 1 af = 0.81, hr = 1.25 af = 0.61, hr = 1.67 af = 2.85, hr = 0.33 af = 2.85, hr = 0.33 af = 0.61, hr = 1.67
++–+ param scale = 0.112, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.182, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.039, shape = 1.05
++–+ summary mean = 8.8, median = 6.3 mean = 7.1, median = 5.1 mean = 5.4, median = 3.9 mean = 25, median = 18 mean = 25, median = 18 mean = 25, median = 18
++–+ effect af = 1, hr = 1 af = 0.81, hr = 1.25 af = 0.61, hr = 1.67 af = 2.85, hr = 0.33 af = 2.85, hr = 0.33 af = 2.85, hr = 0.33
++-+- param scale = 0.112, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.058, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.182, shape = 1.05
++-+- summary mean = 8.8, median = 6.3 mean = 7.1, median = 5.1 mean = 17, median = 12.2 mean = 25, median = 18 mean = 25, median = 18 mean = 5.4, median = 3.9
++-+- effect af = 1, hr = 1 af = 0.81, hr = 1.25 af = 1.94, hr = 0.5 af = 2.85, hr = 0.33 af = 2.85, hr = 0.33 af = 0.61, hr = 1.67
++-++ param scale = 0.112, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.058, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.039, shape = 1.05
++-++ summary mean = 8.8, median = 6.3 mean = 7.1, median = 5.1 mean = 17, median = 12.2 mean = 25, median = 18 mean = 25, median = 18 mean = 25, median = 18
++-++ effect af = 1, hr = 1 af = 0.81, hr = 1.25 af = 1.94, hr = 0.5 af = 2.85, hr = 0.33 af = 2.85, hr = 0.33 af = 2.85, hr = 0.33
+++– param scale = 0.112, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.182, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.182, shape = 1.05
+++– summary mean = 8.8, median = 6.3 mean = 7.1, median = 5.1 mean = 5.4, median = 3.9 mean = 25, median = 18 mean = 25, median = 18 mean = 5.4, median = 3.9
+++– effect af = 1, hr = 1 af = 0.81, hr = 1.25 af = 0.61, hr = 1.67 af = 2.85, hr = 0.33 af = 2.85, hr = 0.33 af = 0.61, hr = 1.67
+++-+ param scale = 0.112, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.182, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.039, shape = 1.05
+++-+ summary mean = 8.8, median = 6.3 mean = 7.1, median = 5.1 mean = 5.4, median = 3.9 mean = 25, median = 18 mean = 25, median = 18 mean = 25, median = 18
+++-+ effect af = 1, hr = 1 af = 0.81, hr = 1.25 af = 0.61, hr = 1.67 af = 2.85, hr = 0.33 af = 2.85, hr = 0.33 af = 2.85, hr = 0.33
++++- param scale = 0.112, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.064, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.182, shape = 1.05
++++- summary mean = 8.8, median = 6.3 mean = 7.1, median = 5.1 mean = 15.4, median = 11.1 mean = 25, median = 18 mean = 25, median = 18 mean = 5.4, median = 3.9
++++- effect af = 1, hr = 1 af = 0.81, hr = 1.25 af = 1.75, hr = 0.56 af = 2.85, hr = 0.33 af = 2.85, hr = 0.33 af = 0.61, hr = 1.67
+++++ param scale = 0.112, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.064, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.039, shape = 1.05
+++++ summary mean = 8.8, median = 6.3 mean = 7.1, median = 5.1 mean = 15.4, median = 11.1 mean = 25, median = 18 mean = 25, median = 18 mean = 25, median = 18
+++++ effect af = 1, hr = 1 af = 0.81, hr = 1.25 af = 1.75, hr = 0.56 af = 2.85, hr = 0.33 af = 2.85, hr = 0.33 af = 2.85, hr = 0.33

Errors and power


graduation (counts and proportions):
TC1 TC2 TC3 TC4 TC5
all 20 2 2 0 12
AR- & TP53- 241 0 3 1 1
HRD+ 2 0 228 197 0
TP53+ 1 27 0 0 35
TEfus+ 0 91 0 0 1
PI3K+ 0 5 0 0 307
TC1 TC2 TC3 TC4 TC5
all 0.040 0.004 0.004 0.000 0.024
AR- & TP53- 0.482 0.000 0.006 0.002 0.002
HRD+ 0.004 0.000 0.456 0.394 0.000
TP53+ 0.002 0.054 0.000 0.000 0.070
TEfus+ 0.000 0.182 0.000 0.000 0.002
PI3K+ 0.000 0.010 0.000 0.000 0.614
futility (counts and proportions):
TC1 TC2 TC3 TC4 TC5
all 0 0 0 4 0
AR- & TP53- 1 60 19 34 3
HRD+ 2 19 0 0 10
TP53+ 122 0 87 126 0
TEfus+ 46 0 34 75 2
PI3K+ 13 3 75 104 0
TC1 TC2 TC3 TC4 TC5
all 0.000 0.000 0.000 0.008 0.000
AR- & TP53- 0.002 0.120 0.038 0.068 0.006
HRD+ 0.004 0.038 0.000 0.000 0.020
TP53+ 0.244 0.000 0.174 0.252 0.000
TEfus+ 0.092 0.000 0.068 0.150 0.004
PI3K+ 0.026 0.006 0.150 0.208 0.000
max sample size (counts and proportions):
TC1 TC2 TC3 TC4 TC5
all 0 0 0 0 0
AR- & TP53- 244 20 111 31 46
HRD+ 0 0 0 0 0
TP53+ 0 0 0 0 1
TEfus+ 0 1 0 0 0
PI3K+ 0 0 0 0 4
TC1 TC2 TC3 TC4 TC5
all 0.000 0.000 0.000 0.000 0.000
AR- & TP53- 0.488 0.040 0.222 0.062 0.092
HRD+ 0.000 0.000 0.000 0.000 0.000
TP53+ 0.000 0.000 0.000 0.000 0.002
TEfus+ 0.000 0.002 0.000 0.000 0.000
PI3K+ 0.000 0.000 0.000 0.000 0.008


Operating characteristics

char overall TC1 TC2 TC3 TC4 TC5
err_sign 0.1182365 0.0320641 0.0400802 0.0100200 0.0020040 0.0360721
err_type 0.2024048 0.0460922 0.0621242 0.0100200 0.0020040 0.0941884
pow_sign 0.9478958 0.4829659 0.1823647 0.4569138 0.3947896 0.6152305
pow_type 0.9619238 0.5110220 0.2224449 0.4669339 0.3967936 0.6513026

Median results at the end of the trial

By signature:
signature var Control TC1 TC2 TC3 TC4 TC5
all graduation 0 20 2 2 0 12
all futility 0 0 0 0 4 0
all max_n 0 0 0 0 0 0
all n 426 (399, 453) 188 (81, 236) 160 (103, 210) 151 (97, 219) 114 (86, 168) 141 (85, 217)
all n_unique 392 (369, 417) 176 (74, 221) 145 (93, 195) 138 (89, 204) 103 (77, 152) 128 (76, 201)
all time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
all time_stop NA (NA, NA) 5 (4, 8) 6 (4, 7) 6 (6, 7) 10 (8, 14) 6 (5, 10)
all post_p NA (NA, NA) 1 (0.57, 1) 0.88 (0.23, 1) 0.21 (0, 0.82) 0.21 (0, 0.78) 0.96 (0.25, 1)
all rate 0.092 (0.085, 0.1) 0.065 (0.054, 0.087) 0.079 (0.067, 0.097) 0.101 (0.083, 0.12) 0.1 (0.083, 0.127) 0.073 (0.056, 0.097)
AR- & TP53- graduation 0 241 0 3 1 1
AR- & TP53- futility 0 1 60 19 34 3
AR- & TP53- max_n 0 244 20 111 31 46
AR- & TP53- n 260 (240, 285) 150 (26, 155) 57 (32, 100) 87 (47, 153) 59 (36, 103) 69 (34, 143)
AR- & TP53- n_unique 242 (222, 264) 137 (25, 149) 51 (28, 92) 80 (42, 146) 53 (33, 96) 63 (31, 134)
AR- & TP53- time_trial 36 (36, 36) 36 (6, 36) 36 (25, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
AR- & TP53- time_stop NA (NA, NA) 7 (5, 15) 18 (12, 32) 14 (11, 25) 15 (10, 20) 13 (10, 18)
AR- & TP53- post_p NA (NA, NA) 1 (0.99, 1) 0.1 (0, 0.53) 0.34 (0, 0.92) 0.46 (0, 0.93) 0.5 (0.01, 0.97)
AR- & TP53- rate 0.085 (0.077, 0.094) 0.045 (0.036, 0.053) 0.112 (0.085, 0.149) 0.092 (0.065, 0.121) 0.085 (0.063, 0.131) 0.083 (0.06, 0.125)
HRD+ graduation 0 2 0 228 197 0
HRD+ futility 0 2 19 0 0 10
HRD+ max_n 0 0 0 0 0 0
HRD+ n 63 (52, 75) 16 (7, 28) 22 (14, 37) 37 (25, 54) 38 (25, 58) 18 (11, 28)
HRD+ n_unique 58 (46, 68) 14 (6, 25) 20 (12, 32) 34 (23, 50) 35 (22, 53) 16 (10, 25)
HRD+ time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (19, 36) 36 (20, 36) 36 (36, 36)
HRD+ time_stop NA (NA, NA) 31 (28, 33) 35 (26, 35) 24 (16, 32) 24 (17, 33) 32 (30, 35)
HRD+ post_p NA (NA, NA) 0.48 (0.11, 0.87) 0.31 (0.06, 0.8) 1 (0.98, 1) 1 (0.96, 1) 0.17 (0.02, 0.58)
HRD+ rate 0.097 (0.078, 0.118) 0.09 (0.061, 0.151) 0.101 (0.07, 0.156) 0.038 (0.028, 0.05) 0.038 (0.028, 0.052) 0.124 (0.082, 0.188)
TP53+ graduation 0 1 27 0 0 35
TP53+ futility 0 122 0 87 126 0
TP53+ max_n 0 0 0 0 0 1
TP53+ n 137 (121, 153) 50 (28, 77) 81 (40, 109) 45 (28, 66) 37 (25, 58) 55 (29, 96)
TP53+ n_unique 125 (109, 139) 45 (25, 69) 74 (37, 99) 40 (26, 60) 34 (23, 52) 50 (26, 87)
TP53+ time_trial 36 (36, 36) 36 (22, 36) 36 (36, 36) 36 (26, 36) 36 (21, 36) 36 (36, 36)
TP53+ time_stop NA (NA, NA) 24 (16, 32) 15 (11, 26) 24 (17, 33) 24 (16, 32) 14 (11, 23)
TP53+ post_p NA (NA, NA) 0.09 (0.01, 0.45) 1 (0.89, 1) 0.15 (0.02, 0.56) 0.07 (0, 0.42) 1 (0.88, 1)
TP53+ rate 0.103 (0.09, 0.12) 0.133 (0.107, 0.166) 0.064 (0.051, 0.08) 0.127 (0.102, 0.158) 0.142 (0.11, 0.189) 0.057 (0.044, 0.078)
TEfus+ graduation 0 0 91 0 0 1
TEfus+ futility 0 46 0 34 75 2
TEfus+ max_n 0 0 1 0 0 0
TEfus+ n 129 (113, 146) 39 (25, 59) 94 (31, 118) 45 (32, 63) 39 (27, 54) 47 (28, 81)
TEfus+ n_unique 117 (102, 132) 35 (22, 53) 86 (29, 107) 40 (29, 59) 35 (25, 49) 43 (25, 74)
TEfus+ time_trial 36 (36, 36) 36 (36, 36) 36 (15, 36) 36 (36, 36) 36 (26, 36) 36 (36, 36)
TEfus+ time_stop NA (NA, NA) 27 (18, 35) 15 (11, 27) 21 (15, 30) 22 (15, 31) 13 (12, 13)
TEfus+ post_p NA (NA, NA) 0.08 (0, 0.41) 1 (0.97, 1) 0.18 (0.02, 0.63) 0.08 (0, 0.47) 0.88 (0.36, 1)
