Simulation scenario 7, CR phase

Setting description

Several treatments more effective in distinctive signatures: (TC1, AR- & TP53-); (TC2, TEfus+); (TC3 and TC4, HRD+); (TC5,PI3K )

Simulations setting

Survival curves (by signature)

PFS distributions (by signature)

Treatment effects (by signature)

signature	var	Other	TC1	TC2	TC3	TC4	TC5
all	param	scale = 0.112, shape = 1.05	scale = 0.086, shape = 1.05	scale = 0.132, shape = 1.05	scale = 0.133, shape = 1.05	scale = 0.178, shape = 1.05	scale = 0.128, shape = 1.05
all	summary	mean = 8.8, median = 6.3	mean = 11.4, median = 8.2	mean = 7.4, median = 5.3	mean = 7.4, median = 5.3	mean = 5.5, median = 4	mean = 7.7, median = 5.5
all	effect	af = 1, hr = 1	af = 1.29, hr = 0.76	af = 0.84, hr = 1.19	af = 0.84, hr = 1.21	af = 0.63, hr = 1.63	af = 0.88, hr = 1.15
AR- & TP53-	param	scale = 0.112, shape = 1.05	scale = 0.05, shape = 1.05	scale = 0.159, shape = 1.05	scale = 0.132, shape = 1.05	scale = 0.18, shape = 1.05	scale = 0.149, shape = 1.05
AR- & TP53-	summary	mean = 8.8, median = 6.3	mean = 19.8, median = 14.2	mean = 6.2, median = 4.4	mean = 7.4, median = 5.3	mean = 5.5, median = 3.9	mean = 6.6, median = 4.7
AR- & TP53-	effect	af = 1, hr = 1	af = 2.25, hr = 0.43	af = 0.7, hr = 1.45	af = 0.84, hr = 1.2	af = 0.62, hr = 1.65	af = 0.75, hr = 1.35
HRD+	param	scale = 0.112, shape = 1.05	scale = 0.086, shape = 1.05	scale = 0.135, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.153, shape = 1.05
HRD+	summary	mean = 8.8, median = 6.3	mean = 11.4, median = 8.2	mean = 7.2, median = 5.2	mean = 25, median = 18	mean = 25, median = 18	mean = 6.4, median = 4.6
HRD+	effect	af = 1, hr = 1	af = 1.3, hr = 0.76	af = 0.82, hr = 1.23	af = 2.85, hr = 0.33	af = 2.85, hr = 0.33	af = 0.73, hr = 1.39
TP53+	param	scale = 0.112, shape = 1.05	scale = 0.133, shape = 1.05	scale = 0.095, shape = 1.05	scale = 0.14, shape = 1.05	scale = 0.184, shape = 1.05	scale = 0.09, shape = 1.05
TP53+	summary	mean = 8.8, median = 6.3	mean = 7.4, median = 5.3	mean = 10.4, median = 7.5	mean = 7, median = 5	mean = 5.3, median = 3.8	mean = 10.9, median = 7.8
TP53+	effect	af = 1, hr = 1	af = 0.84, hr = 1.2	af = 1.18, hr = 0.84	af = 0.79, hr = 1.27	af = 0.61, hr = 1.69	af = 1.24, hr = 0.8
TEfus+	param	scale = 0.112, shape = 1.05	scale = 0.116, shape = 1.05	scale = 0.049, shape = 1.05	scale = 0.135, shape = 1.05	scale = 0.183, shape = 1.05	scale = 0.107, shape = 1.05
TEfus+	summary	mean = 8.8, median = 6.3	mean = 8.4, median = 6.1	mean = 19.9, median = 14.3	mean = 7.3, median = 5.2	mean = 5.4, median = 3.9	mean = 9.1, median = 6.6
TEfus+	effect	af = 1, hr = 1	af = 0.96, hr = 1.04	af = 2.27, hr = 0.42	af = 0.83, hr = 1.22	af = 0.61, hr = 1.68	af = 1.04, hr = 0.96
PI3K+	param	scale = 0.112, shape = 1.05	scale = 0.107, shape = 1.05	scale = 0.117, shape = 1.05	scale = 0.145, shape = 1.05	scale = 0.198, shape = 1.05	scale = 0.038, shape = 1.05
PI3K+	summary	mean = 8.8, median = 6.3	mean = 9.2, median = 6.6	mean = 8.4, median = 6	mean = 6.8, median = 4.9	mean = 5, median = 3.6	mean = 26.1, median = 18.8
PI3K+	effect	af = 1, hr = 1	af = 1.04, hr = 0.96	af = 0.96, hr = 1.05	af = 0.77, hr = 1.31	af = 0.56, hr = 1.83	af = 2.97, hr = 0.32

Survival curves (by subgroup)

PFS distributions (by subgroup)

Treatment effects (by subgroup)