TEfus+ rate 0.082 (0.071, 0.094) 0.111 (0.089, 0.145) 0.046 (0.037, 0.057) 0.1 (0.076, 0.129) 0.112 (0.085, 0.157) 0.063 (0.048, 0.086)
PI3K+ graduation 0 0 5 0 0 307
PI3K+ futility 0 13 3 75 104 0
PI3K+ max_n 0 0 0 0 0 4
PI3K+ n 138 (120, 155) 45 (25, 73) 63 (34, 96) 43 (27, 72) 34 (25, 53) 62 (27, 124)
PI3K+ n_unique 126 (109, 141) 41 (21, 66) 56 (32, 87) 39 (24, 66) 31 (22, 48) 56 (25, 115)
PI3K+ time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (26, 36) 36 (21, 36) 22 (11, 36)
PI3K+ time_stop NA (NA, NA) 23 (15, 33) 14 (12, 30) 23 (17, 31) 22 (16, 33) 15 (10, 28)
PI3K+ post_p NA (NA, NA) 0.47 (0.07, 0.9) 0.84 (0.36, 0.99) 0.11 (0.01, 0.53) 0.04 (0, 0.32) 1 (1, 1)
PI3K+ rate 0.097 (0.085, 0.112) 0.096 (0.074, 0.132) 0.079 (0.061, 0.102) 0.123 (0.096, 0.161) 0.144 (0.107, 0.194) 0.037 (0.029, 0.046)


By subgroup combinations:
subtype var Control TC1 TC2 TC3 TC4 TC5
—– graduation 0 254 2 5 1 13
—– futility 0 1 60 19 38 3
—– max_n 0 244 20 111 31 46
—– n 159 (140, 175) 94 (20, 120) 15 (8, 52) 37 (10, 110) 13 (7, 54) 19 (8, 92)
—– n_unique 149 (131, 165) 91 (20, 116) 14 (7, 51) 34 (9, 106) 11 (6, 52) 16 (7, 88)
—– post_p NA (NA, NA) 1 (0.99, 1) 0.02 (0, 0.07) 0.02 (0, 0.13) 0.01 (0, 0.06) 0.01 (0, 0.08)
—– rate 0.086 (0.076, 0.098) 0.041 (0.033, 0.051) 0.195 (0.152, 0.308) 0.165 (0.13, 0.239) 0.235 (0.18, 0.383) 0.196 (0.153, 0.295)
—-+ graduation 0 251 7 5 1 301
—-+ futility 0 6 61 74 133 3
—-+ max_n 0 242 20 108 29 44
—-+ n 35 (27, 43) 8 (1, 22) 7 (3, 21) 8 (3, 23) 6 (3, 16) 16 (6, 37)
—-+ n_unique 32 (25, 40) 7 (1, 20) 6 (3, 19) 7 (3, 22) 5 (2, 14) 15 (6, 35)
—-+ post_p NA (NA, NA) 0.87 (0.51, 0.99) 0.14 (0.03, 0.35) 0.18 (0.05, 0.43) 0.13 (0.03, 0.29) 0.99 (0.83, 1)
—-+ rate 0.092 (0.069, 0.126) 0.05 (0.024, 0.096) 0.198 (0.129, 0.402) 0.166 (0.11, 0.344) 0.246 (0.158, 0.498) 0.038 (0.024, 0.06)
—+- graduation 0 235 84 5 1 13
—+- futility 0 31 60 41 97 5
—+- max_n 0 233 21 111 31 46
—+- n 5 (2, 9) 1 (0, 4) 3 (1, 8) 2 (1, 5) 2 (0, 4) 2 (1, 5)
—+- n_unique 5 (2, 8) 1 (0, 4) 3 (0, 7) 2 (0, 4) 2 (0, 4) 2 (1, 5)
—+- post_p NA (NA, NA) 0.53 (0.36, 0.81) 0.68 (0.43, 0.87) 0.37 (0.21, 0.55) 0.34 (0.21, 0.47) 0.35 (0.19, 0.52)
—+- rate 0.063 (0.025, 0.132) 0.07 (0.02, 0.26) 0.045 (0, 0.137) 0.183 (0.081, 0.669) 0.255 (0.117, 0.821) 0.224 (0.085, 0.705)
—++ graduation 0 234 84 5 1 301
—++ futility 0 33 61 89 167 5
—++ max_n 0 232 21 108 29 44
—++ n 15 (10, 21) 3 (0, 9) 8 (2, 16) 4 (2, 9) 4 (2, 7) 6 (2, 15)
—++ n_unique 14 (9, 19) 3 (0, 8) 7 (2, 15) 4 (2, 9) 3 (1, 6) 5 (2, 14)
—++ post_p NA (NA, NA) 0.49 (0.26, 0.82) 0.68 (0.34, 0.93) 0.22 (0.09, 0.4) 0.19 (0.06, 0.35) 0.8 (0.46, 0.96)
—++ rate 0.067 (0.043, 0.103) 0.073 (0.028, 0.187) 0.052 (0.023, 0.123) 0.182 (0.102, 0.473) 0.248 (0.135, 0.6) 0.037 (0.016, 0.084)
–+– graduation 0 21 29 2 0 46
–+– futility 0 122 0 87 130 0
–+– max_n 0 0 0 0 0 1
–+– n 26 (19, 34) 11 (4, 23) 11 (4, 23) 9 (4, 20) 10 (4, 24) 10 (3, 22)
–+– n_unique 23 (17, 31) 10 (4, 21) 10 (4, 21) 9 (3, 19) 9 (3, 22) 8 (3, 20)
–+– post_p NA (NA, NA) 0.49 (0.18, 0.85) 0.46 (0.17, 0.82) 0.44 (0.16, 0.83) 0.48 (0.18, 0.85) 0.48 (0.18, 0.84)
–+– rate 0.114 (0.086, 0.151) 0.121 (0.08, 0.214) 0.123 (0.083, 0.272) 0.125 (0.082, 0.277) 0.123 (0.081, 0.243) 0.123 (0.077, 0.238)
–+-+ graduation 0 21 31 2 0 325
–+-+ futility 0 128 3 126 173 0
–+-+ max_n 0 0 0 0 0 5
–+-+ n 29 (21, 36) 9 (3, 25) 6 (3, 19) 7 (3, 21) 5 (3, 13) 13 (4, 31)
–+-+ n_unique 26 (19, 33) 8 (3, 23) 6 (3, 18) 6 (3, 20) 5 (2, 11) 12 (4, 29)
–+-+ post_p NA (NA, NA) 0.43 (0.16, 0.82) 0.26 (0.11, 0.57) 0.33 (0.12, 0.68) 0.23 (0.11, 0.45) 1 (0.95, 1)
–+-+ rate 0.144 (0.111, 0.19) 0.151 (0.099, 0.37) 0.201 (0.13, 0.432) 0.181 (0.117, 0.451) 0.241 (0.153, 0.538) 0.037 (0.022, 0.062)
–++- graduation 0 21 111 2 0 46
–++- futility 0 153 0 109 179 2
–++- max_n 0 0 1 0 0 1
–++- n 8 (4, 12) 3 (1, 6) 6 (2, 11) 3 (1, 5) 2 (1, 5) 3 (1, 5)
–++- n_unique 7 (3, 11) 3 (1, 6) 5 (2, 10) 3 (1, 5) 2 (0, 4) 2 (1, 5)
–++- post_p NA (NA, NA) 0.39 (0.23, 0.62) 0.83 (0.55, 0.97) 0.38 (0.23, 0.58) 0.33 (0.18, 0.48) 0.35 (0.2, 0.51)
–++- rate 0.086 (0.044, 0.164) 0.157 (0.078, 0.455) 0.041 (0.012, 0.094) 0.175 (0.079, 0.588) 0.264 (0.118, 0.883) 0.209 (0.105, 0.654)
–+++ graduation 0 21 110 2 0 325
–+++ futility 0 158 3 144 209 2
–+++ max_n 0 0 1 0 0 5
–+++ n 22 (15, 29) 5 (2, 13) 14 (3, 24) 5 (2, 12) 4 (2, 7) 9 (3, 23)
–+++ n_unique 20 (14, 27) 5 (2, 12) 13 (3, 22) 4 (2, 10) 3 (2, 6) 8 (3, 22)
–+++ post_p NA (NA, NA) 0.26 (0.1, 0.5) 0.87 (0.51, 0.99) 0.22 (0.1, 0.45) 0.19 (0.08, 0.36) 0.95 (0.62, 1)
–+++ rate 0.091 (0.065, 0.129) 0.157 (0.094, 0.354) 0.051 (0.028, 0.09) 0.179 (0.107, 0.408) 0.244 (0.14, 0.643) 0.038 (0.018, 0.074)
-+— graduation 0 255 2 191 191 13
-+— futility 0 3 79 18 36 12
-+— max_n 0 241 20 104 24 46
-+— n 28 (21, 37) 4 (0, 12) 5 (3, 11) 16 (8, 28) 17 (8, 30) 5 (3, 13)
-+— n_unique 25 (18, 34) 3 (0, 11) 5 (2, 10) 14 (8, 26) 16 (7, 28) 5 (2, 11)
-+— post_p NA (NA, NA) 0.69 (0.35, 0.93) 0.17 (0.06, 0.34) 0.97 (0.72, 1) 0.97 (0.74, 1) 0.17 (0.06, 0.34)
-+— rate 0.096 (0.072, 0.138) 0.061 (0.029, 0.172) 0.202 (0.121, 0.437) 0.039 (0.024, 0.067) 0.038 (0.023, 0.064) 0.204 (0.125, 0.41)
-+–+ graduation 0 252 7 180 179 297
-+–+ futility 0 8 80 62 118 12
-+–+ max_n 0 239 20 102 22 44
-+–+ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-+–+ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-+–+ post_p NA (NA, NA) 0.48 (0.48, 0.48) 0.48 (0.48, 0.49) NA (NA, NA) 0.5 (0.5, 0.5) NA (NA, NA)
-+–+ rate 0.191 (0, 0.698) 0.159 (0, 0.381) 0.283 (0.02, 0.817) 0.06 (0, 0.141) 0.063 (0, 0.287) 0.064 (0, 0.157)
-+-+- graduation 0 236 84 190 185 13
-+-+- futility 0 32 79 35 91 14
-+-+- max_n 0 231 21 104 24 46
-+-+- n 13 (8, 18) 2 (0, 6) 6 (2, 12) 7 (3, 13) 6 (2, 14) 4 (2, 7)
-+-+- n_unique 12 (7, 17) 2 (0, 6) 5 (1, 11) 6 (2, 12) 6 (2, 13) 3 (1, 7)
-+-+- post_p NA (NA, NA) 0.47 (0.22, 0.73) 0.55 (0.26, 0.85) 0.76 (0.4, 0.95) 0.73 (0.36, 0.94) 0.21 (0.07, 0.38)
-+-+- rate 0.074 (0.044, 0.122) 0.074 (0.032, 0.225) 0.059 (0.027, 0.174) 0.039 (0.016, 0.085) 0.042 (0.02, 0.102) 0.213 (0.109, 0.541)
-+-++ graduation 0 235 84 179 175 297
-+-++ futility 0 34 80 73 150 14
-+-++ max_n 0 230 21 102 22 44
-+-++ n 5 (2, 9) 1 (0, 3) 3 (0, 6) 3 (0, 6) 3 (1, 5) 1 (0, 5)
-+-++ n_unique 4 (2, 8) 1 (0, 3) 2 (0, 6) 2 (0, 6) 2 (0, 5) 1 (0, 4)
-+-++ post_p NA (NA, NA) 0.44 (0.3, 0.63) 0.48 (0.31, 0.7) 0.54 (0.35, 0.76) 0.55 (0.36, 0.77) 0.55 (0.37, 0.74)
-+-++ rate 0.078 (0.028, 0.182) 0.087 (0.022, 0.299) 0.062 (0.013, 0.215) 0.043 (0.009, 0.123) 0.043 (0, 0.128) 0.04 (0, 0.152)
-++– graduation 0 23 29 213 177 44
-++– futility 0 124 19 71 108 10
-++– max_n 0 0 0 0 0 1
-++– n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-++– n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-++– post_p NA (NA, NA) 0.47 (0.44, 0.53) 0.45 (0.43, 0.48) 0.47 (0.43, 0.52) 0.5 (0.5, 0.5) 0.49 (0.47, 0.52)
-++– rate 0.129 (0, 0.997) 0.101 (0, 0.528) 0.475 (0.089, 3.106) 0.056 (0, 2.733) 0.035 (0, 0.494) 0.189 (0, 1.078)
-++-+ graduation 0 23 31 203 171 319
-++-+ futility 0 130 22 104 145 10
-++-+ max_n 0 0 0 0 0 5
-++-+ n 3 (1, 5) 1 (0, 3) 2 (0, 4) 2 (0, 4) 2 (0, 4) 1 (0, 3)
-++-+ n_unique 2 (1, 5) 1 (0, 3) 1 (0, 3) 1 (0, 4) 1 (0, 4) 1 (0, 3)
-++-+ post_p NA (NA, NA) 0.45 (0.29, 0.58) 0.42 (0.27, 0.55) 0.6 (0.45, 0.79) 0.58 (0.43, 0.78) 0.58 (0.44, 0.79)
-++-+ rate 0.152 (0.053, 0.43) 0.164 (0.019, 0.67) 0.221 (0.083, 0.772) 0.039 (0, 0.174) 0.043 (0, 0.206) 0.039 (0, 0.178)
-+++- graduation 0 23 111 212 172 44
-+++- futility 0 154 19 90 153 12
-+++- max_n 0 0 1 0 0 1
-+++- n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-+++- n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-+++- post_p NA (NA, NA) 0.53 (0.49, 0.56) NA (NA, NA) 0.46 (0.41, 0.51) 0.49 (0.48, 0.53) 0.51 (0.49, 0.53)
-+++- rate 0.138 (0, 0.548) 0.143 (0, 3.254) 0.081 (0, 0.239) 0.039 (0, 0.207) 0.077 (0, 0.324) 0.167 (0, 5.454)
-++++ graduation 0 23 110 202 167 319
-++++ futility 0 159 22 119 178 12
-++++ max_n 0 0 1 0 0 5
-++++ n 3 (1, 6) 1 (0, 3) 2 (0, 4) 2 (0, 4) 2 (0, 4) 1 (0, 3)
-++++ n_unique 3 (1, 6) 1 (0, 3) 1 (0, 4) 1 (0, 4) 1 (0, 4) 1 (0, 3)
-++++ post_p NA (NA, NA) 0.42 (0.28, 0.55) 0.52 (0.36, 0.7) 0.56 (0.41, 0.75) 0.56 (0.41, 0.74) 0.54 (0.42, 0.71)
-++++ rate 0.104 (0.032, 0.315) 0.17 (0.042, 0.755) 0.064 (0, 0.265) 0.04 (0, 0.175) 0.04 (0, 0.171) 0.045 (0, 0.18)
+—- graduation 0 20 2 2 0 12
+—- futility 0 0 0 0 4 0
+—- max_n 0 0 0 0 0 0
+—- n 5 (2, 8) 2 (1, 5) 3 (1, 6) 2 (1, 5) 2 (1, 5) 2 (0, 5)
+—- n_unique 4 (2, 7) 2 (0, 5) 3 (1, 6) 2 (0, 5) 2 (0, 5) 2 (0, 4)
+—- post_p NA (NA, NA) 0.46 (0.28, 0.7) 0.48 (0.29, 0.76) 0.46 (0.29, 0.72) 0.49 (0.3, 0.73) 0.47 (0.3, 0.74)
+—- rate 0.111 (0.055, 0.22) 0.139 (0.053, 0.506) 0.123 (0.055, 0.413) 0.139 (0.041, 0.53) 0.129 (0.013, 0.475) 0.139 (0.04, 0.465)
+—+ graduation 0 20 7 2 0 316
+—+ futility 0 13 3 75 108 0
+—+ max_n 0 0 0 0 0 4
+—+ n 2 (0, 4) 1 (0, 3) 1 (0, 3) 1 (0, 3) 1 (0, 3) 1 (0, 3)
+—+ n_unique 1 (0, 4) 1 (0, 3) 1 (0, 3) 1 (0, 3) 1 (0, 3) 1 (0, 3)
+—+ post_p NA (NA, NA) 0.5 (0.38, 0.68) 0.45 (0.33, 0.63) 0.45 (0.35, 0.61) 0.44 (0.32, 0.61) 0.64 (0.47, 0.82)
+—+ rate 0.182 (0.047, 0.707) 0.158 (0, 0.732) 0.237 (0.081, 0.886) 0.201 (0.063, 0.716) 0.284 (0.088, 1.119) 0.041 (0, 0.224)
+–+- graduation 0 20 93 2 0 13
+–+- futility 0 46 0 34 79 2
+–+- max_n 0 0 1 0 0 0
+–+- n 8 (4, 13) 3 (1, 7) 6 (2, 11) 3 (1, 6) 3 (1, 5) 3 (1, 5)
+–+- n_unique 7 (4, 11) 3 (1, 6) 6 (2, 10) 3 (1, 5) 2 (1, 4) 2 (1, 5)
+–+- post_p NA (NA, NA) 0.38 (0.22, 0.62) 0.86 (0.52, 0.98) 0.36 (0.2, 0.57) 0.3 (0.17, 0.44) 0.34 (0.19, 0.53)
+–+- rate 0.086 (0.04, 0.161) 0.159 (0.075, 0.407) 0.038 (0.015, 0.097) 0.182 (0.085, 0.634) 0.263 (0.134, 0.733) 0.214 (0.105, 0.585)
+–++ graduation 0 20 93 2 0 316
+–++ futility 0 55 3 98 150 2
+–++ max_n 0 0 1 0 0 4
+–++ n 4 (1, 7) 2 (0, 5) 2 (1, 6) 2 (0, 4) 2 (0, 4) 1 (0, 4)
+–++ n_unique 3 (1, 6) 2 (0, 4) 2 (0, 5) 2 (0, 4) 2 (0, 3) 1 (0, 4)
+–++ post_p NA (NA, NA) 0.43 (0.29, 0.63) 0.61 (0.38, 0.83) 0.42 (0.26, 0.58) 0.37 (0.24, 0.49) 0.64 (0.42, 0.85)
+–++ rate 0.102 (0.035, 0.247) 0.151 (0.067, 0.585) 0.059 (0, 0.242) 0.188 (0.07, 0.701) 0.27 (0.099, 1.229) 0.046 (0, 0.18)
+-+– graduation 0 21 29 2 0 46
+-+– futility 0 122 0 87 130 0
+-+– max_n 0 0 0 0 0 1
+-+– n 1 (0, 3) 1 (0, 2) 1 (0, 3) 1 (0, 2) 1 (0, 2) 1 (0, 2)
+-+– n_unique 1 (0, 3) 1 (0, 2) 1 (0, 3) 1 (0, 2) 1 (0, 2) 1 (0, 2)
+-+– post_p NA (NA, NA) 0.5 (0.37, 0.66) 0.47 (0.35, 0.63) 0.48 (0.38, 0.65) 0.45 (0.34, 0.62) 0.48 (0.38, 0.65)
+-+– rate 0.161 (0.039, 0.746) 0.164 (0, 0.841) 0.207 (0.061, 1.002) 0.198 (0.047, 0.674) 0.262 (0.051, 1.355) 0.215 (0.041, 1.125)
+-+-+ graduation 0 21 31 2 0 325
+-+-+ futility 0 128 3 126 173 0
+-+-+ max_n 0 0 0 0 0 5
+-+-+ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+-+-+ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+-+-+ post_p NA (NA, NA) 0.55 (0.55, 0.55) 0.45 (0.45, 0.45) 0.49 (0.46, 0.5) 0.5 (0.5, 0.5) NA (NA, NA)
+-+-+ rate 0.133 (0, 1.503) 0.143 (0, 0.615) 0.203 (0, 0.853) 0.217 (0.097, 0.775) 0.182 (0.028, 1.645) 0 (0, 0.113)
+-++- graduation 0 21 111 2 0 46
+-++- futility 0 153 0 109 179 2
+-++- max_n 0 0 1 0 0 1
+-++- n 25 (19, 33) 6 (2, 14) 22 (7, 31) 5 (3, 12) 4 (2, 7) 5 (2, 9)
+-++- n_unique 23 (16, 30) 5 (2, 12) 19 (7, 29) 5 (2, 11) 4 (2, 7) 4 (2, 8)
+-++- post_p NA (NA, NA) 0.24 (0.09, 0.52) 0.98 (0.84, 1) 0.21 (0.1, 0.43) 0.18 (0.08, 0.36) 0.2 (0.08, 0.4)
+-++- rate 0.084 (0.06, 0.111) 0.162 (0.095, 0.361) 0.039 (0.024, 0.063) 0.185 (0.109, 0.419) 0.252 (0.148, 0.605) 0.207 (0.121, 0.504)
+-+++ graduation 0 21 110 2 0 325
+-+++ futility 0 158 3 144 209 2
+-+++ max_n 0 0 1 0 0 5
+-+++ n 18 (12, 25) 5 (2, 12) 12 (3, 21) 4 (2, 10) 4 (2, 7) 7 (2, 19)
+-+++ n_unique 16 (11, 23) 4 (1, 11) 11 (3, 20) 4 (2, 9) 3 (2, 6) 6 (2, 18)
+-+++ post_p NA (NA, NA) 0.32 (0.14, 0.6) 0.8 (0.45, 0.98) 0.24 (0.1, 0.46) 0.2 (0.09, 0.36) 0.92 (0.62, 1)
+-+++ rate 0.095 (0.067, 0.135) 0.154 (0.083, 0.377) 0.059 (0.033, 0.11) 0.192 (0.11, 0.46) 0.246 (0.143, 0.557) 0.039 (0.018, 0.078)
++— graduation 0 22 2 230 197 12
++— futility 0 2 19 0 4 10
++— max_n 0 0 0 0 0 0
++— n 9 (5, 13) 3 (1, 6) 3 (1, 5) 5 (2, 10) 5 (2, 11) 3 (1, 5)
++— n_unique 7 (4, 12) 3 (1, 6) 2 (1, 5) 5 (2, 10) 5 (2, 10) 3 (1, 5)
++— post_p NA (NA, NA) 0.39 (0.22, 0.66) 0.34 (0.17, 0.55) 0.85 (0.54, 0.98) 0.86 (0.56, 0.98) 0.34 (0.19, 0.52)
++— rate 0.149 (0.094, 0.255) 0.161 (0.069, 0.483) 0.214 (0.098, 0.799) 0.039 (0.013, 0.098) 0.038 (0.015, 0.093) 0.217 (0.102, 0.575)
++–+ graduation 0 22 7 214 185 311
++–+ futility 0 15 22 63 95 10
++–+ max_n 0 0 0 0 0 4
++–+ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++–+ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++–+ post_p NA (NA, NA) 0.48 (0.48, 0.48) 0.48 (0.46, 0.5) 0.6 (0.6, 0.6) NA (NA, NA) 0.44 (0.44, 0.44)
++–+ rate 0.163 (0, 0.5) 0.163 (0, 0.796) 0.209 (0, 1.474) 0.165 (0.004, 0.252) 0.051 (0, 0.172) 0 (0, 0.212)
++-+- graduation 0 22 93 229 191 13
++-+- futility 0 47 19 28 74 12
++-+- max_n 0 0 1 0 0 0
++-+- n 1 (0, 2) 0 (0, 2) 0 (0, 2) 0 (0, 2) 0 (0, 2) 0 (0, 2)
++-+- n_unique 1 (0, 2) 0 (0, 2) 0 (0, 2) 0 (0, 2) 0 (0, 2) 0 (0, 2)
++-+- post_p NA (NA, NA) 0.47 (0.39, 0.58) 0.54 (0.43, 0.61) 0.55 (0.44, 0.65) 0.54 (0.43, 0.65) 0.45 (0.37, 0.55)
++-+- rate 0.113 (0, 0.488) 0.207 (0, 1.228) 0.061 (0, 0.353) 0.026 (0, 0.238) 0.05 (0, 0.244) 0.24 (0, 2.116)
++-++ graduation 0 22 93 213 181 311
++-++ futility 0 56 22 81 134 12
++-++ max_n 0 0 1 0 0 4
++-++ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++-++ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++-++ post_p NA (NA, NA) 0.48 (0.45, 0.53) NA (NA, NA) 0.52 (0.52, 0.52) 0.54 (0.54, 0.54) 0.53 (0.53, 0.53)
++-++ rate 0.19 (0.036, 1.21) 0.191 (0, 1.469) 0.094 (0, 0.951) 0.068 (0, 0.675) 0 (0, 0.083) 0 (0, 0.663)
+++– graduation 0 23 29 213 177 44
+++– futility 0 124 19 71 108 10
+++– max_n 0 0 0 0 0 1
+++– n 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1)
+++– n_unique 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1)
+++– post_p NA (NA, NA) 0.49 (0.45, 0.57) 0.51 (0.41, 0.56) 0.55 (0.49, 0.6) 0.53 (0.48, 0.58) 0.48 (0.44, 0.56)
+++– rate 0.23 (0, 2.174) 0.2 (0, 0.941) 0.24 (0, 1.065) 0.017 (0, 0.31) 0.035 (0, 0.214) 0.192 (0, 0.862)
+++-+ graduation 0 23 31 203 171 319
+++-+ futility 0 130 22 104 145 10
+++-+ max_n 0 0 0 0 0 5
+++-+ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++-+ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++-+ post_p NA (NA, NA) 0.5 (0.46, 0.5) 0.52 (0.43, 0.56) 0.46 (0.44, 0.57) 0.42 (0.42, 0.42) 0.58 (0.58, 0.58)
+++-+ rate 0.134 (0, 0.307) 0.16 (0, 0.429) 0.143 (0, 0.569) 0.065 (0, 0.387) 0.069 (0, 0.542) 0 (0, 0.134)
++++- graduation 0 23 111 212 172 44
++++- futility 0 154 19 90 153 12
++++- max_n 0 0 1 0 0 1
++++- n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++++- n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++++- post_p NA (NA, NA) NA (NA, NA) 0.48 (0.48, 0.48) 0.51 (0.49, 0.52) NA (NA, NA) NA (NA, NA)
++++- rate 0.124 (0, 1.351) 0.138 (0, 0.923) 0.112 (0, 1.572) 0.074 (0, 0.438) 0 (0, 0.204) 0.118 (0, 1.589)
+++++ graduation 0 23 110 202 167 319
+++++ futility 0 159 22 119 178 12
+++++ max_n 0 0 1 0 0 5
+++++ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++++ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++++ post_p NA (NA, NA) 0.44 (0.39, 0.48) NA (NA, NA) 0.45 (0.42, 0.58) 0.49 (0.44, 0.56) 0.53 (0.47, 0.59)
+++++ rate 0.109 (0, 0.448) 0.283 (0.078, 1.443) 0.142 (0, 0.973) 0.081 (0, 0.416) 0 (0, 0.16) 0.079 (0, 0.192)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates


Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:
signature var TC1 TC2 TC3 TC4 TC5
all count 20 2 2 12
all time_stop 5 (4, 8) 6 (4, 7) 6 (6, 7) 6 (5, 10)
all n_trt 32 (27, 47) 26 (25, 27) 27 (27, 27) 30 (27, 58)
all n_control 56 (42, 67) 60 (49, 72) 63 (60, 66) 62 (52, 89)
all post_p 0.93 (0.9, 0.97) 0.89 (0.89, 0.9) 0.95 (0.94, 0.96) 0.97 (0.9, 0.99)
all order 1 (1, 1.1) 1 (1, 1) 1.5 (1.1, 1.9) 1 (1, 2)
AR- & TP53- count 241 3 1 1
AR- & TP53- time_stop 7 (5, 15) 11 (10, 13) 10 (10, 10) 14 (14, 14)
AR- & TP53- n_trt 32 (25, 75) 28 (27, 36) 28 (28, 28) 28 (28, 28)
AR- & TP53- n_control 42 (29, 88) 68 (58, 76) 57 (57, 57) 81 (81, 81)
AR- & TP53- post_p 0.95 (0.88, 1) 1 (0.97, 1) 0.98 (0.98, 0.98) 0.86 (0.86, 0.86)
AR- & TP53- order 1 (1, 2) 1 (1, 1) 2 (2, 2) 2 (2, 2)
HRD+ count 2 228 197
HRD+ time_stop 28 (26, 30) 24 (16, 32) 24 (17, 33)
HRD+ n_trt 27 (26, 28) 28 (25, 43) 28 (25, 46)
HRD+ n_control 34 (33, 34) 35 (22, 57) 35 (22, 55)
HRD+ post_p 0.94 (0.94, 0.95) 0.99 (0.96, 1) 1 (0.96, 1)