subtype	var	Other	TC1	TC2	TC3	TC4	TC5
—–	param	scale = 0.112, shape = 1.05	scale = 0.042, shape = 1.05	scale = 0.182, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.182, shape = 1.05
—–	summary	mean = 8.8, median = 6.3	mean = 23.4, median = 16.9	mean = 5.4, median = 3.9	mean = 6.3, median = 4.5	mean = 4.5, median = 3.3	mean = 5.4, median = 3.9
—–	effect	af = 1, hr = 1	af = 2.67, hr = 0.36	af = 0.61, hr = 1.67	af = 0.71, hr = 1.43	af = 0.52, hr = 2	af = 0.61, hr = 1.67
—-+	param	scale = 0.112, shape = 1.05	scale = 0.05, shape = 1.05	scale = 0.182, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.037, shape = 1.05
—-+	summary	mean = 8.8, median = 6.3	mean = 19.4, median = 14	mean = 5.4, median = 3.9	mean = 6.3, median = 4.5	mean = 4.5, median = 3.3	mean = 26.6, median = 19.1
—-+	effect	af = 1, hr = 1	af = 2.21, hr = 0.43	af = 0.61, hr = 1.67	af = 0.71, hr = 1.43	af = 0.52, hr = 2	af = 3.03, hr = 0.31
—+-	param	scale = 0.112, shape = 1.05	scale = 0.058, shape = 1.05	scale = 0.042, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.182, shape = 1.05
—+-	summary	mean = 8.8, median = 6.3	mean = 17, median = 12.2	mean = 23.4, median = 16.9	mean = 6.3, median = 4.5	mean = 4.5, median = 3.3	mean = 5.4, median = 3.9
—+-	effect	af = 1, hr = 1	af = 1.94, hr = 0.5	af = 2.67, hr = 0.36	af = 0.71, hr = 1.43	af = 0.52, hr = 2	af = 0.61, hr = 1.67
—++	param	scale = 0.112, shape = 1.05	scale = 0.064, shape = 1.05	scale = 0.05, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.037, shape = 1.05
—++	summary	mean = 8.8, median = 6.3	mean = 15.4, median = 11.1	mean = 19.4, median = 14	mean = 6.3, median = 4.5	mean = 4.5, median = 3.3	mean = 26.6, median = 19.1
—++	effect	af = 1, hr = 1	af = 1.75, hr = 0.56	af = 2.21, hr = 0.43	af = 0.71, hr = 1.43	af = 0.52, hr = 2	af = 3.03, hr = 0.31
–+–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
–+–	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
–+–	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–+-+	param	scale = 0.112, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.182, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.037, shape = 1.05
–+-+	summary	mean = 8.8, median = 6.3	mean = 7.1, median = 5.1	mean = 5.4, median = 3.9	mean = 6.3, median = 4.5	mean = 4.5, median = 3.3	mean = 26.6, median = 19.1
–+-+	effect	af = 1, hr = 1	af = 0.81, hr = 1.25	af = 0.61, hr = 1.67	af = 0.71, hr = 1.43	af = 0.52, hr = 2	af = 3.03, hr = 0.31
–++-	param	scale = 0.112, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.182, shape = 1.05
–++-	summary	mean = 8.8, median = 6.3	mean = 7.1, median = 5.1	mean = 25, median = 18	mean = 6.3, median = 4.5	mean = 4.5, median = 3.3	mean = 5.4, median = 3.9
–++-	effect	af = 1, hr = 1	af = 0.81, hr = 1.25	af = 2.85, hr = 0.33	af = 0.71, hr = 1.43	af = 0.52, hr = 2	af = 0.61, hr = 1.67
–+++	param	scale = 0.112, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.05, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.037, shape = 1.05
–+++	summary	mean = 8.8, median = 6.3	mean = 7.1, median = 5.1	mean = 19.4, median = 14	mean = 6.3, median = 4.5	mean = 4.5, median = 3.3	mean = 26.6, median = 19.1
–+++	effect	af = 1, hr = 1	af = 0.81, hr = 1.25	af = 2.21, hr = 0.43	af = 0.71, hr = 1.43	af = 0.52, hr = 2	af = 3.03, hr = 0.31
-+—	param	scale = 0.112, shape = 1.05	scale = 0.058, shape = 1.05	scale = 0.182, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.182, shape = 1.05
-+—	summary	mean = 8.8, median = 6.3	mean = 17, median = 12.2	mean = 5.4, median = 3.9	mean = 25, median = 18	mean = 25, median = 18	mean = 5.4, median = 3.9
-+—	effect	af = 1, hr = 1	af = 1.94, hr = 0.5	af = 0.61, hr = 1.67	af = 2.85, hr = 0.33	af = 2.85, hr = 0.33	af = 0.61, hr = 1.67
-+–+	param	scale = 0.112, shape = 1.05	scale = 0.058, shape = 1.05	scale = 0.182, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.039, shape = 1.05
-+–+	summary	mean = 8.8, median = 6.3	mean = 17, median = 12.2	mean = 5.4, median = 3.9	mean = 25, median = 18	mean = 25, median = 18	mean = 25, median = 18
-+–+	effect	af = 1, hr = 1	af = 1.94, hr = 0.5	af = 0.61, hr = 1.67	af = 2.85, hr = 0.33	af = 2.85, hr = 0.33	af = 2.85, hr = 0.33
-+-+-	param	scale = 0.112, shape = 1.05	scale = 0.071, shape = 1.05	scale = 0.058, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.182, shape = 1.05
-+-+-	summary	mean = 8.8, median = 6.3	mean = 13.8, median = 9.9	mean = 17, median = 12.2	mean = 25, median = 18	mean = 25, median = 18	mean = 5.4, median = 3.9
-+-+-	effect	af = 1, hr = 1	af = 1.56, hr = 0.62	af = 1.94, hr = 0.5	af = 2.85, hr = 0.33	af = 2.85, hr = 0.33	af = 0.61, hr = 1.67
-+-++	param	scale = 0.112, shape = 1.05	scale = 0.071, shape = 1.05	scale = 0.058, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.039, shape = 1.05
-+-++	summary	mean = 8.8, median = 6.3	mean = 13.8, median = 9.9	mean = 17, median = 12.2	mean = 25, median = 18	mean = 25, median = 18	mean = 25, median = 18
-+-++	effect	af = 1, hr = 1	af = 1.56, hr = 0.62	af = 1.94, hr = 0.5	af = 2.85, hr = 0.33	af = 2.85, hr = 0.33	af = 2.85, hr = 0.33
-++–	param	scale = 0.112, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.182, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.182, shape = 1.05
-++–	summary	mean = 8.8, median = 6.3	mean = 7.1, median = 5.1	mean = 5.4, median = 3.9	mean = 25, median = 18	mean = 25, median = 18	mean = 5.4, median = 3.9
-++–	effect	af = 1, hr = 1	af = 0.81, hr = 1.25	af = 0.61, hr = 1.67	af = 2.85, hr = 0.33	af = 2.85, hr = 0.33	af = 0.61, hr = 1.67
-++-+	param	scale = 0.112, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.182, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.039, shape = 1.05
-++-+	summary	mean = 8.8, median = 6.3	mean = 7.1, median = 5.1	mean = 5.4, median = 3.9	mean = 25, median = 18	mean = 25, median = 18	mean = 25, median = 18
-++-+	effect	af = 1, hr = 1	af = 0.81, hr = 1.25	af = 0.61, hr = 1.67	af = 2.85, hr = 0.33	af = 2.85, hr = 0.33	af = 2.85, hr = 0.33
-+++-	param	scale = 0.112, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.058, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.182, shape = 1.05
-+++-	summary	mean = 8.8, median = 6.3	mean = 7.1, median = 5.1	mean = 17, median = 12.2	mean = 25, median = 18	mean = 25, median = 18	mean = 5.4, median = 3.9
-+++-	effect	af = 1, hr = 1	af = 0.81, hr = 1.25	af = 1.94, hr = 0.5	af = 2.85, hr = 0.33	af = 2.85, hr = 0.33	af = 0.61, hr = 1.67
-++++	param	scale = 0.112, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.058, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.039, shape = 1.05
-++++	summary	mean = 8.8, median = 6.3	mean = 7.1, median = 5.1	mean = 17, median = 12.2	mean = 25, median = 18	mean = 25, median = 18	mean = 25, median = 18
-++++	effect	af = 1, hr = 1	af = 0.81, hr = 1.25	af = 1.94, hr = 0.5	af = 2.85, hr = 0.33	af = 2.85, hr = 0.33	af = 2.85, hr = 0.33
+—-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+—-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+—-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+—+	param	scale = 0.112, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.182, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.039, shape = 1.05
+—+	summary	mean = 8.8, median = 6.3	mean = 7.1, median = 5.1	mean = 5.4, median = 3.9	mean = 6.3, median = 4.5	mean = 4.5, median = 3.3	mean = 25, median = 18
+—+	effect	af = 1, hr = 1	af = 0.81, hr = 1.25	af = 0.61, hr = 1.67	af = 0.71, hr = 1.43	af = 0.52, hr = 2	af = 2.85, hr = 0.33
+–+-	param	scale = 0.112, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.182, shape = 1.05
+–+-	summary	mean = 8.8, median = 6.3	mean = 7.1, median = 5.1	mean = 25, median = 18	mean = 6.3, median = 4.5	mean = 4.5, median = 3.3	mean = 5.4, median = 3.9
+–+-	effect	af = 1, hr = 1	af = 0.81, hr = 1.25	af = 2.85, hr = 0.33	af = 0.71, hr = 1.43	af = 0.52, hr = 2	af = 0.61, hr = 1.67
+–++	param	scale = 0.112, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.058, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.039, shape = 1.05
+–++	summary	mean = 8.8, median = 6.3	mean = 7.1, median = 5.1	mean = 17, median = 12.2	mean = 6.3, median = 4.5	mean = 4.5, median = 3.3	mean = 25, median = 18
+–++	effect	af = 1, hr = 1	af = 0.81, hr = 1.25	af = 1.94, hr = 0.5	af = 0.71, hr = 1.43	af = 0.52, hr = 2	af = 2.85, hr = 0.33
+-+–	param	scale = 0.112, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.182, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.182, shape = 1.05
+-+–	summary	mean = 8.8, median = 6.3	mean = 7.1, median = 5.1	mean = 5.4, median = 3.9	mean = 6.3, median = 4.5	mean = 4.5, median = 3.3	mean = 5.4, median = 3.9
+-+–	effect	af = 1, hr = 1	af = 0.81, hr = 1.25	af = 0.61, hr = 1.67	af = 0.71, hr = 1.43	af = 0.52, hr = 2	af = 0.61, hr = 1.67
+-+-+	param	scale = 0.112, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.182, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.039, shape = 1.05
+-+-+	summary	mean = 8.8, median = 6.3	mean = 7.1, median = 5.1	mean = 5.4, median = 3.9	mean = 6.3, median = 4.5	mean = 4.5, median = 3.3	mean = 25, median = 18
+-+-+	effect	af = 1, hr = 1	af = 0.81, hr = 1.25	af = 0.61, hr = 1.67	af = 0.71, hr = 1.43	af = 0.52, hr = 2	af = 2.85, hr = 0.33
+-++-	param	scale = 0.112, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.182, shape = 1.05
+-++-	summary	mean = 8.8, median = 6.3	mean = 7.1, median = 5.1	mean = 25, median = 18	mean = 6.3, median = 4.5	mean = 4.5, median = 3.3	mean = 5.4, median = 3.9
+-++-	effect	af = 1, hr = 1	af = 0.81, hr = 1.25	af = 2.85, hr = 0.33	af = 0.71, hr = 1.43	af = 0.52, hr = 2	af = 0.61, hr = 1.67
+-+++	param	scale = 0.112, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.058, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.039, shape = 1.05
+-+++	summary	mean = 8.8, median = 6.3	mean = 7.1, median = 5.1	mean = 17, median = 12.2	mean = 6.3, median = 4.5	mean = 4.5, median = 3.3	mean = 25, median = 18
+-+++	effect	af = 1, hr = 1	af = 0.81, hr = 1.25	af = 1.94, hr = 0.5	af = 0.71, hr = 1.43	af = 0.52, hr = 2	af = 2.85, hr = 0.33
++—	param	scale = 0.112, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.182, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.182, shape = 1.05
++—	summary	mean = 8.8, median = 6.3	mean = 7.1, median = 5.1	mean = 5.4, median = 3.9	mean = 25, median = 18	mean = 25, median = 18	mean = 5.4, median = 3.9
++—	effect	af = 1, hr = 1	af = 0.81, hr = 1.25	af = 0.61, hr = 1.67	af = 2.85, hr = 0.33	af = 2.85, hr = 0.33	af = 0.61, hr = 1.67
++–+	param	scale = 0.112, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.182, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.039, shape = 1.05
++–+	summary	mean = 8.8, median = 6.3	mean = 7.1, median = 5.1	mean = 5.4, median = 3.9	mean = 25, median = 18	mean = 25, median = 18	mean = 25, median = 18
++–+	effect	af = 1, hr = 1	af = 0.81, hr = 1.25	af = 0.61, hr = 1.67	af = 2.85, hr = 0.33	af = 2.85, hr = 0.33	af = 2.85, hr = 0.33
++-+-	param	scale = 0.112, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.058, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.182, shape = 1.05
++-+-	summary	mean = 8.8, median = 6.3	mean = 7.1, median = 5.1	mean = 17, median = 12.2	mean = 25, median = 18	mean = 25, median = 18	mean = 5.4, median = 3.9
++-+-	effect	af = 1, hr = 1	af = 0.81, hr = 1.25	af = 1.94, hr = 0.5	af = 2.85, hr = 0.33	af = 2.85, hr = 0.33	af = 0.61, hr = 1.67
++-++	param	scale = 0.112, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.058, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.039, shape = 1.05
++-++	summary	mean = 8.8, median = 6.3	mean = 7.1, median = 5.1	mean = 17, median = 12.2	mean = 25, median = 18	mean = 25, median = 18	mean = 25, median = 18
++-++	effect	af = 1, hr = 1	af = 0.81, hr = 1.25	af = 1.94, hr = 0.5	af = 2.85, hr = 0.33	af = 2.85, hr = 0.33	af = 2.85, hr = 0.33
+++–	param	scale = 0.112, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.182, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.182, shape = 1.05
+++–	summary	mean = 8.8, median = 6.3	mean = 7.1, median = 5.1	mean = 5.4, median = 3.9	mean = 25, median = 18	mean = 25, median = 18	mean = 5.4, median = 3.9
+++–	effect	af = 1, hr = 1	af = 0.81, hr = 1.25	af = 0.61, hr = 1.67	af = 2.85, hr = 0.33	af = 2.85, hr = 0.33	af = 0.61, hr = 1.67
+++-+	param	scale = 0.112, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.182, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.039, shape = 1.05
+++-+	summary	mean = 8.8, median = 6.3	mean = 7.1, median = 5.1	mean = 5.4, median = 3.9	mean = 25, median = 18	mean = 25, median = 18	mean = 25, median = 18
+++-+	effect	af = 1, hr = 1	af = 0.81, hr = 1.25	af = 0.61, hr = 1.67	af = 2.85, hr = 0.33	af = 2.85, hr = 0.33	af = 2.85, hr = 0.33
++++-	param	scale = 0.112, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.064, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.182, shape = 1.05
++++-	summary	mean = 8.8, median = 6.3	mean = 7.1, median = 5.1	mean = 15.4, median = 11.1	mean = 25, median = 18	mean = 25, median = 18	mean = 5.4, median = 3.9
++++-	effect	af = 1, hr = 1	af = 0.81, hr = 1.25	af = 1.75, hr = 0.56	af = 2.85, hr = 0.33	af = 2.85, hr = 0.33	af = 0.61, hr = 1.67
+++++	param	scale = 0.112, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.064, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.039, shape = 1.05
+++++	summary	mean = 8.8, median = 6.3	mean = 7.1, median = 5.1	mean = 15.4, median = 11.1	mean = 25, median = 18	mean = 25, median = 18	mean = 25, median = 18
+++++	effect	af = 1, hr = 1	af = 0.81, hr = 1.25	af = 1.75, hr = 0.56	af = 2.85, hr = 0.33	af = 2.85, hr = 0.33	af = 2.85, hr = 0.33

Errors and power

graduation (counts and proportions):

TC1 TC2 TC3 TC4 TC5 all 20 2 2 0 12 AR- & TP53- 241 0 3 1 1 HRD+ 2 0 228 197 0 TP53+ 1 27 0 0 35 TEfus+ 0 91 0 0 1 PI3K+ 0 5 0 0 307

TC1 TC2 TC3 TC4 TC5 all 0.040 0.004 0.004 0.000 0.024 AR- & TP53- 0.482 0.000 0.006 0.002 0.002 HRD+ 0.004 0.000 0.456 0.394 0.000 TP53+ 0.002 0.054 0.000 0.000 0.070 TEfus+ 0.000 0.182 0.000 0.000 0.002 PI3K+ 0.000 0.010 0.000 0.000 0.614

futility (counts and proportions):

TC1 TC2 TC3 TC4 TC5 all 0 0 0 4 0 AR- & TP53- 1 60 19 34 3 HRD+ 2 19 0 0 10 TP53+ 122 0 87 126 0 TEfus+ 46 0 34 75 2 PI3K+ 13 3 75 104 0