HRD+ order 3 (2.2, 3.8) 2 (1, 4) 2 (1, 4)
TP53+ count 1 27 35
TP53+ time_stop 16 (16, 16) 15 (11, 26) 14 (11, 23)
TP53+ n_trt 25 (25, 25) 31 (25, 60) 28 (25, 40)
TP53+ n_control 50 (50, 50) 44 (33, 98) 42 (27, 70)
TP53+ post_p 0.9 (0.9, 0.9) 0.98 (0.94, 1) 0.99 (0.92, 1)
TP53+ order 2 (2, 2) 2 (1, 3.4) 2 (1, 3)
TEfus+ count 91 1
TEfus+ time_stop 15 (11, 27) 13 (13, 13)
TEfus+ n_trt 31 (25, 66) 26 (26, 26)
TEfus+ n_control 44 (29, 78) 33 (33, 33)
TEfus+ post_p 0.99 (0.94, 1) 0.94 (0.94, 0.94)
TEfus+ order 2 (1, 4) 3 (3, 3)
PI3K+ count 5 307
PI3K+ time_stop 13 (11, 17) 15 (10, 28)
PI3K+ n_trt 26 (25, 30) 38 (26, 78)
PI3K+ n_control 38 (31, 62) 46 (28, 95)
PI3K+ post_p 0.97 (0.89, 0.98) 1 (0.98, 1)
PI3K+ order 3 (2, 3.6) 2 (1, 3)
Futility:
signature var TC1 TC2 TC3 TC4 TC5
all count 4
all time_stop 10 (8, 14)
all n_trt 30 (28, 47)
all n_control 84 (72, 143)
all post_p 0.03 (0.02, 0.07)
all order 1 (1, 1)
AR- & TP53- count 1 60 19 34 3
AR- & TP53- time_stop 5 (5, 5) 18 (12, 32) 15 (11, 25) 16 (10, 20) 12 (10, 18)
AR- & TP53- n_trt 28 (28, 28) 30 (25, 58) 35 (26, 66) 28 (25, 51) 26 (25, 29)
AR- & TP53- n_control 26 (26, 26) 106 (66, 217) 92 (60, 169) 80 (51, 127) 68 (53, 110)
AR- & TP53- post_p 0.29 (0.29, 0.29) 0.02 (0, 0.14) 0.07 (0.01, 0.22) 0.06 (0, 0.25) 0.14 (0.03, 0.25)
AR- & TP53- order 1 (1, 1) 1 (1, 2) 1 (1, 2) 1 (1, 2) 1 (1, 1.8)
HRD+ count 2 19 10
HRD+ time_stop 32 (31, 34) 35 (26, 35) 32 (30, 35)
HRD+ n_trt 26 (25, 27) 26 (25, 34) 26 (25, 29)
HRD+ n_control 50 (40, 60) 58 (38, 71) 60 (52, 72)
HRD+ post_p 0.05 (0.04, 0.05) 0.07 (0.02, 0.2) 0.03 (0, 0.11)
HRD+ order 1.5 (1.1, 1.9) 2 (1, 3) 2 (1, 3.1)
TP53+ count 122 87 126
TP53+ time_stop 24 (16, 32) 24 (17, 33) 24 (16, 32)
TP53+ n_trt 34 (26, 52) 30 (25, 46) 27 (25, 36)
TP53+ n_control 80 (47, 118) 82 (50, 122) 80 (50, 117)
TP53+ post_p 0.04 (0.01, 0.14) 0.04 (0.01, 0.18) 0.02 (0, 0.16)
TP53+ order 2 (1, 3) 2 (1, 4) 2 (1, 3)
TEfus+ count 46 34 75 2
TEfus+ time_stop 27 (18, 35) 21 (15, 30) 22 (15, 31) 12 (12, 13)
TEfus+ n_trt 34 (26, 48) 30 (25, 39) 28 (25, 38) 26 (25, 26)
TEfus+ n_control 92 (55, 124) 61 (43, 103) 67 (44, 109) 32 (31, 33)
TEfus+ post_p 0.02 (0, 0.09) 0.03 (0, 0.09) 0.01 (0, 0.07) 0.11 (0.09, 0.13)
TEfus+ order 2 (1, 4) 1.5 (1, 3) 2 (1, 3) 1 (1, 1)
PI3K+ count 13 3 75 104
PI3K+ time_stop 23 (15, 33) 29 (18, 33) 23 (17, 31) 22 (16, 33)
PI3K+ n_trt 26 (25, 39) 25 (25, 27) 28 (25, 42) 28 (25, 37)
PI3K+ n_control 72 (46, 116) 113 (73, 119) 80 (49, 116) 71 (45, 118)
PI3K+ post_p 0.06 (0.02, 0.24) 0.08 (0.03, 0.19) 0.05 (0.01, 0.17) 0.02 (0, 0.14)
PI3K+ order 2 (1, 3.8) 2 (1.2, 2) 2 (1, 4) 2 (1, 4)


By subgroup combinations

Graduation:
signature treatment var —– —-+ —+- —++ –+– –+-+ –++- –+++ -+— -+–+ -+-+- -+-++ -++– -++-+ -+++- -++++ +—- +—+ +–+- +–++ +-+– +-+-+ +-++- +-+++ ++— ++–+ ++-+- ++-++ +++– +++-+ ++++- +++++
all TC1 count 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20
all TC1 time 5 (4, 8) 5 (4, 8) 5 (4, 8) 5 (4, 8) 5 (4, 8) 5 (4, 8) 5 (4, 8) 5 (4, 8) 5 (4, 8) 5 (4, 8) 5 (4, 8) 5 (4, 8) 5 (4, 8) 5 (4, 8) 5 (4, 8) 5 (4, 8) 5 (4, 8) 5 (4, 8) 5 (4, 8) 5 (4, 8) 5 (4, 8) 5 (4, 8) 5 (4, 8) 5 (4, 8) 5 (4, 8) 5 (4, 8) 5 (4, 8) 5 (4, 8) 5 (4, 8) 5 (4, 8) 5 (4, 8) 5 (4, 8)
all TC1 n 18 (16, 31) 2 (1, 5) 0 (0, 1) 1 (0, 3) 3 (1, 5) 1 (0, 3) 0 (0, 1) 0 (0, 2) 0 (0, 2) 0 (0, 0) 0 (0, 1) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 0) 1 (0, 2) 1 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC1 post_p 0.83 (0.68, 0.96) 0.55 (0.52, 0.59) 0.52 (0.5, 0.57) 0.53 (0.52, 0.55) 0.55 (0.51, 0.61) 0.55 (0.5, 0.61) 0.54 (0.54, 0.58) 0.56 (0.53, 0.59) 0.52 (0.51, 0.57) NA (NA, NA) 0.51 (0.5, 0.52) 0.51 (0.5, 0.51) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.52 (0.5, 0.54) NA (NA, NA) 0.54 (0.54, 0.54) 0.51 (0.51, 0.51) 0.54 (0.54, 0.55) NA (NA, NA) 0.55 (0.53, 0.59) 0.55 (0.51, 0.6) NA (NA, NA) NA (NA, NA) 0.6 (0.6, 0.6) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC1 r_prob 0.41 (0.41, 0.41) 0.22 (0.22, 0.22) 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0.31 (0.31, 0.31) 0.13 (0.13, 0.13) 0.18 (0.18, 0.18) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.14 (0.14, 0.14) 0.18 (0.18, 0.18) 0.14 (0.14, 0.14) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC1 rate 0.037 (0.008, 0.052) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0.077) 0 (0, 0.089) 0 (0, 1.264) 0 (0, 0.03) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0.377) 0 (0, 0.846) 0 (0, 0.482) 0 (0, 0) 0 (0, 0.12) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0.275 (0.275, 0.275) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC2 count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
all TC2 time 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7)
all TC2 n 10 (10, 11) 0 (0, 0) 0 (0, 0) 1 (1, 1) 2 (2, 3) 0 (0, 1) 0 (0, 1) 1 (1, 1) 2 (0, 3) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 2 (2, 3) 1 (0, 2) 0 (0, 1) 0 (0, 0) 4 (3, 5) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC2 post_p 0.63 (0.6, 0.66) NA (NA, NA) NA (NA, NA) 0.52 (0.52, 0.52) 0.55 (0.52, 0.58) 0.53 (0.53, 0.53) 0.54 (0.54, 0.54) 0.54 (0.54, 0.54) 0.56 (0.56, 0.56) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.57 (0.52, 0.62) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.52 (0.52, 0.52) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC2 r_prob 0.18 (0.18, 0.18) 0.03 (0.03, 0.03) 0.25 (0.25, 0.25) 0.03 (0.03, 0.03) 0.17 (0.17, 0.17) 0.07 (0.07, 0.07) 0.41 (0.41, 0.41) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0.29 (0.29, 0.29) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC2 rate 0.058 (0.035, 0.08) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0.099 (0.099, 0.099) 0 (0, 0) NA (NA, NA) 0.043 (0.009, 0.078) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC3 count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
all TC3 time 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7)
all TC3 n 6 (4, 7) 2 (1, 4) 0 (0, 0) 0 (0, 0) 2 (1, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 8 (8, 9) 0 (0, 0) 2 (2, 2) 1 (1, 1) 0 (0, 0) 0 (0, 1) 0 (0, 0) 1 (0, 2) 0 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 1) 1 (0, 2) 2 (1, 2) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC3 post_p 0.56 (0.52, 0.59) 0.5 (0.5, 0.51) NA (NA, NA) NA (NA, NA) 0.53 (0.52, 0.54) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.62 (0.58, 0.66) NA (NA, NA) NA (NA, NA) 0.5 (0.5, 0.5) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.61 (0.61, 0.61) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.53 (0.53, 0.53) 0.58 (0.58, 0.58) 0.51 (0.51, 0.51) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
all TC3 rate 0.095 (0.087, 0.103) 0.054 (0.011, 0.098) NA (NA, NA) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.016 (0.003, 0.029) NA (NA, NA) 0.124 (0.025, 0.223) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) 11.962 (11.962, 11.962) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0.064 (0.013, 0.115) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC5 count 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12
all TC5 time 6 (5, 10) 6 (5, 10) 6 (5, 10) 6 (5, 10) 6 (5, 10) 6 (5, 10) 6 (5, 10) 6 (5, 10) 6 (5, 10) 6 (5, 10) 6 (5, 10) 6 (5, 10) 6 (5, 10) 6 (5, 10) 6 (5, 10) 6 (5, 10) 6 (5, 10) 6 (5, 10) 6 (5, 10) 6 (5, 10) 6 (5, 10) 6 (5, 10) 6 (5, 10) 6 (5, 10) 6 (5, 10) 6 (5, 10) 6 (5, 10) 6 (5, 10) 6 (5, 10) 6 (5, 10) 6 (5, 10) 6 (5, 10)
all TC5 n 4 (1, 11) 6 (4, 11) 0 (0, 1) 2 (0, 4) 2 (0, 3) 6 (1, 9) 0 (0, 0) 4 (3, 8) 0 (0, 4) 0 (0, 0) 0 (0, 1) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 0) 0 (0, 0) 1 (0, 2) 4 (2, 5) 0 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC5 post_p 0.55 (0.52, 0.61) 0.6 (0.51, 0.84) 0.52 (0.52, 0.52) 0.54 (0.52, 0.58) 0.54 (0.51, 0.74) 0.72 (0.51, 0.79) NA (NA, NA) 0.59 (0.54, 0.72) 0.52 (0.51, 0.58) NA (NA, NA) 0.54 (0.52, 0.55) 0.52 (0.51, 0.53) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.54 (0.51, 0.54) 0.55 (0.54, 0.57) 0.56 (0.53, 0.6) 0.54 (0.54, 0.55) 0.55 (0.55, 0.56) NA (NA, NA) NA (NA, NA) 0.54 (0.51, 0.63) 0.57 (0.52, 0.65) 0.52 (0.52, 0.52) NA (NA, NA) 0.52 (0.52, 0.52) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC5 r_prob 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0.38 (0.38, 0.38) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC5 rate 0.024 (0, 0.11) 0.045 (0, 0.082) 0 (0, 0) 0 (0, 0.014) 0 (0, 0.12) 0 (0, 0.068) NA (NA, NA) 0 (0, 0.035) 0 (0, 0.089) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0 (0, 0.067) 0 (0, 0.307) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA)