TC1 TC2 TC3 TC4 TC5 all 0.000 0.000 0.000 0.008 0.000 AR- & TP53- 0.002 0.120 0.038 0.068 0.006 HRD+ 0.004 0.038 0.000 0.000 0.020 TP53+ 0.244 0.000 0.174 0.252 0.000 TEfus+ 0.092 0.000 0.068 0.150 0.004 PI3K+ 0.026 0.006 0.150 0.208 0.000

max sample size (counts and proportions):

TC1 TC2 TC3 TC4 TC5 all 0 0 0 0 0 AR- & TP53- 244 20 111 31 46 HRD+ 0 0 0 0 0 TP53+ 0 0 0 0 1 TEfus+ 0 1 0 0 0 PI3K+ 0 0 0 0 4

TC1 TC2 TC3 TC4 TC5 all 0.000 0.000 0.000 0.000 0.000 AR- & TP53- 0.488 0.040 0.222 0.062 0.092 HRD+ 0.000 0.000 0.000 0.000 0.000 TP53+ 0.000 0.000 0.000 0.000 0.002 TEfus+ 0.000 0.002 0.000 0.000 0.000 PI3K+ 0.000 0.000 0.000 0.000 0.008

Operating characteristics

char	overall	TC1	TC2	TC3	TC4	TC5
err_sign	0.1182365	0.0320641	0.0400802	0.0100200	0.0020040	0.0360721
err_type	0.2024048	0.0460922	0.0621242	0.0100200	0.0020040	0.0941884
pow_sign	0.9478958	0.4829659	0.1823647	0.4569138	0.3947896	0.6152305
pow_type	0.9619238	0.5110220	0.2224449	0.4669339	0.3967936	0.6513026

Median results at the end of the trial

By signature:

signature	var	Control	TC1	TC2	TC3	TC4	TC5
all	graduation	0	20	2	2	0	12
all	futility	0	0	0	0	4	0
all	max_n	0	0	0	0	0	0
all	n	426 (399, 453)	188 (81, 236)	160 (103, 210)	151 (97, 219)	114 (86, 168)	141 (85, 217)
all	n_unique	392 (369, 417)	176 (74, 221)	145 (93, 195)	138 (89, 204)	103 (77, 152)	128 (76, 201)
all	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
all	time_stop	NA (NA, NA)	5 (4, 8)	6 (4, 7)	6 (6, 7)	10 (8, 14)	6 (5, 10)
all	post_p	NA (NA, NA)	1 (0.57, 1)	0.88 (0.23, 1)	0.21 (0, 0.82)	0.21 (0, 0.78)	0.96 (0.25, 1)
all	rate	0.092 (0.085, 0.1)	0.065 (0.054, 0.087)	0.079 (0.067, 0.097)	0.101 (0.083, 0.12)	0.1 (0.083, 0.127)	0.073 (0.056, 0.097)
AR- & TP53-	graduation	0	241	0	3	1	1
AR- & TP53-	futility	0	1	60	19	34	3
AR- & TP53-	max_n	0	244	20	111	31	46
AR- & TP53-	n	260 (240, 285)	150 (26, 155)	57 (32, 100)	87 (47, 153)	59 (36, 103)	69 (34, 143)
AR- & TP53-	n_unique	242 (222, 264)	137 (25, 149)	51 (28, 92)	80 (42, 146)	53 (33, 96)	63 (31, 134)
AR- & TP53-	time_trial	36 (36, 36)	36 (6, 36)	36 (25, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
AR- & TP53-	time_stop	NA (NA, NA)	7 (5, 15)	18 (12, 32)	14 (11, 25)	15 (10, 20)	13 (10, 18)
AR- & TP53-	post_p	NA (NA, NA)	1 (0.99, 1)	0.1 (0, 0.53)	0.34 (0, 0.92)	0.46 (0, 0.93)	0.5 (0.01, 0.97)
AR- & TP53-	rate	0.085 (0.077, 0.094)	0.045 (0.036, 0.053)	0.112 (0.085, 0.149)	0.092 (0.065, 0.121)	0.085 (0.063, 0.131)	0.083 (0.06, 0.125)
HRD+	graduation	0	2	0	228	197	0
HRD+	futility	0	2	19	0	0	10
HRD+	max_n	0	0	0	0	0	0
HRD+	n	63 (52, 75)	16 (7, 28)	22 (14, 37)	37 (25, 54)	38 (25, 58)	18 (11, 28)
HRD+	n_unique	58 (46, 68)	14 (6, 25)	20 (12, 32)	34 (23, 50)	35 (22, 53)	16 (10, 25)
HRD+	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (19, 36)	36 (20, 36)	36 (36, 36)
HRD+	time_stop	NA (NA, NA)	31 (28, 33)	35 (26, 35)	24 (16, 32)	24 (17, 33)	32 (30, 35)
HRD+	post_p	NA (NA, NA)	0.48 (0.11, 0.87)	0.31 (0.06, 0.8)	1 (0.98, 1)	1 (0.96, 1)	0.17 (0.02, 0.58)
HRD+	rate	0.097 (0.078, 0.118)	0.09 (0.061, 0.151)	0.101 (0.07, 0.156)	0.038 (0.028, 0.05)	0.038 (0.028, 0.052)	0.124 (0.082, 0.188)
TP53+	graduation	0	1	27	0	0	35
TP53+	futility	0	122	0	87	126	0
TP53+	max_n	0	0	0	0	0	1
TP53+	n	137 (121, 153)	50 (28, 77)	81 (40, 109)	45 (28, 66)	37 (25, 58)	55 (29, 96)
TP53+	n_unique	125 (109, 139)	45 (25, 69)	74 (37, 99)	40 (26, 60)	34 (23, 52)	50 (26, 87)
TP53+	time_trial	36 (36, 36)	36 (22, 36)	36 (36, 36)	36 (26, 36)	36 (21, 36)	36 (36, 36)
TP53+	time_stop	NA (NA, NA)	24 (16, 32)	15 (11, 26)	24 (17, 33)	24 (16, 32)	14 (11, 23)
TP53+	post_p	NA (NA, NA)	0.09 (0.01, 0.45)	1 (0.89, 1)	0.15 (0.02, 0.56)	0.07 (0, 0.42)	1 (0.88, 1)
TP53+	rate	0.103 (0.09, 0.12)	0.133 (0.107, 0.166)	0.064 (0.051, 0.08)	0.127 (0.102, 0.158)	0.142 (0.11, 0.189)	0.057 (0.044, 0.078)
TEfus+	graduation	0	0	91	0	0	1
TEfus+	futility	0	46	0	34	75	2
TEfus+	max_n	0	0	1	0	0	0
TEfus+	n	129 (113, 146)	39 (25, 59)	94 (31, 118)	45 (32, 63)	39 (27, 54)	47 (28, 81)
TEfus+	n_unique	117 (102, 132)	35 (22, 53)	86 (29, 107)	40 (29, 59)	35 (25, 49)	43 (25, 74)
TEfus+	time_trial	36 (36, 36)	36 (36, 36)	36 (15, 36)	36 (36, 36)	36 (26, 36)	36 (36, 36)
TEfus+	time_stop	NA (NA, NA)	27 (18, 35)	15 (11, 27)	21 (15, 30)	22 (15, 31)	13 (12, 13)
TEfus+	post_p	NA (NA, NA)	0.08 (0, 0.41)	1 (0.97, 1)	0.18 (0.02, 0.63)	0.08 (0, 0.47)	0.88 (0.36, 1)
TEfus+	rate	0.082 (0.071, 0.094)	0.111 (0.089, 0.145)	0.046 (0.037, 0.057)	0.1 (0.076, 0.129)	0.112 (0.085, 0.157)	0.063 (0.048, 0.086)
PI3K+	graduation	0	0	5	0	0	307
PI3K+	futility	0	13	3	75	104	0
PI3K+	max_n	0	0	0	0	0	4
PI3K+	n	138 (120, 155)	45 (25, 73)	63 (34, 96)	43 (27, 72)	34 (25, 53)	62 (27, 124)
PI3K+	n_unique	126 (109, 141)	41 (21, 66)	56 (32, 87)	39 (24, 66)	31 (22, 48)	56 (25, 115)
PI3K+	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (26, 36)	36 (21, 36)	22 (11, 36)
PI3K+	time_stop	NA (NA, NA)	23 (15, 33)	14 (12, 30)	23 (17, 31)	22 (16, 33)	15 (10, 28)
PI3K+	post_p	NA (NA, NA)	0.47 (0.07, 0.9)	0.84 (0.36, 0.99)	0.11 (0.01, 0.53)	0.04 (0, 0.32)	1 (1, 1)
PI3K+	rate	0.097 (0.085, 0.112)	0.096 (0.074, 0.132)	0.079 (0.061, 0.102)	0.123 (0.096, 0.161)	0.144 (0.107, 0.194)	0.037 (0.029, 0.046)

By subgroup combinations:

subtype	var	Control	TC1	TC2	TC3	TC4	TC5
—–	graduation	0	254	2	5	1	13
—–	futility	0	1	60	19	38	3
—–	max_n	0	244	20	111	31	46
—–	n	159 (140, 175)	94 (20, 120)	15 (8, 52)	37 (10, 110)	13 (7, 54)	19 (8, 92)
—–	n_unique	149 (131, 165)	91 (20, 116)	14 (7, 51)	34 (9, 106)	11 (6, 52)	16 (7, 88)
—–	post_p	NA (NA, NA)	1 (0.99, 1)	0.02 (0, 0.07)	0.02 (0, 0.13)	0.01 (0, 0.06)	0.01 (0, 0.08)
—–	rate	0.086 (0.076, 0.098)	0.041 (0.033, 0.051)	0.195 (0.152, 0.308)	0.165 (0.13, 0.239)	0.235 (0.18, 0.383)	0.196 (0.153, 0.295)
—-+	graduation	0	251	7	5	1	301
—-+	futility	0	6	61	74	133	3
—-+	max_n	0	242	20	108	29	44
—-+	n	35 (27, 43)	8 (1, 22)	7 (3, 21)	8 (3, 23)	6 (3, 16)	16 (6, 37)
—-+	n_unique	32 (25, 40)	7 (1, 20)	6 (3, 19)	7 (3, 22)	5 (2, 14)	15 (6, 35)
—-+	post_p	NA (NA, NA)	0.87 (0.51, 0.99)	0.14 (0.03, 0.35)	0.18 (0.05, 0.43)	0.13 (0.03, 0.29)	0.99 (0.83, 1)
—-+	rate	0.092 (0.069, 0.126)	0.05 (0.024, 0.096)	0.198 (0.129, 0.402)	0.166 (0.11, 0.344)	0.246 (0.158, 0.498)	0.038 (0.024, 0.06)
—+-	graduation	0	235	84	5	1	13
—+-	futility	0	31	60	41	97	5
—+-	max_n	0	233	21	111	31	46
—+-	n	5 (2, 9)	1 (0, 4)	3 (1, 8)	2 (1, 5)	2 (0, 4)	2 (1, 5)
—+-	n_unique	5 (2, 8)	1 (0, 4)	3 (0, 7)	2 (0, 4)	2 (0, 4)	2 (1, 5)
—+-	post_p	NA (NA, NA)	0.53 (0.36, 0.81)	0.68 (0.43, 0.87)	0.37 (0.21, 0.55)	0.34 (0.21, 0.47)	0.35 (0.19, 0.52)
—+-	rate	0.063 (0.025, 0.132)	0.07 (0.02, 0.26)	0.045 (0, 0.137)	0.183 (0.081, 0.669)	0.255 (0.117, 0.821)	0.224 (0.085, 0.705)
—++	graduation	0	234	84	5	1	301
—++	futility	0	33	61	89	167	5
—++	max_n	0	232	21	108	29	44
—++	n	15 (10, 21)	3 (0, 9)	8 (2, 16)	4 (2, 9)	4 (2, 7)	6 (2, 15)
—++	n_unique	14 (9, 19)	3 (0, 8)	7 (2, 15)	4 (2, 9)	3 (1, 6)	5 (2, 14)
—++	post_p	NA (NA, NA)	0.49 (0.26, 0.82)	0.68 (0.34, 0.93)	0.22 (0.09, 0.4)	0.19 (0.06, 0.35)	0.8 (0.46, 0.96)
—++	rate	0.067 (0.043, 0.103)	0.073 (0.028, 0.187)	0.052 (0.023, 0.123)	0.182 (0.102, 0.473)	0.248 (0.135, 0.6)	0.037 (0.016, 0.084)
–+–	graduation	0	21	29	2	0	46
–+–	futility	0	122	0	87	130	0
–+–	max_n	0	0	0	0	0	1
–+–	n	26 (19, 34)	11 (4, 23)	11 (4, 23)	9 (4, 20)	10 (4, 24)	10 (3, 22)
–+–	n_unique	23 (17, 31)	10 (4, 21)	10 (4, 21)	9 (3, 19)	9 (3, 22)	8 (3, 20)
–+–	post_p	NA (NA, NA)	0.49 (0.18, 0.85)	0.46 (0.17, 0.82)	0.44 (0.16, 0.83)	0.48 (0.18, 0.85)	0.48 (0.18, 0.84)
–+–	rate	0.114 (0.086, 0.151)	0.121 (0.08, 0.214)	0.123 (0.083, 0.272)	0.125 (0.082, 0.277)	0.123 (0.081, 0.243)	0.123 (0.077, 0.238)
–+-+	graduation	0	21	31	2	0	325
–+-+	futility	0	128	3	126	173	0
–+-+	max_n	0	0	0	0	0	5
–+-+	n	29 (21, 36)	9 (3, 25)	6 (3, 19)	7 (3, 21)	5 (3, 13)	13 (4, 31)
–+-+	n_unique	26 (19, 33)	8 (3, 23)	6 (3, 18)	6 (3, 20)	5 (2, 11)	12 (4, 29)
–+-+	post_p	NA (NA, NA)	0.43 (0.16, 0.82)	0.26 (0.11, 0.57)	0.33 (0.12, 0.68)	0.23 (0.11, 0.45)	1 (0.95, 1)
–+-+	rate	0.144 (0.111, 0.19)	0.151 (0.099, 0.37)	0.201 (0.13, 0.432)	0.181 (0.117, 0.451)	0.241 (0.153, 0.538)	0.037 (0.022, 0.062)
–++-	graduation	0	21	111	2	0	46
–++-	futility	0	153	0	109	179	2
–++-	max_n	0	0	1	0	0	1
–++-	n	8 (4, 12)	3 (1, 6)	6 (2, 11)	3 (1, 5)	2 (1, 5)	3 (1, 5)
–++-	n_unique	7 (3, 11)	3 (1, 6)	5 (2, 10)	3 (1, 5)	2 (0, 4)	2 (1, 5)
–++-	post_p	NA (NA, NA)	0.39 (0.23, 0.62)	0.83 (0.55, 0.97)	0.38 (0.23, 0.58)	0.33 (0.18, 0.48)	0.35 (0.2, 0.51)
–++-	rate	0.086 (0.044, 0.164)	0.157 (0.078, 0.455)	0.041 (0.012, 0.094)	0.175 (0.079, 0.588)	0.264 (0.118, 0.883)	0.209 (0.105, 0.654)
–+++	graduation	0	21	110	2	0	325
–+++	futility	0	158	3	144	209	2
–+++	max_n	0	0	1	0	0	5
–+++	n	22 (15, 29)	5 (2, 13)	14 (3, 24)	5 (2, 12)	4 (2, 7)	9 (3, 23)
–+++	n_unique	20 (14, 27)	5 (2, 12)	13 (3, 22)	4 (2, 10)	3 (2, 6)	8 (3, 22)
–+++	post_p	NA (NA, NA)	0.26 (0.1, 0.5)	0.87 (0.51, 0.99)	0.22 (0.1, 0.45)	0.19 (0.08, 0.36)	0.95 (0.62, 1)
–+++	rate	0.091 (0.065, 0.129)	0.157 (0.094, 0.354)	0.051 (0.028, 0.09)	0.179 (0.107, 0.408)	0.244 (0.14, 0.643)	0.038 (0.018, 0.074)
-+—	graduation	0	255	2	191	191	13
-+—	futility	0	3	79	18	36	12
-+—	max_n	0	241	20	104	24	46
-+—	n	28 (21, 37)	4 (0, 12)	5 (3, 11)	16 (8, 28)	17 (8, 30)	5 (3, 13)
-+—	n_unique	25 (18, 34)	3 (0, 11)	5 (2, 10)	14 (8, 26)	16 (7, 28)	5 (2, 11)
-+—	post_p	NA (NA, NA)	0.69 (0.35, 0.93)	0.17 (0.06, 0.34)	0.97 (0.72, 1)	0.97 (0.74, 1)	0.17 (0.06, 0.34)
-+—	rate	0.096 (0.072, 0.138)	0.061 (0.029, 0.172)	0.202 (0.121, 0.437)	0.039 (0.024, 0.067)	0.038 (0.023, 0.064)	0.204 (0.125, 0.41)
-+–+	graduation	0	252	7	180	179	297
-+–+	futility	0	8	80	62	118	12
-+–+	max_n	0	239	20	102	22	44
-+–+	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-+–+	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-+–+	post_p	NA (NA, NA)	0.48 (0.48, 0.48)	0.48 (0.48, 0.49)	NA (NA, NA)	0.5 (0.5, 0.5)	NA (NA, NA)
-+–+	rate	0.191 (0, 0.698)	0.159 (0, 0.381)	0.283 (0.02, 0.817)	0.06 (0, 0.141)	0.063 (0, 0.287)	0.064 (0, 0.157)
-+-+-	graduation	0	236	84	190	185	13
-+-+-	futility	0	32	79	35	91	14
-+-+-	max_n	0	231	21	104	24	46
-+-+-	n	13 (8, 18)	2 (0, 6)	6 (2, 12)	7 (3, 13)	6 (2, 14)	4 (2, 7)
-+-+-	n_unique	12 (7, 17)	2 (0, 6)	5 (1, 11)	6 (2, 12)	6 (2, 13)	3 (1, 7)
-+-+-	post_p	NA (NA, NA)	0.47 (0.22, 0.73)	0.55 (0.26, 0.85)	0.76 (0.4, 0.95)	0.73 (0.36, 0.94)	0.21 (0.07, 0.38)
-+-+-	rate	0.074 (0.044, 0.122)	0.074 (0.032, 0.225)	0.059 (0.027, 0.174)	0.039 (0.016, 0.085)	0.042 (0.02, 0.102)	0.213 (0.109, 0.541)
-+-++	graduation	0	235	84	179	175	297
-+-++	futility	0	34	80	73	150	14
-+-++	max_n	0	230	21	102	22	44
-+-++	n	5 (2, 9)	1 (0, 3)	3 (0, 6)	3 (0, 6)	3 (1, 5)	1 (0, 5)
-+-++	n_unique	4 (2, 8)	1 (0, 3)	2 (0, 6)	2 (0, 6)	2 (0, 5)	1 (0, 4)
-+-++	post_p	NA (NA, NA)	0.44 (0.3, 0.63)	0.48 (0.31, 0.7)	0.54 (0.35, 0.76)	0.55 (0.36, 0.77)	0.55 (0.37, 0.74)
-+-++	rate	0.078 (0.028, 0.182)	0.087 (0.022, 0.299)	0.062 (0.013, 0.215)	0.043 (0.009, 0.123)	0.043 (0, 0.128)	0.04 (0, 0.152)
-++–	graduation	0	23	29	213	177	44
-++–	futility	0	124	19	71	108	10
-++–	max_n	0	0	0	0	0	1
-++–	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-++–	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-++–	post_p	NA (NA, NA)	0.47 (0.44, 0.53)	0.45 (0.43, 0.48)	0.47 (0.43, 0.52)	0.5 (0.5, 0.5)	0.49 (0.47, 0.52)
-++–	rate	0.129 (0, 0.997)	0.101 (0, 0.528)	0.475 (0.089, 3.106)	0.056 (0, 2.733)	0.035 (0, 0.494)	0.189 (0, 1.078)
-++-+	graduation	0	23	31	203	171	319
-++-+	futility	0	130	22	104	145	10
-++-+	max_n	0	0	0	0	0	5
-++-+	n	3 (1, 5)	1 (0, 3)	2 (0, 4)	2 (0, 4)	2 (0, 4)	1 (0, 3)
-++-+	n_unique	2 (1, 5)	1 (0, 3)	1 (0, 3)	1 (0, 4)	1 (0, 4)	1 (0, 3)
-++-+	post_p	NA (NA, NA)	0.45 (0.29, 0.58)	0.42 (0.27, 0.55)	0.6 (0.45, 0.79)	0.58 (0.43, 0.78)	0.58 (0.44, 0.79)
-++-+	rate	0.152 (0.053, 0.43)	0.164 (0.019, 0.67)	0.221 (0.083, 0.772)	0.039 (0, 0.174)	0.043 (0, 0.206)	0.039 (0, 0.178)
-+++-	graduation	0	23	111	212	172	44
-+++-	futility	0	154	19	90	153	12
-+++-	max_n	0	0	1	0	0	1
-+++-	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-+++-	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-+++-	post_p	NA (NA, NA)	0.53 (0.49, 0.56)	NA (NA, NA)	0.46 (0.41, 0.51)	0.49 (0.48, 0.53)	0.51 (0.49, 0.53)
-+++-	rate	0.138 (0, 0.548)	0.143 (0, 3.254)	0.081 (0, 0.239)	0.039 (0, 0.207)	0.077 (0, 0.324)	0.167 (0, 5.454)
-++++	graduation	0	23	110	202	167	319
-++++	futility	0	159	22	119	178	12
-++++	max_n	0	0	1	0	0	5
-++++	n	3 (1, 6)	1 (0, 3)	2 (0, 4)	2 (0, 4)	2 (0, 4)	1 (0, 3)
-++++	n_unique	3 (1, 6)	1 (0, 3)	1 (0, 4)	1 (0, 4)	1 (0, 4)	1 (0, 3)
-++++	post_p	NA (NA, NA)	0.42 (0.28, 0.55)	0.52 (0.36, 0.7)	0.56 (0.41, 0.75)	0.56 (0.41, 0.74)	0.54 (0.42, 0.71)
-++++	rate	0.104 (0.032, 0.315)	0.17 (0.042, 0.755)	0.064 (0, 0.265)	0.04 (0, 0.175)	0.04 (0, 0.171)	0.045 (0, 0.18)
+—-	graduation	0	20	2	2	0	12
+—-	futility	0	0	0	0	4	0
+—-	max_n	0	0	0	0	0	0
+—-	n	5 (2, 8)	2 (1, 5)	3 (1, 6)	2 (1, 5)	2 (1, 5)	2 (0, 5)
+—-	n_unique	4 (2, 7)	2 (0, 5)	3 (1, 6)	2 (0, 5)	2 (0, 5)	2 (0, 4)
+—-	post_p	NA (NA, NA)	0.46 (0.28, 0.7)	0.48 (0.29, 0.76)	0.46 (0.29, 0.72)	0.49 (0.3, 0.73)	0.47 (0.3, 0.74)
+—-	rate	0.111 (0.055, 0.22)	0.139 (0.053, 0.506)	0.123 (0.055, 0.413)	0.139 (0.041, 0.53)	0.129 (0.013, 0.475)	0.139 (0.04, 0.465)
+—+	graduation	0	20	7	2	0	316
+—+	futility	0	13	3	75	108	0
+—+	max_n	0	0	0	0	0	4
+—+	n	2 (0, 4)	1 (0, 3)	1 (0, 3)	1 (0, 3)	1 (0, 3)	1 (0, 3)
+—+	n_unique	1 (0, 4)	1 (0, 3)	1 (0, 3)	1 (0, 3)	1 (0, 3)	1 (0, 3)
+—+	post_p	NA (NA, NA)	0.5 (0.38, 0.68)	0.45 (0.33, 0.63)	0.45 (0.35, 0.61)	0.44 (0.32, 0.61)	0.64 (0.47, 0.82)
+—+	rate	0.182 (0.047, 0.707)	0.158 (0, 0.732)	0.237 (0.081, 0.886)	0.201 (0.063, 0.716)	0.284 (0.088, 1.119)	0.041 (0, 0.224)
+–+-	graduation	0	20	93	2	0	13
+–+-	futility	0	46	0	34	79	2
+–+-	max_n	0	0	1	0	0	0
+–+-	n	8 (4, 13)	3 (1, 7)	6 (2, 11)	3 (1, 6)	3 (1, 5)	3 (1, 5)
+–+-	n_unique	7 (4, 11)	3 (1, 6)	6 (2, 10)	3 (1, 5)	2 (1, 4)	2 (1, 5)
+–+-	post_p	NA (NA, NA)	0.38 (0.22, 0.62)	0.86 (0.52, 0.98)	0.36 (0.2, 0.57)	0.3 (0.17, 0.44)	0.34 (0.19, 0.53)
+–+-	rate	0.086 (0.04, 0.161)	0.159 (0.075, 0.407)	0.038 (0.015, 0.097)	0.182 (0.085, 0.634)	0.263 (0.134, 0.733)	0.214 (0.105, 0.585)
+–++	graduation	0	20	93	2	0	316
+–++	futility	0	55	3	98	150	2
+–++	max_n	0	0	1	0	0	4
+–++	n	4 (1, 7)	2 (0, 5)	2 (1, 6)	2 (0, 4)	2 (0, 4)	1 (0, 4)
+–++	n_unique	3 (1, 6)	2 (0, 4)	2 (0, 5)	2 (0, 4)	2 (0, 3)	1 (0, 4)
+–++	post_p	NA (NA, NA)	0.43 (0.29, 0.63)	0.61 (0.38, 0.83)	0.42 (0.26, 0.58)	0.37 (0.24, 0.49)	0.64 (0.42, 0.85)
+–++	rate	0.102 (0.035, 0.247)	0.151 (0.067, 0.585)	0.059 (0, 0.242)	0.188 (0.07, 0.701)	0.27 (0.099, 1.229)	0.046 (0, 0.18)
+-+–	graduation	0	21	29	2	0	46
+-+–	futility	0	122	0	87	130	0
+-+–	max_n	0	0	0	0	0	1
+-+–	n	1 (0, 3)	1 (0, 2)	1 (0, 3)	1 (0, 2)	1 (0, 2)	1 (0, 2)
+-+–	n_unique	1 (0, 3)	1 (0, 2)	1 (0, 3)	1 (0, 2)	1 (0, 2)	1 (0, 2)
+-+–	post_p	NA (NA, NA)	0.5 (0.37, 0.66)	0.47 (0.35, 0.63)	0.48 (0.38, 0.65)	0.45 (0.34, 0.62)	0.48 (0.38, 0.65)
+-+–	rate	0.161 (0.039, 0.746)	0.164 (0, 0.841)	0.207 (0.061, 1.002)	0.198 (0.047, 0.674)	0.262 (0.051, 1.355)	0.215 (0.041, 1.125)
+-+-+	graduation	0	21	31	2	0	325
+-+-+	futility	0	128	3	126	173	0
+-+-+	max_n	0	0	0	0	0	5
+-+-+	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+-+-+	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+-+-+	post_p	NA (NA, NA)	0.55 (0.55, 0.55)	0.45 (0.45, 0.45)	0.49 (0.46, 0.5)	0.5 (0.5, 0.5)	NA (NA, NA)
+-+-+	rate	0.133 (0, 1.503)	0.143 (0, 0.615)	0.203 (0, 0.853)	0.217 (0.097, 0.775)	0.182 (0.028, 1.645)	0 (0, 0.113)
+-++-	graduation	0	21	111	2	0	46
+-++-	futility	0	153	0	109	179	2
+-++-	max_n	0	0	1	0	0	1
+-++-	n	25 (19, 33)	6 (2, 14)	22 (7, 31)	5 (3, 12)	4 (2, 7)	5 (2, 9)
+-++-	n_unique	23 (16, 30)	5 (2, 12)	19 (7, 29)	5 (2, 11)	4 (2, 7)	4 (2, 8)
+-++-	post_p	NA (NA, NA)	0.24 (0.09, 0.52)	0.98 (0.84, 1)	0.21 (0.1, 0.43)	0.18 (0.08, 0.36)	0.2 (0.08, 0.4)
+-++-	rate	0.084 (0.06, 0.111)	0.162 (0.095, 0.361)	0.039 (0.024, 0.063)	0.185 (0.109, 0.419)	0.252 (0.148, 0.605)	0.207 (0.121, 0.504)
+-+++	graduation	0	21	110	2	0	325
+-+++	futility	0	158	3	144	209	2
+-+++	max_n	0	0	1	0	0	5
+-+++	n	18 (12, 25)	5 (2, 12)	12 (3, 21)	4 (2, 10)	4 (2, 7)	7 (2, 19)
+-+++	n_unique	16 (11, 23)	4 (1, 11)	11 (3, 20)	4 (2, 9)	3 (2, 6)	6 (2, 18)
+-+++	post_p	NA (NA, NA)	0.32 (0.14, 0.6)	0.8 (0.45, 0.98)	0.24 (0.1, 0.46)	0.2 (0.09, 0.36)	0.92 (0.62, 1)
+-+++	rate	0.095 (0.067, 0.135)	0.154 (0.083, 0.377)	0.059 (0.033, 0.11)	0.192 (0.11, 0.46)	0.246 (0.143, 0.557)	0.039 (0.018, 0.078)
++—	graduation	0	22	2	230	197	12
++—	futility	0	2	19	0	4	10
++—	max_n	0	0	0	0	0	0
++—	n	9 (5, 13)	3 (1, 6)	3 (1, 5)	5 (2, 10)	5 (2, 11)	3 (1, 5)
++—	n_unique	7 (4, 12)	3 (1, 6)	2 (1, 5)	5 (2, 10)	5 (2, 10)	3 (1, 5)
++—	post_p	NA (NA, NA)	0.39 (0.22, 0.66)	0.34 (0.17, 0.55)	0.85 (0.54, 0.98)	0.86 (0.56, 0.98)	0.34 (0.19, 0.52)
++—	rate	0.149 (0.094, 0.255)	0.161 (0.069, 0.483)	0.214 (0.098, 0.799)	0.039 (0.013, 0.098)	0.038 (0.015, 0.093)	0.217 (0.102, 0.575)
++–+	graduation	0	22	7	214	185	311
++–+	futility	0	15	22	63	95	10
++–+	max_n	0	0	0	0	0	4
++–+	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++–+	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++–+	post_p	NA (NA, NA)	0.48 (0.48, 0.48)	0.48 (0.46, 0.5)	0.6 (0.6, 0.6)	NA (NA, NA)	0.44 (0.44, 0.44)
++–+	rate	0.163 (0, 0.5)	0.163 (0, 0.796)	0.209 (0, 1.474)	0.165 (0.004, 0.252)	0.051 (0, 0.172)	0 (0, 0.212)
++-+-	graduation	0	22	93	229	191	13
++-+-	futility	0	47	19	28	74	12
++-+-	max_n	0	0	1	0	0	0
++-+-	n	1 (0, 2)	0 (0, 2)	0 (0, 2)	0 (0, 2)	0 (0, 2)	0 (0, 2)
++-+-	n_unique	1 (0, 2)	0 (0, 2)	0 (0, 2)	0 (0, 2)	0 (0, 2)	0 (0, 2)
++-+-	post_p	NA (NA, NA)	0.47 (0.39, 0.58)	0.54 (0.43, 0.61)	0.55 (0.44, 0.65)	0.54 (0.43, 0.65)	0.45 (0.37, 0.55)
++-+-	rate	0.113 (0, 0.488)	0.207 (0, 1.228)	0.061 (0, 0.353)	0.026 (0, 0.238)	0.05 (0, 0.244)	0.24 (0, 2.116)
++-++	graduation	0	22	93	213	181	311
++-++	futility	0	56	22	81	134	12
++-++	max_n	0	0	1	0	0	4
++-++	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++-++	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++-++	post_p	NA (NA, NA)	0.48 (0.45, 0.53)	NA (NA, NA)	0.52 (0.52, 0.52)	0.54 (0.54, 0.54)	0.53 (0.53, 0.53)
++-++	rate	0.19 (0.036, 1.21)	0.191 (0, 1.469)	0.094 (0, 0.951)	0.068 (0, 0.675)	0 (0, 0.083)	0 (0, 0.663)
+++–	graduation	0	23	29	213	177	44
+++–	futility	0	124	19	71	108	10
+++–	max_n	0	0	0	0	0	1
+++–	n	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)
+++–	n_unique	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)
+++–	post_p	NA (NA, NA)	0.49 (0.45, 0.57)	0.51 (0.41, 0.56)	0.55 (0.49, 0.6)	0.53 (0.48, 0.58)	0.48 (0.44, 0.56)
+++–	rate	0.23 (0, 2.174)	0.2 (0, 0.941)	0.24 (0, 1.065)	0.017 (0, 0.31)	0.035 (0, 0.214)	0.192 (0, 0.862)
+++-+	graduation	0	23	31	203	171	319
+++-+	futility	0	130	22	104	145	10
+++-+	max_n	0	0	0	0	0	5
+++-+	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+++-+	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+++-+	post_p	NA (NA, NA)	0.5 (0.46, 0.5)	0.52 (0.43, 0.56)	0.46 (0.44, 0.57)	0.42 (0.42, 0.42)	0.58 (0.58, 0.58)
+++-+	rate	0.134 (0, 0.307)	0.16 (0, 0.429)	0.143 (0, 0.569)	0.065 (0, 0.387)	0.069 (0, 0.542)	0 (0, 0.134)
++++-	graduation	0	23	111	212	172	44
++++-	futility	0	154	19	90	153	12
++++-	max_n	0	0	1	0	0	1
++++-	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++++-	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++++-	post_p	NA (NA, NA)	NA (NA, NA)	0.48 (0.48, 0.48)	0.51 (0.49, 0.52)	NA (NA, NA)	NA (NA, NA)
++++-	rate	0.124 (0, 1.351)	0.138 (0, 0.923)	0.112 (0, 1.572)	0.074 (0, 0.438)	0 (0, 0.204)	0.118 (0, 1.589)
+++++	graduation	0	23	110	202	167	319
+++++	futility	0	159	22	119	178	12
+++++	max_n	0	0	1	0	0	5
+++++	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+++++	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+++++	post_p	NA (NA, NA)	0.44 (0.39, 0.48)	NA (NA, NA)	0.45 (0.42, 0.58)	0.49 (0.44, 0.56)	0.53 (0.47, 0.59)
+++++	rate	0.109 (0, 0.448)	0.283 (0.078, 1.443)	0.142 (0, 0.973)	0.081 (0, 0.416)	0 (0, 0.16)	0.079 (0, 0.192)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates

Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:

signature	var	TC1	TC2	TC3	TC4	TC5
all	count	20	2	2		12
all	time_stop	5 (4, 8)	6 (4, 7)	6 (6, 7)		6 (5, 10)
all	n_trt	32 (27, 47)	26 (25, 27)	27 (27, 27)		30 (27, 58)
all	n_control	56 (42, 67)	60 (49, 72)	63 (60, 66)		62 (52, 89)
all	post_p	0.93 (0.9, 0.97)	0.89 (0.89, 0.9)	0.95 (0.94, 0.96)		0.97 (0.9, 0.99)
all	order	1 (1, 1.1)	1 (1, 1)	1.5 (1.1, 1.9)		1 (1, 2)
AR- & TP53-	count	241		3	1	1
AR- & TP53-	time_stop	7 (5, 15)		11 (10, 13)	10 (10, 10)	14 (14, 14)
AR- & TP53-	n_trt	32 (25, 75)		28 (27, 36)	28 (28, 28)	28 (28, 28)
AR- & TP53-	n_control	42 (29, 88)		68 (58, 76)	57 (57, 57)	81 (81, 81)
AR- & TP53-	post_p	0.95 (0.88, 1)		1 (0.97, 1)	0.98 (0.98, 0.98)	0.86 (0.86, 0.86)
AR- & TP53-	order	1 (1, 2)		1 (1, 1)	2 (2, 2)	2 (2, 2)
HRD+	count	2		228	197
HRD+	time_stop	28 (26, 30)		24 (16, 32)	24 (17, 33)
HRD+	n_trt	27 (26, 28)		28 (25, 43)	28 (25, 46)
HRD+	n_control	34 (33, 34)		35 (22, 57)	35 (22, 55)
HRD+	post_p	0.94 (0.94, 0.95)		0.99 (0.96, 1)	1 (0.96, 1)
HRD+	order	3 (2.2, 3.8)		2 (1, 4)	2 (1, 4)
TP53+	count	1	27			35
TP53+	time_stop	16 (16, 16)	15 (11, 26)			14 (11, 23)
TP53+	n_trt	25 (25, 25)	31 (25, 60)			28 (25, 40)
TP53+	n_control	50 (50, 50)	44 (33, 98)			42 (27, 70)
TP53+	post_p	0.9 (0.9, 0.9)	0.98 (0.94, 1)			0.99 (0.92, 1)
TP53+	order	2 (2, 2)	2 (1, 3.4)			2 (1, 3)
TEfus+	count		91			1
TEfus+	time_stop		15 (11, 27)			13 (13, 13)
TEfus+	n_trt		31 (25, 66)			26 (26, 26)
TEfus+	n_control		44 (29, 78)			33 (33, 33)
TEfus+	post_p		0.99 (0.94, 1)			0.94 (0.94, 0.94)
TEfus+	order		2 (1, 4)			3 (3, 3)
PI3K+	count		5			307
PI3K+	time_stop		13 (11, 17)			15 (10, 28)
PI3K+	n_trt		26 (25, 30)			38 (26, 78)
PI3K+	n_control		38 (31, 62)			46 (28, 95)
PI3K+	post_p		0.97 (0.89, 0.98)			1 (0.98, 1)
PI3K+	order		3 (2, 3.6)			2 (1, 3)

Futility:

signature	var	TC1	TC2	TC3	TC4	TC5
all	count				4
all	time_stop				10 (8, 14)
all	n_trt				30 (28, 47)
all	n_control				84 (72, 143)
all	post_p				0.03 (0.02, 0.07)
all	order				1 (1, 1)
AR- & TP53-	count	1	60	19	34	3
AR- & TP53-	time_stop	5 (5, 5)	18 (12, 32)	15 (11, 25)	16 (10, 20)	12 (10, 18)
AR- & TP53-	n_trt	28 (28, 28)	30 (25, 58)	35 (26, 66)	28 (25, 51)	26 (25, 29)
AR- & TP53-	n_control	26 (26, 26)	106 (66, 217)	92 (60, 169)	80 (51, 127)	68 (53, 110)
AR- & TP53-	post_p	0.29 (0.29, 0.29)	0.02 (0, 0.14)	0.07 (0.01, 0.22)	0.06 (0, 0.25)	0.14 (0.03, 0.25)
AR- & TP53-	order	1 (1, 1)	1 (1, 2)	1 (1, 2)	1 (1, 2)	1 (1, 1.8)
HRD+	count	2	19			10
HRD+	time_stop	32 (31, 34)	35 (26, 35)			32 (30, 35)
HRD+	n_trt	26 (25, 27)	26 (25, 34)			26 (25, 29)
HRD+	n_control	50 (40, 60)	58 (38, 71)			60 (52, 72)
HRD+	post_p	0.05 (0.04, 0.05)	0.07 (0.02, 0.2)			0.03 (0, 0.11)
HRD+	order	1.5 (1.1, 1.9)	2 (1, 3)			2 (1, 3.1)
TP53+	count	122		87	126
TP53+	time_stop	24 (16, 32)		24 (17, 33)	24 (16, 32)
TP53+	n_trt	34 (26, 52)		30 (25, 46)	27 (25, 36)
TP53+	n_control	80 (47, 118)		82 (50, 122)	80 (50, 117)
TP53+	post_p	0.04 (0.01, 0.14)		0.04 (0.01, 0.18)	0.02 (0, 0.16)
TP53+	order	2 (1, 3)		2 (1, 4)	2 (1, 3)
TEfus+	count	46		34	75	2
TEfus+	time_stop	27 (18, 35)		21 (15, 30)	22 (15, 31)	12 (12, 13)
TEfus+	n_trt	34 (26, 48)		30 (25, 39)	28 (25, 38)	26 (25, 26)
TEfus+	n_control	92 (55, 124)		61 (43, 103)	67 (44, 109)	32 (31, 33)
TEfus+	post_p	0.02 (0, 0.09)		0.03 (0, 0.09)	0.01 (0, 0.07)	0.11 (0.09, 0.13)
TEfus+	order	2 (1, 4)		1.5 (1, 3)	2 (1, 3)	1 (1, 1)
PI3K+	count	13	3	75	104
PI3K+	time_stop	23 (15, 33)	29 (18, 33)	23 (17, 31)	22 (16, 33)
PI3K+	n_trt	26 (25, 39)	25 (25, 27)	28 (25, 42)	28 (25, 37)
PI3K+	n_control	72 (46, 116)	113 (73, 119)	80 (49, 116)	71 (45, 118)
PI3K+	post_p	0.06 (0.02, 0.24)	0.08 (0.03, 0.19)	0.05 (0.01, 0.17)	0.02 (0, 0.14)
PI3K+	order	2 (1, 3.8)	2 (1.2, 2)	2 (1, 4)	2 (1, 4)

By subgroup combinations

Graduation:

signature	treatment	var	—–	—-+	—+-	—++	–+–	–+-+	–++-	–+++	-+—	-+–+	-+-+-	-+-++	-++–	-++-+	-+++-	-++++	+—-	+—+	+–+-	+–++	+-+–	+-+-+	+-++-	+-+++	++—	++–+	++-+-	++-++	+++–	+++-+	++++-	+++++
all	TC1	count	20	20	20	20	20	20	20	20	20	20	20	20	20	20	20	20	20	20	20	20	20	20	20	20	20	20	20	20	20	20	20	20
all	TC1	time	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)
all	TC1	n	18 (16, 31)	2 (1, 5)	0 (0, 1)	1 (0, 3)	3 (1, 5)	1 (0, 3)	0 (0, 1)	0 (0, 2)	0 (0, 2)	0 (0, 0)	0 (0, 1)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 0)	1 (0, 2)	1 (0, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC1	post_p	0.83 (0.68, 0.96)	0.55 (0.52, 0.59)	0.52 (0.5, 0.57)	0.53 (0.52, 0.55)	0.55 (0.51, 0.61)	0.55 (0.5, 0.61)	0.54 (0.54, 0.58)	0.56 (0.53, 0.59)	0.52 (0.51, 0.57)	NA (NA, NA)	0.51 (0.5, 0.52)	0.51 (0.5, 0.51)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.52 (0.5, 0.54)	NA (NA, NA)	0.54 (0.54, 0.54)	0.51 (0.51, 0.51)	0.54 (0.54, 0.55)	NA (NA, NA)	0.55 (0.53, 0.59)	0.55 (0.51, 0.6)	NA (NA, NA)	NA (NA, NA)	0.6 (0.6, 0.6)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC1	r_prob	0.41 (0.41, 0.41)	0.22 (0.22, 0.22)	0.37 (0.37, 0.37)	0.22 (0.22, 0.22)	0.31 (0.31, 0.31)	0.13 (0.13, 0.13)	0.18 (0.18, 0.18)	0.09 (0.09, 0.09)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.14 (0.14, 0.14)	0.18 (0.18, 0.18)	0.14 (0.14, 0.14)	0.12 (0.12, 0.12)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC1	rate	0.037 (0.008, 0.052)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0.077)	0 (0, 0.089)	0 (0, 1.264)	0 (0, 0.03)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0.377)	0 (0, 0.846)	0 (0, 0.482)	0 (0, 0)	0 (0, 0.12)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0.275 (0.275, 0.275)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC2	count	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2
all	TC2	time	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)
all	TC2	n	10 (10, 11)	0 (0, 0)	0 (0, 0)	1 (1, 1)	2 (2, 3)	0 (0, 1)	0 (0, 1)	1 (1, 1)	2 (0, 3)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	2 (2, 3)	1 (0, 2)	0 (0, 1)	0 (0, 0)	4 (3, 5)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC2	post_p	0.63 (0.6, 0.66)	NA (NA, NA)	NA (NA, NA)	0.52 (0.52, 0.52)	0.55 (0.52, 0.58)	0.53 (0.53, 0.53)	0.54 (0.54, 0.54)	0.54 (0.54, 0.54)	0.56 (0.56, 0.56)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.57 (0.52, 0.62)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.52 (0.52, 0.52)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC2	r_prob	0.18 (0.18, 0.18)	0.03 (0.03, 0.03)	0.25 (0.25, 0.25)	0.03 (0.03, 0.03)	0.17 (0.17, 0.17)	0.07 (0.07, 0.07)	0.41 (0.41, 0.41)	0.16 (0.16, 0.16)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.41 (0.41, 0.41)	0.29 (0.29, 0.29)	0.41 (0.41, 0.41)	0.29 (0.29, 0.29)	0.37 (0.37, 0.37)	0.21 (0.21, 0.21)	0.37 (0.37, 0.37)	0.21 (0.21, 0.21)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC2	rate	0.058 (0.035, 0.08)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0.099 (0.099, 0.099)	0 (0, 0)	NA (NA, NA)	0.043 (0.009, 0.078)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC3	count	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2
all	TC3	time	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)
all	TC3	n	6 (4, 7)	2 (1, 4)	0 (0, 0)	0 (0, 0)	2 (1, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	8 (8, 9)	0 (0, 0)	2 (2, 2)	1 (1, 1)	0 (0, 0)	0 (0, 1)	0 (0, 0)	1 (0, 2)	0 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 1)	1 (0, 2)	2 (1, 2)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC3	post_p	0.56 (0.52, 0.59)	0.5 (0.5, 0.51)	NA (NA, NA)	NA (NA, NA)	0.53 (0.52, 0.54)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.62 (0.58, 0.66)	NA (NA, NA)	NA (NA, NA)	0.5 (0.5, 0.5)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.61 (0.61, 0.61)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.53 (0.53, 0.53)	0.58 (0.58, 0.58)	0.51 (0.51, 0.51)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC3	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.07 (0.07, 0.07)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
all	TC3	rate	0.095 (0.087, 0.103)	0.054 (0.011, 0.098)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.016 (0.003, 0.029)	NA (NA, NA)	0.124 (0.025, 0.223)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	11.962 (11.962, 11.962)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0.064 (0.013, 0.115)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC5	count	12	12	12	12	12	12	12	12	12	12	12	12	12	12	12	12	12	12	12	12	12	12	12	12	12	12	12	12	12	12	12	12
all	TC5	time	6 (5, 10)	6 (5, 10)	6 (5, 10)	6 (5, 10)	6 (5, 10)	6 (5, 10)	6 (5, 10)	6 (5, 10)	6 (5, 10)	6 (5, 10)	6 (5, 10)	6 (5, 10)	6 (5, 10)	6 (5, 10)	6 (5, 10)	6 (5, 10)	6 (5, 10)	6 (5, 10)	6 (5, 10)	6 (5, 10)	6 (5, 10)	6 (5, 10)	6 (5, 10)	6 (5, 10)	6 (5, 10)	6 (5, 10)	6 (5, 10)	6 (5, 10)	6 (5, 10)	6 (5, 10)	6 (5, 10)	6 (5, 10)
all	TC5	n	4 (1, 11)	6 (4, 11)	0 (0, 1)	2 (0, 4)	2 (0, 3)	6 (1, 9)	0 (0, 0)	4 (3, 8)	0 (0, 4)	0 (0, 0)	0 (0, 1)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 0)	0 (0, 0)	1 (0, 2)	4 (2, 5)	0 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC5	post_p	0.55 (0.52, 0.61)	0.6 (0.51, 0.84)	0.52 (0.52, 0.52)	0.54 (0.52, 0.58)	0.54 (0.51, 0.74)	0.72 (0.51, 0.79)	NA (NA, NA)	0.59 (0.54, 0.72)	0.52 (0.51, 0.58)	NA (NA, NA)	0.54 (0.52, 0.55)	0.52 (0.51, 0.53)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.54 (0.51, 0.54)	0.55 (0.54, 0.57)	0.56 (0.53, 0.6)	0.54 (0.54, 0.55)	0.55 (0.55, 0.56)	NA (NA, NA)	NA (NA, NA)	0.54 (0.51, 0.63)	0.57 (0.52, 0.65)	0.52 (0.52, 0.52)	NA (NA, NA)	0.52 (0.52, 0.52)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC5	r_prob	0 (0, 0)	0.38 (0.38, 0.38)	0 (0, 0)	0.38 (0.38, 0.38)	0.07 (0.07, 0.07)	0.33 (0.33, 0.33)	0 (0, 0)	0.38 (0.38, 0.38)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC5	rate	0.024 (0, 0.11)	0.045 (0, 0.082)	0 (0, 0)	0 (0, 0.014)	0 (0, 0.12)	0 (0, 0.068)	NA (NA, NA)	0 (0, 0.035)	0 (0, 0.089)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0 (0, 0.067)	0 (0, 0.307)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)
AR- & TP53-	TC1	count	241	241	241	241					241	241	241	241
AR- & TP53-	TC1	time	7 (5, 15)	7 (5, 15)	7 (5, 15)	7 (5, 15)					7 (5, 15)	7 (5, 15)	7 (5, 15)	7 (5, 15)
AR- & TP53-	TC1	n	25 (20, 56)	3 (1, 9)	1 (0, 3)	1 (0, 4)					1 (0, 5)	0 (0, 0)	0 (0, 3)	0 (0, 1)
AR- & TP53-	TC1	post_p	0.95 (0.83, 1)	0.58 (0.52, 0.8)	0.54 (0.51, 0.61)	0.53 (0.51, 0.65)					0.54 (0.51, 0.72)	NA (NA, NA)	0.53 (0.51, 0.61)	0.54 (0.51, 0.57)
AR- & TP53-	TC1	r_prob	0.41 (0.41, 0.41)	0.22 (0.22, 0.22)	0.37 (0.37, 0.37)	0.22 (0.22, 0.22)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC1	rate	0.036 (0.013, 0.056)	0 (0, 0.086)	0 (0, 0.125)	0 (0, 0.097)					0 (0, 0.059)	0 (0, 0.461)	0 (0, 0.069)	0 (0, 0.072)
AR- & TP53-	TC3	count	3	3	3	3					3	3	3	3
AR- & TP53-	TC3	time	11 (10, 13)	11 (10, 13)	11 (10, 13)	11 (10, 13)					11 (10, 13)	11 (10, 13)	11 (10, 13)	11 (10, 13)
AR- & TP53-	TC3	n	12 (9, 15)	3 (2, 4)	0 (0, 0)	1 (0, 3)					12 (7, 12)	0 (0, 0)	2 (2, 5)	2 (0, 2)
AR- & TP53-	TC3	post_p	0.83 (0.73, 0.86)	0.58 (0.54, 0.69)	NA (NA, NA)	0.55 (0.54, 0.56)					0.76 (0.74, 0.88)	NA (NA, NA)	0.78 (0.62, 0.94)	0.54 (0.54, 0.54)
AR- & TP53-	TC3	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
AR- & TP53-	TC3	rate	0.029 (0.006, 0.053)	0.065 (0.013, 0.116)	NA (NA, NA)	0.048 (0.01, 0.087)					0.011 (0.002, 0.011)	NA (NA, NA)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC4	count	1	1	1	1					1	1	1	1
AR- & TP53-	TC4	time	10 (10, 10)	10 (10, 10)	10 (10, 10)	10 (10, 10)					10 (10, 10)	10 (10, 10)	10 (10, 10)	10 (10, 10)
AR- & TP53-	TC4	n	18 (18, 18)	2 (2, 2)	0 (0, 0)	1 (1, 1)					2 (2, 2)	0 (0, 0)	4 (4, 4)	1 (1, 1)
AR- & TP53-	TC4	post_p	0.85 (0.85, 0.85)	0.58 (0.58, 0.58)	NA (NA, NA)	0.54 (0.54, 0.54)					0.68 (0.68, 0.68)	NA (NA, NA)	0.62 (0.62, 0.62)	0.57 (0.57, 0.57)
AR- & TP53-	TC4	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
AR- & TP53-	TC4	rate	0.054 (0.054, 0.054)	0 (0, 0)	NA (NA, NA)	0 (0, 0)					0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC5	count	1	1	1	1					1	1	1	1
AR- & TP53-	TC5	time	14 (14, 14)	14 (14, 14)	14 (14, 14)	14 (14, 14)					14 (14, 14)	14 (14, 14)	14 (14, 14)	14 (14, 14)
AR- & TP53-	TC5	n	10 (10, 10)	8 (8, 8)	1 (1, 1)	5 (5, 5)					4 (4, 4)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC5	post_p	0.7 (0.7, 0.7)	0.72 (0.72, 0.72)	0.61 (0.61, 0.61)	0.54 (0.54, 0.54)					0.54 (0.54, 0.54)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
AR- & TP53-	TC5	r_prob	0 (0, 0)	0.38 (0.38, 0.38)	0 (0, 0)	0.38 (0.38, 0.38)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC5	rate	0.055 (0.055, 0.055)	0.048 (0.048, 0.048)	0 (0, 0)	0.082 (0.082, 0.082)					0.062 (0.062, 0.062)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC1	count									2	2	2	2	2	2	2	2									2	2	2	2	2	2	2	2
HRD+	TC1	time									28 (26, 30)	28 (26, 30)	28 (26, 30)	28 (26, 30)	28 (26, 30)	28 (26, 30)	28 (26, 30)	28 (26, 30)									28 (26, 30)	28 (26, 30)	28 (26, 30)	28 (26, 30)	28 (26, 30)	28 (26, 30)	28 (26, 30)	28 (26, 30)