AR- & TP53- TC1 count 241 241 241 241 241 241 241 241
AR- & TP53- TC1 time 7 (5, 15) 7 (5, 15) 7 (5, 15) 7 (5, 15) 7 (5, 15) 7 (5, 15) 7 (5, 15) 7 (5, 15)
AR- & TP53- TC1 n 25 (20, 56) 3 (1, 9) 1 (0, 3) 1 (0, 4) 1 (0, 5) 0 (0, 0) 0 (0, 3) 0 (0, 1)
AR- & TP53- TC1 post_p 0.95 (0.83, 1) 0.58 (0.52, 0.8) 0.54 (0.51, 0.61) 0.53 (0.51, 0.65) 0.54 (0.51, 0.72) NA (NA, NA) 0.53 (0.51, 0.61) 0.54 (0.51, 0.57)
AR- & TP53- TC1 r_prob 0.41 (0.41, 0.41) 0.22 (0.22, 0.22) 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC1 rate 0.036 (0.013, 0.056) 0 (0, 0.086) 0 (0, 0.125) 0 (0, 0.097) 0 (0, 0.059) 0 (0, 0.461) 0 (0, 0.069) 0 (0, 0.072)
AR- & TP53- TC3 count 3 3 3 3 3 3 3 3
AR- & TP53- TC3 time 11 (10, 13) 11 (10, 13) 11 (10, 13) 11 (10, 13) 11 (10, 13) 11 (10, 13) 11 (10, 13) 11 (10, 13)
AR- & TP53- TC3 n 12 (9, 15) 3 (2, 4) 0 (0, 0) 1 (0, 3) 12 (7, 12) 0 (0, 0) 2 (2, 5) 2 (0, 2)
AR- & TP53- TC3 post_p 0.83 (0.73, 0.86) 0.58 (0.54, 0.69) NA (NA, NA) 0.55 (0.54, 0.56) 0.76 (0.74, 0.88) NA (NA, NA) 0.78 (0.62, 0.94) 0.54 (0.54, 0.54)
AR- & TP53- TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
AR- & TP53- TC3 rate 0.029 (0.006, 0.053) 0.065 (0.013, 0.116) NA (NA, NA) 0.048 (0.01, 0.087) 0.011 (0.002, 0.011) NA (NA, NA) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC4 count 1 1 1 1 1 1 1 1
AR- & TP53- TC4 time 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10)
AR- & TP53- TC4 n 18 (18, 18) 2 (2, 2) 0 (0, 0) 1 (1, 1) 2 (2, 2) 0 (0, 0) 4 (4, 4) 1 (1, 1)
AR- & TP53- TC4 post_p 0.85 (0.85, 0.85) 0.58 (0.58, 0.58) NA (NA, NA) 0.54 (0.54, 0.54) 0.68 (0.68, 0.68) NA (NA, NA) 0.62 (0.62, 0.62) 0.57 (0.57, 0.57)
AR- & TP53- TC4 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
AR- & TP53- TC4 rate 0.054 (0.054, 0.054) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC5 count 1 1 1 1 1 1 1 1
AR- & TP53- TC5 time 14 (14, 14) 14 (14, 14) 14 (14, 14) 14 (14, 14) 14 (14, 14) 14 (14, 14) 14 (14, 14) 14 (14, 14)
AR- & TP53- TC5 n 10 (10, 10) 8 (8, 8) 1 (1, 1) 5 (5, 5) 4 (4, 4) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC5 post_p 0.7 (0.7, 0.7) 0.72 (0.72, 0.72) 0.61 (0.61, 0.61) 0.54 (0.54, 0.54) 0.54 (0.54, 0.54) NA (NA, NA) NA (NA, NA) NA (NA, NA)
AR- & TP53- TC5 r_prob 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC5 rate 0.055 (0.055, 0.055) 0.048 (0.048, 0.048) 0 (0, 0) 0.082 (0.082, 0.082) 0.062 (0.062, 0.062) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC1 count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
HRD+ TC1 time 28 (26, 30) 28 (26, 30) 28 (26, 30) 28 (26, 30) 28 (26, 30) 28 (26, 30) 28 (26, 30) 28 (26, 30) 28 (26, 30) 28 (26, 30) 28 (26, 30) 28 (26, 30) 28 (26, 30) 28 (26, 30) 28 (26, 30) 28 (26, 30)
HRD+ TC1 n 12 (10, 14) 0 (0, 0) 4 (3, 5) 3 (2, 4) 0 (0, 0) 2 (2, 2) 0 (0, 0) 1 (0, 2) 3 (2, 4) 0 (0, 0) 2 (1, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 0)
HRD+ TC1 post_p 0.81 (0.74, 0.89) NA (NA, NA) 0.62 (0.57, 0.67) 0.53 (0.51, 0.56) NA (NA, NA) 0.64 (0.64, 0.64) NA (NA, NA) 0.52 (0.52, 0.52) 0.57 (0.56, 0.57) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC1 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC1 rate 0.051 (0.043, 0.058) NA (NA, NA) 0.019 (0.004, 0.035) 0.04 (0.034, 0.046) NA (NA, NA) 0.289 (0.058, 0.521) NA (NA, NA) 0 (0, 0) 0.054 (0.033, 0.075) NA (NA, NA) 0.92 (0.317, 1.524) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0) NA (NA, NA)
HRD+ TC3 count 228 228 228 228 228 228 228 228 228 228 228 228 228 228 228 228
HRD+ TC3 time 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32)
HRD+ TC3 n 14 (9, 22) 0 (0, 0) 6 (3, 10) 2 (0, 5) 0 (0, 0) 1 (0, 3) 0 (0, 0) 1 (0, 3) 4 (2, 8) 0 (0, 0) 0 (0, 2) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC3 post_p 0.9 (0.74, 0.99) NA (NA, NA) 0.72 (0.54, 0.87) 0.55 (0.51, 0.72) NA (NA, NA) 0.57 (0.52, 0.75) 0.56 (0.56, 0.56) 0.56 (0.51, 0.67) 0.71 (0.54, 0.93) NA (NA, NA) 0.57 (0.53, 0.67) NA (NA, NA) 0.55 (0.53, 0.58) 0.51 (0.51, 0.51) NA (NA, NA) 0.56 (0.56, 0.56)
HRD+ TC3 r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
HRD+ TC3 rate 0.035 (0.015, 0.059) 0 (0, 0) 0.03 (0, 0.062) 0.024 (0, 0.082) 0 (0, 4.128) 0.03 (0, 0.106) 0 (0, 1.046) 0 (0, 0.081) 0.031 (0, 0.082) 0.138 (0, 2.76) 0 (0, 0.189) 0 (0, 0.013) 0 (0, 0.139) 0 (0, 0.415) 0.053 (0, 0.844) 0 (0, 0.182)
HRD+ TC4 count 197 197 197 197 197 197 197 197 197 197 197 197 197 197 197 197
HRD+ TC4 time 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33)
HRD+ TC4 n 14 (9, 21) 0 (0, 0) 5 (3, 12) 2 (0, 4) 0 (0, 0) 1 (0, 4) 0 (0, 0) 1 (0, 3) 4 (2, 8) 0 (0, 0) 0 (0, 2) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC4 post_p 0.9 (0.75, 0.99) 0.5 (0.5, 0.5) 0.72 (0.52, 0.89) 0.57 (0.51, 0.7) 0.5 (0.5, 0.5) 0.57 (0.51, 0.7) NA (NA, NA) 0.55 (0.51, 0.68) 0.73 (0.56, 0.91) NA (NA, NA) 0.55 (0.52, 0.6) 0.57 (0.57, 0.57) 0.53 (0.52, 0.57) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC4 r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
HRD+ TC4 rate 0.033 (0.015, 0.057) 0.09 (0, 0.687) 0.033 (0, 0.065) 0.022 (0, 0.075) 0 (0, 0.348) 0.013 (0, 0.105) 0.122 (0.122, 0.122) 0 (0, 0.072) 0.031 (0, 0.082) 0.017 (0, 0.185) 0 (0, 0.187) 0 (0, 0) 0 (0, 0.204) 0.542 (0.2, 1.458) 0 (0, 1.353) 0.018 (0, 0.047)
TP53+ TC1 count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
TP53+ TC1 time 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16)
TP53+ TC1 n 6 (6, 6) 9 (9, 9) 0 (0, 0) 5 (5, 5) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 2 (2, 2) 3 (3, 3) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC1 post_p 0.7 (0.7, 0.7) 0.84 (0.84, 0.84) NA (NA, NA) 0.54 (0.54, 0.54) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.6 (0.6, 0.6) 0.64 (0.64, 0.64) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC1 r_prob 0.31 (0.31, 0.31) 0.13 (0.13, 0.13) 0.18 (0.18, 0.18) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC1 rate 0.042 (0.042, 0.042) 0.094 (0.094, 0.094) NA (NA, NA) 0.144 (0.144, 0.144) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.102 (0.102, 0.102) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC2 count 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27
TP53+ TC2 time 15 (11, 26) 15 (11, 26) 15 (11, 26) 15 (11, 26) 15 (11, 26) 15 (11, 26) 15 (11, 26) 15 (11, 26) 15 (11, 26) 15 (11, 26) 15 (11, 26) 15 (11, 26) 15 (11, 26) 15 (11, 26) 15 (11, 26) 15 (11, 26)
TP53+ TC2 n 7 (4, 14) 4 (2, 6) 2 (1, 6) 4 (2, 10) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 2) 0 (0, 2) 0 (0, 0) 9 (4, 18) 4 (2, 10) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC2 post_p 0.72 (0.53, 0.91) 0.54 (0.5, 0.73) 0.62 (0.55, 0.74) 0.66 (0.52, 0.85) NA (NA, NA) 0.53 (0.51, 0.55) NA (NA, NA) 0.57 (0.5, 0.62) 0.58 (0.57, 0.62) NA (NA, NA) 0.83 (0.62, 0.96) 0.73 (0.54, 0.9) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC2 r_prob 0.17 (0.17, 0.17) 0.07 (0.07, 0.07) 0.41 (0.41, 0.41) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC2 rate 0.069 (0.033, 0.099) 0.118 (0.054, 0.17) 0.028 (0, 0.107) 0.041 (0, 0.108) 0.593 (0.593, 0.593) 0 (0, 0.734) NA (NA, NA) 0 (0, 0.093) 0.136 (0, 0.841) 1.029 (0.383, 1.674) 0.035 (0, 0.062) 0.05 (0, 0.075) 0.795 (0.282, 1.059) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC5 count 35 35 35 35 35 35 35 35 35 35 35 35 35 35 35 35
TP53+ TC5 time 14 (11, 23) 14 (11, 23) 14 (11, 23) 14 (11, 23) 14 (11, 23) 14 (11, 23) 14 (11, 23) 14 (11, 23) 14 (11, 23) 14 (11, 23) 14 (11, 23) 14 (11, 23) 14 (11, 23) 14 (11, 23) 14 (11, 23) 14 (11, 23)
TP53+ TC5 n 5 (2, 8) 10 (4, 13) 1 (0, 3) 5 (2, 14) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 2) 0 (0, 1) 0 (0, 0) 3 (1, 5) 4 (2, 8) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC5 post_p 0.72 (0.52, 0.9) 0.91 (0.75, 0.99) 0.56 (0.52, 0.62) 0.78 (0.6, 0.95) NA (NA, NA) 0.56 (0.53, 0.57) NA (NA, NA) 0.57 (0.54, 0.6) 0.55 (0.52, 0.56) NA (NA, NA) 0.56 (0.52, 0.68) 0.71 (0.52, 0.88) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC5 r_prob 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC5 rate 0.051 (0, 0.121) 0.04 (0.004, 0.081) 0 (0, 0.156) 0.034 (0, 0.052) 0.335 (0.335, 0.335) 0 (0, 0.02) NA (NA, NA) 0 (0, 0.008) 0.145 (0, 0.567) 0.117 (0.117, 0.117) 0.066 (0, 0.148) 0.047 (0, 0.091) 0.194 (0.039, 0.205) NA (NA, NA) NA (NA, NA) 0 (0, 0)
TEfus+ TC2 count 91 91 91 91 91 91 91 91 91 91 91 91 91 91 91 91
TEfus+ TC2 time 15 (11, 27) 15 (11, 27) 15 (11, 27) 15 (11, 27) 15 (11, 27) 15 (11, 27) 15 (11, 27) 15 (11, 27) 15 (11, 27) 15 (11, 27) 15 (11, 27) 15 (11, 27) 15 (11, 27) 15 (11, 27) 15 (11, 27) 15 (11, 27)
TEfus+ TC2 n 2 (0, 5) 3 (1, 8) 3 (1, 6) 4 (2, 12) 3 (0, 6) 1 (0, 3) 0 (0, 0) 1 (0, 2) 3 (1, 6) 1 (0, 3) 8 (4, 16) 4 (2, 11) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 post_p 0.59 (0.52, 0.74) 0.6 (0.53, 0.8) 0.66 (0.54, 0.8) 0.66 (0.53, 0.87) 0.57 (0.51, 0.73) 0.55 (0.51, 0.62) NA (NA, NA) 0.53 (0.51, 0.61) 0.62 (0.52, 0.89) 0.57 (0.51, 0.73) 0.83 (0.62, 0.98) 0.68 (0.54, 0.87) 0.54 (0.51, 0.6) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC2 r_prob 0.25 (0.25, 0.25) 0.03 (0.03, 0.03) 0.41 (0.41, 0.41) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.29 (0.29, 0.29) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 rate 0 (0, 0.066) 0 (0, 0.072) 0.022 (0, 0.093) 0.036 (0, 0.077) 0.013 (0, 0.079) 0 (0, 0.078) 0.064 (0.013, 0.115) 0 (0, 0.158) 0.02 (0, 0.087) 0 (0, 0.098) 0.034 (0, 0.064) 0.039 (0, 0.094) 0 (0, 0.456) 0.032 (0.032, 0.032) 0.105 (0.056, 0.154) 0.18 (0.18, 0.18)
TEfus+ TC5 count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
TEfus+ TC5 time 13 (13, 13) 13 (13, 13) 13 (13, 13) 13 (13, 13) 13 (13, 13) 13 (13, 13) 13 (13, 13) 13 (13, 13) 13 (13, 13) 13 (13, 13) 13 (13, 13) 13 (13, 13) 13 (13, 13) 13 (13, 13) 13 (13, 13) 13 (13, 13)
TEfus+ TC5 n 1 (1, 1) 5 (5, 5) 0 (0, 0) 11 (11, 11) 5 (5, 5) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 1 (1, 1) 3 (3, 3) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC5 post_p 0.57 (0.57, 0.57) 0.51 (0.51, 0.51) NA (NA, NA) 0.88 (0.88, 0.88) 0.5 (0.5, 0.5) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.59 (0.59, 0.59) 0.74 (0.74, 0.74) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC5 r_prob 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC5 rate 0 (0, 0) 0.071 (0.071, 0.071) NA (NA, NA) 0.026 (0.026, 0.026) 0.08 (0.08, 0.08) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC2 count 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5
PI3K+ TC2 time 13 (11, 17) 13 (11, 17) 13 (11, 17) 13 (11, 17) 13 (11, 17) 13 (11, 17) 13 (11, 17) 13 (11, 17) 13 (11, 17) 13 (11, 17) 13 (11, 17) 13 (11, 17) 13 (11, 17) 13 (11, 17) 13 (11, 17) 13 (11, 17)
PI3K+ TC2 n 4 (3, 5) 3 (1, 5) 5 (3, 6) 4 (4, 6) 0 (0, 1) 1 (0, 2) 0 (0, 1) 2 (0, 2) 1 (0, 2) 1 (0, 3) 0 (0, 0) 4 (3, 10) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC2 post_p 0.55 (0.52, 0.85) 0.6 (0.55, 0.73) 0.55 (0.52, 0.7) 0.7 (0.52, 0.8) NA (NA, NA) 0.58 (0.52, 0.63) 0.51 (0.51, 0.51) 0.51 (0.5, 0.64) 0.52 (0.52, 0.52) 0.51 (0.51, 0.51) NA (NA, NA) 0.68 (0.59, 0.83) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC2 r_prob 0.03 (0.03, 0.03) 0.03 (0.03, 0.03) 0.07 (0.07, 0.07) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0.21 (0.21, 0.21) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC2 rate 0.057 (0, 0.068) 0 (0, 0.061) 0.115 (0.042, 0.142) 0.03 (0.007, 0.113) 0.475 (0.475, 0.475) 0 (0, 0.203) 0 (0, 0) 0 (0, 0.065) 0.239 (0.048, 0.362) 0 (0, 0.069) NA (NA, NA) 0.032 (0.007, 0.043) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC5 count 307 307 307 307 307 307 307 307 307 307 307 307 307 307 307 307
PI3K+ TC5 time 15 (10, 28) 15 (10, 28) 15 (10, 28) 15 (10, 28) 15 (10, 28) 15 (10, 28) 15 (10, 28) 15 (10, 28) 15 (10, 28) 15 (10, 28) 15 (10, 28) 15 (10, 28) 15 (10, 28) 15 (10, 28) 15 (10, 28) 15 (10, 28)
PI3K+ TC5 n 11 (6, 24) 5 (2, 11) 9 (4, 19) 6 (3, 15) 0 (0, 0) 1 (0, 3) 0 (0, 2) 0 (0, 2) 0 (0, 2) 1 (0, 3) 0 (0, 0) 5 (2, 11) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC5 post_p 0.85 (0.71, 0.99) 0.64 (0.52, 0.85) 0.9 (0.69, 1) 0.75 (0.53, 0.96) NA (NA, NA) 0.54 (0.51, 0.66) 0.57 (0.52, 0.67) 0.54 (0.51, 0.61) 0.58 (0.52, 0.7) 0.56 (0.51, 0.68) NA (NA, NA) 0.73 (0.54, 0.95) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC5 r_prob 0.38 (0.38, 0.38) 0.38 (0.38, 0.38) 0.33 (0.33, 0.33) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC5 rate 0.033 (0, 0.06) 0.027 (0, 0.075) 0.032 (0, 0.082) 0.032 (0, 0.07) 0 (0, 0.081) 0 (0, 0.072) 0 (0, 0.116) 0 (0, 0.097) 0 (0, 0.153) 0 (0, 0.133) 0 (0, 0.428) 0.028 (0, 0.075) 0 (0, 0) 0 (0, 0) 0 (0, 0.095) 0 (0, 0)
Futility:
signature treatment var —– —-+ —+- —++ –+– –+-+ –++- –+++ -+— -+–+ -+-+- -+-++ -++– -++-+ -+++- -++++ +—- +—+ +–+- +–++ +-+– +-+-+ +-++- +-+++ ++— ++–+ ++-+- ++-++ +++– +++-+ ++++- +++++
all TC4 count 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
all TC4 time 10 (8, 14) 10 (8, 14) 10 (8, 14) 10 (8, 14) 10 (8, 14) 10 (8, 14) 10 (8, 14) 10 (8, 14) 10 (8, 14) 10 (8, 14) 10 (8, 14) 10 (8, 14) 10 (8, 14) 10 (8, 14) 10 (8, 14) 10 (8, 14) 10 (8, 14) 10 (8, 14) 10 (8, 14) 10 (8, 14) 10 (8, 14) 10 (8, 14) 10 (8, 14) 10 (8, 14) 10 (8, 14) 10 (8, 14) 10 (8, 14) 10 (8, 14) 10 (8, 14) 10 (8, 14) 10 (8, 14) 10 (8, 14)
all TC4 n 6 (4, 9) 4 (2, 5) 0 (0, 2) 1 (0, 1) 3 (2, 7) 1 (1, 2) 0 (0, 1) 2 (0, 3) 2 (1, 4) 0 (0, 0) 4 (2, 4) 0 (0, 2) 0 (0, 0) 0 (0, 1) 0 (0, 0) 1 (0, 2) 0 (0, 2) 0 (0, 1) 0 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 2 (1, 3) 3 (2, 4) 1 (0, 5) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC4 post_p 0.29 (0.1, 0.38) 0.42 (0.31, 0.48) 0.41 (0.38, 0.44) 0.4 (0.38, 0.45) 0.36 (0.13, 0.45) 0.39 (0.35, 0.42) 0.47 (0.47, 0.47) 0.43 (0.42, 0.46) 0.47 (0.47, 0.47) NA (NA, NA) 0.48 (0.46, 0.48) 0.49 (0.49, 0.49) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.46 (0.43, 0.49) 0.49 (0.49, 0.49) NA (NA, NA) 0.43 (0.41, 0.45) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.41 (0.31, 0.42) 0.37 (0.33, 0.43) 0.47 (0.43, 0.49) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC4 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
all TC4 rate 0.261 (0.18, 0.292) 0.191 (0.051, 0.416) 0.278 (0.224, 0.332) 0.507 (0.373, 1.803) 0.41 (0.16, 0.792) 0.554 (0.411, 1.275) 1.098 (1.098, 1.098) 0.242 (0.204, 0.445) 0.064 (0.042, 0.094) NA (NA, NA) 0.077 (0.05, 0.151) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0 (0, 0.079) 0.283 (0.174, 0.392) 0 (0, 0) 0.289 (0.257, 0.32) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.492 (0.329, 1.792) 0.243 (0.166, 0.326) 0.05 (0.01, 0.314) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
AR- & TP53- TC1 count 1 1 1 1 1 1 1 1
AR- & TP53- TC1 time 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5)
AR- & TP53- TC1 n 24 (24, 24) 2 (2, 2) 0 (0, 0) 1 (1, 1) 0 (0, 0) 0 (0, 0) 1 (1, 1) 0 (0, 0)
AR- & TP53- TC1 post_p 0.45 (0.45, 0.45) 0.42 (0.42, 0.42) NA (NA, NA) 0.44 (0.44, 0.44) NA (NA, NA) NA (NA, NA) 0.49 (0.49, 0.49) NA (NA, NA)
AR- & TP53- TC1 r_prob 0.41 (0.41, 0.41) 0.22 (0.22, 0.22) 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC1 rate 0.085 (0.085, 0.085) 0.295 (0.295, 0.295) NA (NA, NA) 1.684 (1.684, 1.684) NA (NA, NA) NA (NA, NA) 0 (0, 0) NA (NA, NA)
AR- & TP53- TC2 count 60 60 60 60 60 60 60 60
AR- & TP53- TC2 time 18 (12, 32) 18 (12, 32) 18 (12, 32) 18 (12, 32) 18 (12, 32) 18 (12, 32) 18 (12, 32) 18 (12, 32)
AR- & TP53- TC2 n 14 (9, 32) 5 (2, 8) 1 (0, 2) 3 (0, 6) 4 (2, 7) 0 (0, 0) 2 (0, 6) 1 (0, 3)
AR- & TP53- TC2 post_p 0.09 (0.01, 0.33) 0.26 (0.1, 0.44) 0.44 (0.32, 0.49) 0.45 (0.37, 0.49) 0.31 (0.11, 0.45) NA (NA, NA) 0.45 (0.31, 0.49) 0.45 (0.35, 0.49)
AR- & TP53- TC2 r_prob 0.18 (0.18, 0.18) 0.03 (0.03, 0.03) 0.25 (0.25, 0.25) 0.03 (0.03, 0.03) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC2 rate 0.172 (0.13, 0.238) 0.195 (0.119, 0.561) 0.089 (0, 0.54) 0.107 (0.059, 0.386) 0.2 (0.101, 0.507) 0.341 (0.295, 0.386) 0.114 (0.056, 0.393) 0.082 (0, 0.591)
AR- & TP53- TC3 count 19 19 19 19 19 19 19 19
AR- & TP53- TC3 time 15 (11, 25) 15 (11, 25) 15 (11, 25) 15 (11, 25) 15 (11, 25) 15 (11, 25) 15 (11, 25) 15 (11, 25)
AR- & TP53- TC3 n 14 (7, 35) 5 (1, 9) 1 (0, 2) 3 (1, 5) 6 (3, 10) 0 (0, 0) 4 (2, 8) 2 (0, 3)
AR- & TP53- TC3 post_p 0.19 (0.05, 0.37) 0.37 (0.2, 0.44) 0.44 (0.34, 0.46) 0.41 (0.27, 0.46) 0.4 (0.28, 0.48) NA (NA, NA) 0.44 (0.25, 0.47) 0.42 (0.36, 0.47)
AR- & TP53- TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
AR- & TP53- TC3 rate 0.155 (0.125, 0.223) 0.182 (0.109, 0.547) 0.464 (0.093, 5.1) 0.157 (0.104, 0.389) 0.103 (0.059, 0.185) NA (NA, NA) 0.088 (0.022, 0.245) 0.108 (0.044, 0.295)
AR- & TP53- TC4 count 34 34 34 34 34 34 34 34
AR- & TP53- TC4 time 16 (10, 20) 16 (10, 20) 16 (10, 20) 16 (10, 20) 16 (10, 20) 16 (10, 20) 16 (10, 20) 16 (10, 20)
AR- & TP53- TC4 n 10 (5, 31) 4 (1, 6) 1 (0, 2) 2 (1, 4) 6 (2, 9) 0 (0, 0) 3 (1, 5) 2 (0, 4)
AR- & TP53- TC4 post_p 0.15 (0.03, 0.3) 0.29 (0.16, 0.43) 0.42 (0.39, 0.48) 0.36 (0.21, 0.45) 0.45 (0.31, 0.49) NA (NA, NA) 0.45 (0.36, 0.5) 0.45 (0.37, 0.49)
AR- & TP53- TC4 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
AR- & TP53- TC4 rate 0.198 (0.143, 0.423) 0.202 (0.127, 0.686) 0.278 (0.085, 1.11) 0.366 (0.1, 1.052) 0.085 (0.046, 0.236) 0 (0, 0) 0.077 (0, 0.196) 0.054 (0, 0.359)
AR- & TP53- TC5 count 3 3 3 3 3 3 3 3
AR- & TP53- TC5 time 12 (10, 18) 12 (10, 18) 12 (10, 18) 12 (10, 18) 12 (10, 18) 12 (10, 18) 12 (10, 18) 12 (10, 18)
AR- & TP53- TC5 n 13 (7, 14) 3 (1, 6) 1 (0, 1) 3 (1, 7) 5 (4, 7) 0 (0, 0) 2 (0, 4) 1 (0, 2)
AR- & TP53- TC5 post_p 0.36 (0.1, 0.4) 0.44 (0.41, 0.47) 0.42 (0.42, 0.42) 0.46 (0.45, 0.48) 0.19 (0.1, 0.35) NA (NA, NA) 0.34 (0.26, 0.42) 0.45 (0.45, 0.45)
AR- & TP53- TC5 r_prob 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC5 rate 0.155 (0.129, 0.344) 0.145 (0.125, 2.303) 4.845 (0.969, 8.72) 0.067 (0.04, 0.095) 0.382 (0.192, 0.582) NA (NA, NA) 0.245 (0.192, 0.298) 0.113 (0.023, 0.204)
HRD+ TC1 count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
HRD+ TC1 time 32 (31, 34) 32 (31, 34) 32 (31, 34) 32 (31, 34) 32 (31, 34) 32 (31, 34) 32 (31, 34) 32 (31, 34) 32 (31, 34) 32 (31, 34) 32 (31, 34) 32 (31, 34) 32 (31, 34) 32 (31, 34) 32 (31, 34) 32 (31, 34)
HRD+ TC1 n 6 (6, 7) 0 (0, 0) 6 (4, 8) 4 (2, 6) 0 (0, 0) 3 (3, 3) 0 (0, 0) 2 (0, 4) 4 (3, 4) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 1) 0 (0, 0) 0 (0, 0)
HRD+ TC1 post_p 0.34 (0.24, 0.45) NA (NA, NA) 0.34 (0.26, 0.43) 0.27 (0.23, 0.31) NA (NA, NA) 0.37 (0.35, 0.4) NA (NA, NA) 0.44 (0.44, 0.44) 0.25 (0.23, 0.26) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC1 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC1 rate 0.102 (0.084, 0.119) NA (NA, NA) 0.098 (0.096, 0.099) 0.149 (0.142, 0.156) NA (NA, NA) 0.4 (0.218, 0.582) NA (NA, NA) 0.12 (0.12, 0.12) 0.196 (0.188, 0.204) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0.494 (0.494, 0.494) NA (NA, NA) NA (NA, NA)
HRD+ TC2 count 19 19 19 19 19 19 19 19 19 19 19 19 19 19 19 19
HRD+ TC2 time 35 (26, 35) 35 (26, 35) 35 (26, 35) 35 (26, 35) 35 (26, 35) 35 (26, 35) 35 (26, 35) 35 (26, 35) 35 (26, 35) 35 (26, 35) 35 (26, 35) 35 (26, 35) 35 (26, 35) 35 (26, 35) 35 (26, 35) 35 (26, 35)
HRD+ TC2 n 8 (6, 11) 0 (0, 0) 7 (6, 10) 3 (1, 5) 0 (0, 0) 2 (1, 4) 0 (0, 0) 2 (0, 4) 4 (2, 6) 0 (0, 0) 0 (0, 2) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC2 post_p 0.14 (0.07, 0.28) NA (NA, NA) 0.4 (0.3, 0.48) 0.39 (0.33, 0.48) NA (NA, NA) 0.39 (0.25, 0.45) NA (NA, NA) 0.42 (0.37, 0.47) 0.3 (0.16, 0.43) NA (NA, NA) 0.48 (0.33, 0.49) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC2 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC2 rate 0.2 (0.132, 0.507) NA (NA, NA) 0.088 (0.062, 0.127) 0.103 (0.06, 0.379) 0.43 (0.43, 0.43) 0.496 (0.152, 1.385) NA (NA, NA) 0.175 (0.078, 1.285) 0.195 (0.133, 0.394) 0.046 (0.009, 0.083) 0.128 (0.102, 3.621) 0.094 (0.094, 0.094) 0.26 (0.07, 0.795) NA (NA, NA) 0.056 (0.011, 0.101) NA (NA, NA)
HRD+ TC5 count 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10
HRD+ TC5 time 32 (30, 35) 32 (30, 35) 32 (30, 35) 32 (30, 35) 32 (30, 35) 32 (30, 35) 32 (30, 35) 32 (30, 35) 32 (30, 35) 32 (30, 35) 32 (30, 35) 32 (30, 35) 32 (30, 35) 32 (30, 35) 32 (30, 35) 32 (30, 35)
HRD+ TC5 n 14 (8, 16) 0 (0, 1) 5 (3, 8) 1 (0, 3) 0 (0, 0) 0 (0, 2) 0 (0, 0) 0 (0, 3) 4 (2, 8) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC5 post_p 0.14 (0.07, 0.35) NA (NA, NA) 0.18 (0.08, 0.33) 0.42 (0.38, 0.47) NA (NA, NA) 0.37 (0.33, 0.4) NA (NA, NA) 0.48 (0.44, 0.5) 0.28 (0.11, 0.34) NA (NA, NA) 0.48 (0.47, 0.49) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC5 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC5 rate 0.195 (0.123, 0.256) 0.037 (0.007, 0.066) 0.228 (0.177, 0.516) 0.092 (0.067, 0.143) NA (NA, NA) 0.219 (0.021, 0.567) NA (NA, NA) 0.063 (0.038, 0.128) 0.261 (0.152, 0.594) NA (NA, NA) 0.366 (0.174, 0.799) NA (NA, NA) 0.378 (0.378, 0.378) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC1 count 122 122 122 122 122 122 122 122 122 122 122 122 122 122 122 122
TP53+ TC1 time 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32)
TP53+ TC1 n 7 (4, 15) 6 (2, 12) 2 (1, 5) 4 (2, 10) 0 (0, 0) 1 (0, 3) 0 (0, 0) 1 (0, 3) 0 (0, 2) 0 (0, 0) 4 (2, 10) 4 (2, 10) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC1 post_p 0.36 (0.15, 0.48) 0.33 (0.17, 0.47) 0.43 (0.29, 0.49) 0.33 (0.15, 0.46) NA (NA, NA) 0.43 (0.29, 0.48) NA (NA, NA) 0.42 (0.33, 0.48) 0.46 (0.37, 0.5) NA (NA, NA) 0.3 (0.15, 0.47) 0.33 (0.16, 0.47) 0.45 (0.44, 0.48) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC1 r_prob 0.31 (0.31, 0.31) 0.13 (0.13, 0.13) 0.18 (0.18, 0.18) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC1 rate 0.144 (0.101, 0.333) 0.181 (0.128, 0.518) 0.15 (0.095, 0.632) 0.158 (0.092, 0.356) 0.078 (0.016, 0.141) 0.205 (0.066, 0.857) 0 (0, 0.406) 0.207 (0.066, 0.755) 0.174 (0, 0.937) 0 (0, 0.443) 0.177 (0.115, 0.417) 0.168 (0.096, 0.448) 0.239 (0, 0.787) 0.159 (0.102, 0.217) 0.102 (0.02, 0.76) NA (NA, NA)
TP53+ TC3 count 87 87 87 87 87 87 87 87 87 87 87 87 87 87 87 87
TP53+ TC3 time 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33)
TP53+ TC3 n 7 (4, 13) 5 (3, 10) 2 (0, 4) 4 (1, 7) 0 (0, 0) 1 (0, 3) 0 (0, 0) 1 (0, 2) 0 (0, 2) 0 (0, 0) 5 (2, 9) 4 (2, 7) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC3 post_p 0.37 (0.16, 0.48) 0.33 (0.16, 0.47) 0.4 (0.25, 0.48) 0.3 (0.13, 0.45) NA (NA, NA) 0.47 (0.39, 0.5) NA (NA, NA) 0.47 (0.41, 0.5) 0.45 (0.29, 0.49) NA (NA, NA) 0.3 (0.15, 0.43) 0.28 (0.13, 0.44) 0.48 (0.48, 0.48) NA (NA, NA) 0.5 (0.5, 0.5) NA (NA, NA)
TP53+ TC3 r_prob 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TP53+ TC3 rate 0.14 (0.099, 0.279) 0.207 (0.135, 0.384) 0.218 (0.122, 0.667) 0.185 (0.111, 0.624) 0 (0, 0) 0.07 (0, 0.223) 0 (0, 0) 0.079 (0, 0.285) 0.256 (0, 0.543) 0.169 (0.034, 0.384) 0.179 (0.116, 0.509) 0.212 (0.131, 0.536) 0.11 (0, 0.285) 0.286 (0.286, 0.286) 0.042 (0.042, 0.042) 0.103 (0.021, 0.185)
TP53+ TC4 count 126 126 126 126 126 126 126 126 126 126 126 126 126 126 126 126
TP53+ TC4 time 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32)
TP53+ TC4 n 7 (3, 12) 5 (2, 10) 2 (0, 4) 3 (2, 6) 0 (0, 0) 1 (0, 3) 0 (0, 0) 1 (0, 3) 0 (0, 2) 0 (0, 0) 4 (2, 7) 3 (2, 6) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC4 post_p 0.37 (0.15, 0.48) 0.26 (0.13, 0.45) 0.4 (0.2, 0.47) 0.27 (0.1, 0.43) NA (NA, NA) 0.46 (0.4, 0.49) NA (NA, NA) 0.45 (0.39, 0.49) 0.44 (0.34, 0.49) NA (NA, NA) 0.23 (0.11, 0.41) 0.23 (0.11, 0.39) 0.49 (0.49, 0.49) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC4 r_prob 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TP53+ TC4 rate 0.151 (0.105, 0.295) 0.239 (0.153, 0.631) 0.262 (0.13, 1.032) 0.255 (0.129, 0.697) 0 (0, 0.047) 0.071 (0, 0.278) 0 (0, 0) 0.079 (0, 0.242) 0.284 (0.033, 1.319) 0.09 (0.035, 0.839) 0.267 (0.135, 0.708) 0.248 (0.13, 0.57) 0 (0, 0.156) 0 (0, 0) 0 (0, 0.052) 0 (0, 0)
TEfus+ TC1 count 46 46 46 46 46 46 46 46 46 46 46 46 46 46 46 46
TEfus+ TC1 time 27 (18, 35) 27 (18, 35) 27 (18, 35) 27 (18, 35) 27 (18, 35) 27 (18, 35) 27 (18, 35) 27 (18, 35) 27 (18, 35) 27 (18, 35) 27 (18, 35) 27 (18, 35) 27 (18, 35) 27 (18, 35) 27 (18, 35) 27 (18, 35)
TEfus+ TC1 n 1 (0, 4) 2 (0, 8) 2 (1, 5) 5 (2, 10) 1 (0, 8) 1 (0, 3) 0 (0, 0) 1 (0, 3) 3 (1, 6) 2 (0, 4) 4 (2, 11) 4 (2, 10) 0 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 post_p 0.44 (0.35, 0.49) 0.42 (0.29, 0.48) 0.38 (0.26, 0.48) 0.3 (0.1, 0.45) 0.39 (0.25, 0.49) 0.44 (0.35, 0.48) NA (NA, NA) 0.41 (0.28, 0.48) 0.38 (0.22, 0.47) 0.38 (0.32, 0.48) 0.28 (0.13, 0.44) 0.36 (0.2, 0.45) 0.42 (0.35, 0.5) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC1 r_prob 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0.18 (0.18, 0.18) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.14 (0.14, 0.14) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 rate 0.129 (0.06, 0.498) 0.098 (0.058, 0.205) 0.197 (0.101, 0.753) 0.164 (0.105, 0.374) 0.107 (0.064, 0.393) 0.12 (0.043, 0.312) NA (NA, NA) 0.204 (0.083, 1.011) 0.174 (0.103, 0.327) 0.232 (0.116, 0.689) 0.178 (0.119, 0.354) 0.156 (0.109, 0.315) 0.223 (0.072, 0.319) NA (NA, NA) 0.107 (0.107, 0.107) 0.418 (0.315, 0.521)
TEfus+ TC3 count 34 34 34 34 34 34 34 34 34 34 34 34 34 34 34 34
TEfus+ TC3 time 21 (15, 30) 21 (15, 30) 21 (15, 30) 21 (15, 30) 21 (15, 30) 21 (15, 30) 21 (15, 30) 21 (15, 30) 21 (15, 30) 21 (15, 30) 21 (15, 30) 21 (15, 30) 21 (15, 30) 21 (15, 30) 21 (15, 30) 21 (15, 30)
TEfus+ TC3 n 1 (0, 3) 3 (2, 7) 2 (1, 4) 3 (1, 6) 4 (2, 7) 1 (0, 4) 0 (0, 0) 1 (0, 2) 2 (1, 6) 1 (0, 3) 4 (2, 10) 4 (2, 8) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC3 post_p 0.44 (0.37, 0.49) 0.32 (0.17, 0.47) 0.41 (0.3, 0.47) 0.31 (0.15, 0.42) 0.4 (0.27, 0.46) 0.44 (0.35, 0.49) NA (NA, NA) 0.45 (0.4, 0.48) 0.43 (0.32, 0.48) 0.42 (0.29, 0.48) 0.35 (0.14, 0.42) 0.35 (0.15, 0.45) 0.42 (0.42, 0.42) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TEfus+ TC3 rate 0.232 (0.078, 3.044) 0.173 (0.105, 0.447) 0.237 (0.13, 0.518) 0.203 (0.109, 1.023) 0.09 (0.063, 0.3) 0.091 (0.011, 0.339) 0.061 (0.061, 0.061) 0.078 (0, 0.245) 0.206 (0.113, 0.442) 0.178 (0.077, 0.61) 0.175 (0.115, 0.374) 0.155 (0.096, 0.348) 0 (0, 0.147) 0.326 (0.326, 0.326) 0 (0, 0) NA (NA, NA)
TEfus+ TC4 count 75 75 75 75 75 75 75 75 75 75 75 75 75 75 75 75
TEfus+ TC4 time 22 (15, 31) 22 (15, 31) 22 (15, 31) 22 (15, 31) 22 (15, 31) 22 (15, 31) 22 (15, 31) 22 (15, 31) 22 (15, 31) 22 (15, 31) 22 (15, 31) 22 (15, 31) 22 (15, 31) 22 (15, 31) 22 (15, 31) 22 (15, 31)
TEfus+ TC4 n 1 (0, 3) 3 (1, 6) 2 (0, 4) 3 (2, 7) 4 (2, 7) 2 (0, 4) 0 (0, 0) 1 (0, 3) 2 (1, 4) 1 (0, 4) 4 (1, 6) 4 (2, 7) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC4 post_p 0.38 (0.3, 0.46) 0.28 (0.16, 0.43) 0.38 (0.23, 0.46) 0.28 (0.13, 0.41) 0.44 (0.28, 0.5) 0.44 (0.34, 0.5) 0.47 (0.47, 0.47) 0.45 (0.39, 0.49) 0.39 (0.18, 0.48) 0.39 (0.26, 0.46) 0.27 (0.11, 0.47) 0.24 (0.1, 0.44) 0.48 (0.44, 0.49) NA (NA, NA) NA (NA, NA) 0.44 (0.44, 0.44)
TEfus+ TC4 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TEfus+ TC4 rate 0.279 (0.144, 1.078) 0.276 (0.133, 0.894) 0.257 (0.143, 0.865) 0.212 (0.12, 0.513) 0.078 (0.036, 0.192) 0.067 (0.023, 0.295) 0.099 (0.02, 0.68) 0.079 (0, 0.245) 0.249 (0.111, 0.915) 0.277 (0.131, 1.47) 0.252 (0.136, 0.658) 0.24 (0.123, 0.524) 0.068 (0, 0.573) 0 (0, 0) NA (NA, NA) 0.08 (0.016, 0.144)
TEfus+ TC5 count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
TEfus+ TC5 time 12 (12, 13) 12 (12, 13) 12 (12, 13) 12 (12, 13) 12 (12, 13) 12 (12, 13) 12 (12, 13) 12 (12, 13) 12 (12, 13) 12 (12, 13) 12 (12, 13) 12 (12, 13) 12 (12, 13) 12 (12, 13) 12 (12, 13) 12 (12, 13)
TEfus+ TC5 n 0 (0, 1) 4 (3, 5) 0 (0, 1) 6 (4, 7) 2 (0, 4) 0 (0, 1) 0 (0, 0) 2 (0, 3) 3 (3, 3) 1 (1, 1) 2 (2, 3) 4 (3, 6) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC5 post_p NA (NA, NA) 0.48 (0.47, 0.49) 0.43 (0.43, 0.43) 0.46 (0.45, 0.46) 0.42 (0.42, 0.42) 0.42 (0.42, 0.42) NA (NA, NA) 0.47 (0.47, 0.47) 0.42 (0.41, 0.43) 0.42 (0.42, 0.42) 0.35 (0.26, 0.44) 0.43 (0.38, 0.48) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC5 r_prob 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC5 rate 1.586 (1.586, 1.586) 0.077 (0.063, 0.09) 15.262 (15.262, 15.262) 0.092 (0.084, 0.1) 0.185 (0.185, 0.185) 0.523 (0.523, 0.523) NA (NA, NA) 0.135 (0.135, 0.135) 0.193 (0.143, 0.244) 0.285 (0.274, 0.296) 0.244 (0.169, 0.319) 0.118 (0.105, 0.13) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC1 count 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13
PI3K+ TC1 time 23 (15, 33) 23 (15, 33) 23 (15, 33) 23 (15, 33) 23 (15, 33) 23 (15, 33) 23 (15, 33) 23 (15, 33) 23 (15, 33) 23 (15, 33) 23 (15, 33) 23 (15, 33) 23 (15, 33) 23 (15, 33) 23 (15, 33) 23 (15, 33)
PI3K+ TC1 n 5 (2, 10) 3 (1, 6) 7 (3, 15) 4 (0, 7) 0 (0, 0) 1 (0, 3) 1 (0, 2) 1 (0, 3) 0 (0, 2) 1 (0, 4) 0 (0, 0) 4 (2, 5) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC1 post_p 0.37 (0.27, 0.46) 0.36 (0.25, 0.42) 0.34 (0.27, 0.46) 0.36 (0.11, 0.44) NA (NA, NA) 0.44 (0.4, 0.48) 0.45 (0.41, 0.46) 0.41 (0.33, 0.45) 0.38 (0.33, 0.46) 0.43 (0.3, 0.44) NA (NA, NA) 0.31 (0.17, 0.43) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC1 r_prob 0.22 (0.22, 0.22) 0.22 (0.22, 0.22) 0.13 (0.13, 0.13) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.14 (0.14, 0.14) 0.14 (0.14, 0.14) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC1 rate 0.142 (0.107, 0.177) 0.125 (0.078, 0.181) 0.18 (0.135, 0.354) 0.188 (0.104, 0.419) NA (NA, NA) 0.084 (0.047, 0.349) 0.278 (0.198, 0.685) 0.2 (0.121, 2.371) 0.149 (0.051, 1.82) 0.31 (0.111, 0.751) NA (NA, NA) 0.156 (0.113, 0.586) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC2 count 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
PI3K+ TC2 time 29 (18, 33) 29 (18, 33) 29 (18, 33) 29 (18, 33) 29 (18, 33) 29 (18, 33) 29 (18, 33) 29 (18, 33) 29 (18, 33) 29 (18, 33) 29 (18, 33) 29 (18, 33) 29 (18, 33) 29 (18, 33) 29 (18, 33) 29 (18, 33)
PI3K+ TC2 n 6 (4, 6) 4 (1, 5) 4 (2, 8) 4 (2, 8) 0 (0, 0) 1 (0, 1) 1 (0, 1) 2 (0, 2) 1 (0, 1) 1 (0, 3) 0 (0, 0) 3 (2, 5) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC2 post_p 0.21 (0.21, 0.22) 0.37 (0.34, 0.4) 0.34 (0.18, 0.36) 0.46 (0.45, 0.47) NA (NA, NA) 0.44 (0.4, 0.48) 0.46 (0.45, 0.46) 0.45 (0.42, 0.48) 0.4 (0.39, 0.41) 0.42 (0.4, 0.43) NA (NA, NA) 0.32 (0.28, 0.41) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC2 r_prob 0.03 (0.03, 0.03) 0.03 (0.03, 0.03) 0.07 (0.07, 0.07) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0.21 (0.21, 0.21) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC2 rate 0.219 (0.136, 0.338) 0.082 (0.073, 0.092) 0.226 (0.209, 0.247) 0.106 (0.071, 0.118) NA (NA, NA) 0.117 (0.091, 0.143) 1.509 (0.595, 2.423) 0.106 (0.093, 0.118) 1.194 (0.697, 1.692) 0.14 (0.094, 0.186) NA (NA, NA) 0.197 (0.143, 0.314) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC3 count 75 75 75 75 75 75 75 75 75 75 75 75 75 75 75 75
PI3K+ TC3 time 23 (17, 31) 23 (17, 31) 23 (17, 31) 23 (17, 31) 23 (17, 31) 23 (17, 31) 23 (17, 31) 23 (17, 31) 23 (17, 31) 23 (17, 31) 23 (17, 31) 23 (17, 31) 23 (17, 31) 23 (17, 31) 23 (17, 31) 23 (17, 31)
PI3K+ TC3 n 6 (2, 12) 4 (1, 7) 5 (3, 10) 4 (2, 7) 0 (0, 0) 2 (0, 4) 1 (0, 3) 1 (0, 2) 0 (0, 2) 1 (0, 3) 0 (0, 0) 3 (2, 6) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC3 post_p 0.27 (0.12, 0.45) 0.3 (0.15, 0.46) 0.33 (0.14, 0.46) 0.29 (0.14, 0.46) NA (NA, NA) 0.46 (0.39, 0.5) 0.48 (0.41, 0.5) 0.46 (0.38, 0.49) 0.44 (0.34, 0.48) 0.43 (0.34, 0.48) NA (NA, NA) 0.29 (0.13, 0.44) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC3 rate 0.177 (0.104, 0.394) 0.171 (0.088, 0.531) 0.201 (0.142, 0.394) 0.179 (0.102, 0.573) 0 (0, 0) 0.068 (0.023, 0.11) 0.1 (0, 0.845) 0.079 (0, 0.244) 0.263 (0.066, 0.548) 0.208 (0.081, 0.722) 4.319 (0.999, 7.639) 0.213 (0.107, 0.56) 0.117 (0.023, 0.21) 0.625 (0.125, 1.125) 0.054 (0, 0.175) 0.156 (0.031, 0.195)
PI3K+ TC4 count 104 104 104 104 104 104 104 104 104 104 104 104 104 104 104 104
PI3K+ TC4 time 22 (16, 33) 22 (16, 33) 22 (16, 33) 22 (16, 33) 22 (16, 33) 22 (16, 33) 22 (16, 33) 22 (16, 33) 22 (16, 33) 22 (16, 33) 22 (16, 33) 22 (16, 33) 22 (16, 33) 22 (16, 33) 22 (16, 33) 22 (16, 33)
PI3K+ TC4 n 5 (2, 10) 3 (1, 6) 5 (2, 10) 3 (1, 6) 0 (0, 0) 2 (0, 4) 1 (0, 3) 1 (0, 3) 1 (0, 2) 2 (0, 3) 0 (0, 0) 4 (2, 6) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC4 post_p 0.22 (0.07, 0.4) 0.28 (0.13, 0.42) 0.25 (0.12, 0.46) 0.25 (0.12, 0.41) NA (NA, NA) 0.46 (0.35, 0.49) 0.47 (0.42, 0.49) 0.47 (0.41, 0.5) 0.44 (0.37, 0.49) 0.39 (0.26, 0.46) NA (NA, NA) 0.26 (0.12, 0.44) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC4 r_prob 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC4 rate 0.219 (0.125, 0.494) 0.237 (0.115, 0.64) 0.256 (0.143, 0.616) 0.244 (0.129, 0.756) 0.067 (0.013, 0.12) 0.078 (0.024, 0.279) 0.069 (0, 0.268) 0.073 (0, 0.288) 0.305 (0.09, 0.987) 0.318 (0.156, 1.591) 0.567 (0.169, 0.966) 0.226 (0.121, 0.446) 0 (0, 0.18) 0 (0, 0) NA (NA, NA) 0 (0, 0)