HRD+	TC1	n									12 (10, 14)	0 (0, 0)	4 (3, 5)	3 (2, 4)	0 (0, 0)	2 (2, 2)	0 (0, 0)	1 (0, 2)									3 (2, 4)	0 (0, 0)	2 (1, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 1)	0 (0, 0)
HRD+	TC1	post_p									0.81 (0.74, 0.89)	NA (NA, NA)	0.62 (0.57, 0.67)	0.53 (0.51, 0.56)	NA (NA, NA)	0.64 (0.64, 0.64)	NA (NA, NA)	0.52 (0.52, 0.52)									0.57 (0.56, 0.57)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC1	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC1	rate									0.051 (0.043, 0.058)	NA (NA, NA)	0.019 (0.004, 0.035)	0.04 (0.034, 0.046)	NA (NA, NA)	0.289 (0.058, 0.521)	NA (NA, NA)	0 (0, 0)									0.054 (0.033, 0.075)	NA (NA, NA)	0.92 (0.317, 1.524)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)
HRD+	TC3	count									228	228	228	228	228	228	228	228									228	228	228	228	228	228	228	228
HRD+	TC3	time									24 (16, 32)	24 (16, 32)	24 (16, 32)	24 (16, 32)	24 (16, 32)	24 (16, 32)	24 (16, 32)	24 (16, 32)									24 (16, 32)	24 (16, 32)	24 (16, 32)	24 (16, 32)	24 (16, 32)	24 (16, 32)	24 (16, 32)	24 (16, 32)
HRD+	TC3	n									14 (9, 22)	0 (0, 0)	6 (3, 10)	2 (0, 5)	0 (0, 0)	1 (0, 3)	0 (0, 0)	1 (0, 3)									4 (2, 8)	0 (0, 0)	0 (0, 2)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC3	post_p									0.9 (0.74, 0.99)	NA (NA, NA)	0.72 (0.54, 0.87)	0.55 (0.51, 0.72)	NA (NA, NA)	0.57 (0.52, 0.75)	0.56 (0.56, 0.56)	0.56 (0.51, 0.67)									0.71 (0.54, 0.93)	NA (NA, NA)	0.57 (0.53, 0.67)	NA (NA, NA)	0.55 (0.53, 0.58)	0.51 (0.51, 0.51)	NA (NA, NA)	0.56 (0.56, 0.56)
HRD+	TC3	r_prob									0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)									0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
HRD+	TC3	rate									0.035 (0.015, 0.059)	0 (0, 0)	0.03 (0, 0.062)	0.024 (0, 0.082)	0 (0, 4.128)	0.03 (0, 0.106)	0 (0, 1.046)	0 (0, 0.081)									0.031 (0, 0.082)	0.138 (0, 2.76)	0 (0, 0.189)	0 (0, 0.013)	0 (0, 0.139)	0 (0, 0.415)	0.053 (0, 0.844)	0 (0, 0.182)
HRD+	TC4	count									197	197	197	197	197	197	197	197									197	197	197	197	197	197	197	197
HRD+	TC4	time									24 (17, 33)	24 (17, 33)	24 (17, 33)	24 (17, 33)	24 (17, 33)	24 (17, 33)	24 (17, 33)	24 (17, 33)									24 (17, 33)	24 (17, 33)	24 (17, 33)	24 (17, 33)	24 (17, 33)	24 (17, 33)	24 (17, 33)	24 (17, 33)
HRD+	TC4	n									14 (9, 21)	0 (0, 0)	5 (3, 12)	2 (0, 4)	0 (0, 0)	1 (0, 4)	0 (0, 0)	1 (0, 3)									4 (2, 8)	0 (0, 0)	0 (0, 2)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC4	post_p									0.9 (0.75, 0.99)	0.5 (0.5, 0.5)	0.72 (0.52, 0.89)	0.57 (0.51, 0.7)	0.5 (0.5, 0.5)	0.57 (0.51, 0.7)	NA (NA, NA)	0.55 (0.51, 0.68)									0.73 (0.56, 0.91)	NA (NA, NA)	0.55 (0.52, 0.6)	0.57 (0.57, 0.57)	0.53 (0.52, 0.57)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC4	r_prob									0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)									0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
HRD+	TC4	rate									0.033 (0.015, 0.057)	0.09 (0, 0.687)	0.033 (0, 0.065)	0.022 (0, 0.075)	0 (0, 0.348)	0.013 (0, 0.105)	0.122 (0.122, 0.122)	0 (0, 0.072)									0.031 (0, 0.082)	0.017 (0, 0.185)	0 (0, 0.187)	0 (0, 0)	0 (0, 0.204)	0.542 (0.2, 1.458)	0 (0, 1.353)	0.018 (0, 0.047)
TP53+	TC1	count					1	1	1	1					1	1	1	1					1	1	1	1					1	1	1	1
TP53+	TC1	time					16 (16, 16)	16 (16, 16)	16 (16, 16)	16 (16, 16)					16 (16, 16)	16 (16, 16)	16 (16, 16)	16 (16, 16)					16 (16, 16)	16 (16, 16)	16 (16, 16)	16 (16, 16)					16 (16, 16)	16 (16, 16)	16 (16, 16)	16 (16, 16)
TP53+	TC1	n					6 (6, 6)	9 (9, 9)	0 (0, 0)	5 (5, 5)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	2 (2, 2)	3 (3, 3)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC1	post_p					0.7 (0.7, 0.7)	0.84 (0.84, 0.84)	NA (NA, NA)	0.54 (0.54, 0.54)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)					NA (NA, NA)	NA (NA, NA)	0.6 (0.6, 0.6)	0.64 (0.64, 0.64)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC1	r_prob					0.31 (0.31, 0.31)	0.13 (0.13, 0.13)	0.18 (0.18, 0.18)	0.09 (0.09, 0.09)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.12 (0.12, 0.12)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.07 (0.07, 0.07)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC1	rate					0.042 (0.042, 0.042)	0.094 (0.094, 0.094)	NA (NA, NA)	0.144 (0.144, 0.144)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)					NA (NA, NA)	NA (NA, NA)	0.102 (0.102, 0.102)	0 (0, 0)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC2	count					27	27	27	27					27	27	27	27					27	27	27	27					27	27	27	27
TP53+	TC2	time					15 (11, 26)	15 (11, 26)	15 (11, 26)	15 (11, 26)					15 (11, 26)	15 (11, 26)	15 (11, 26)	15 (11, 26)					15 (11, 26)	15 (11, 26)	15 (11, 26)	15 (11, 26)					15 (11, 26)	15 (11, 26)	15 (11, 26)	15 (11, 26)
TP53+	TC2	n					7 (4, 14)	4 (2, 6)	2 (1, 6)	4 (2, 10)					0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 2)					0 (0, 2)	0 (0, 0)	9 (4, 18)	4 (2, 10)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC2	post_p					0.72 (0.53, 0.91)	0.54 (0.5, 0.73)	0.62 (0.55, 0.74)	0.66 (0.52, 0.85)					NA (NA, NA)	0.53 (0.51, 0.55)	NA (NA, NA)	0.57 (0.5, 0.62)					0.58 (0.57, 0.62)	NA (NA, NA)	0.83 (0.62, 0.96)	0.73 (0.54, 0.9)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC2	r_prob					0.17 (0.17, 0.17)	0.07 (0.07, 0.07)	0.41 (0.41, 0.41)	0.16 (0.16, 0.16)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.37 (0.37, 0.37)	0.21 (0.21, 0.21)	0.37 (0.37, 0.37)	0.21 (0.21, 0.21)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC2	rate					0.069 (0.033, 0.099)	0.118 (0.054, 0.17)	0.028 (0, 0.107)	0.041 (0, 0.108)					0.593 (0.593, 0.593)	0 (0, 0.734)	NA (NA, NA)	0 (0, 0.093)					0.136 (0, 0.841)	1.029 (0.383, 1.674)	0.035 (0, 0.062)	0.05 (0, 0.075)					0.795 (0.282, 1.059)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC5	count					35	35	35	35					35	35	35	35					35	35	35	35					35	35	35	35
TP53+	TC5	time					14 (11, 23)	14 (11, 23)	14 (11, 23)	14 (11, 23)					14 (11, 23)	14 (11, 23)	14 (11, 23)	14 (11, 23)					14 (11, 23)	14 (11, 23)	14 (11, 23)	14 (11, 23)					14 (11, 23)	14 (11, 23)	14 (11, 23)	14 (11, 23)
TP53+	TC5	n					5 (2, 8)	10 (4, 13)	1 (0, 3)	5 (2, 14)					0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 2)					0 (0, 1)	0 (0, 0)	3 (1, 5)	4 (2, 8)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC5	post_p					0.72 (0.52, 0.9)	0.91 (0.75, 0.99)	0.56 (0.52, 0.62)	0.78 (0.6, 0.95)					NA (NA, NA)	0.56 (0.53, 0.57)	NA (NA, NA)	0.57 (0.54, 0.6)					0.55 (0.52, 0.56)	NA (NA, NA)	0.56 (0.52, 0.68)	0.71 (0.52, 0.88)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC5	r_prob					0.07 (0.07, 0.07)	0.33 (0.33, 0.33)	0 (0, 0)	0.38 (0.38, 0.38)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC5	rate					0.051 (0, 0.121)	0.04 (0.004, 0.081)	0 (0, 0.156)	0.034 (0, 0.052)					0.335 (0.335, 0.335)	0 (0, 0.02)	NA (NA, NA)	0 (0, 0.008)					0.145 (0, 0.567)	0.117 (0.117, 0.117)	0.066 (0, 0.148)	0.047 (0, 0.091)					0.194 (0.039, 0.205)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)
TEfus+	TC2	count			91	91			91	91			91	91			91	91			91	91			91	91			91	91			91	91
TEfus+	TC2	time			15 (11, 27)	15 (11, 27)			15 (11, 27)	15 (11, 27)			15 (11, 27)	15 (11, 27)			15 (11, 27)	15 (11, 27)			15 (11, 27)	15 (11, 27)			15 (11, 27)	15 (11, 27)			15 (11, 27)	15 (11, 27)			15 (11, 27)	15 (11, 27)
TEfus+	TC2	n			2 (0, 5)	3 (1, 8)			3 (1, 6)	4 (2, 12)			3 (0, 6)	1 (0, 3)			0 (0, 0)	1 (0, 2)			3 (1, 6)	1 (0, 3)			8 (4, 16)	4 (2, 11)			0 (0, 1)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC2	post_p			0.59 (0.52, 0.74)	0.6 (0.53, 0.8)			0.66 (0.54, 0.8)	0.66 (0.53, 0.87)			0.57 (0.51, 0.73)	0.55 (0.51, 0.62)			NA (NA, NA)	0.53 (0.51, 0.61)			0.62 (0.52, 0.89)	0.57 (0.51, 0.73)			0.83 (0.62, 0.98)	0.68 (0.54, 0.87)			0.54 (0.51, 0.6)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC2	r_prob			0.25 (0.25, 0.25)	0.03 (0.03, 0.03)			0.41 (0.41, 0.41)	0.16 (0.16, 0.16)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.41 (0.41, 0.41)	0.29 (0.29, 0.29)			0.37 (0.37, 0.37)	0.21 (0.21, 0.21)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC2	rate			0 (0, 0.066)	0 (0, 0.072)			0.022 (0, 0.093)	0.036 (0, 0.077)			0.013 (0, 0.079)	0 (0, 0.078)			0.064 (0.013, 0.115)	0 (0, 0.158)			0.02 (0, 0.087)	0 (0, 0.098)			0.034 (0, 0.064)	0.039 (0, 0.094)			0 (0, 0.456)	0.032 (0.032, 0.032)			0.105 (0.056, 0.154)	0.18 (0.18, 0.18)
TEfus+	TC5	count			1	1			1	1			1	1			1	1			1	1			1	1			1	1			1	1
TEfus+	TC5	time			13 (13, 13)	13 (13, 13)			13 (13, 13)	13 (13, 13)			13 (13, 13)	13 (13, 13)			13 (13, 13)	13 (13, 13)			13 (13, 13)	13 (13, 13)			13 (13, 13)	13 (13, 13)			13 (13, 13)	13 (13, 13)			13 (13, 13)	13 (13, 13)
TEfus+	TC5	n			1 (1, 1)	5 (5, 5)			0 (0, 0)	11 (11, 11)			5 (5, 5)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			1 (1, 1)	3 (3, 3)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC5	post_p			0.57 (0.57, 0.57)	0.51 (0.51, 0.51)			NA (NA, NA)	0.88 (0.88, 0.88)			0.5 (0.5, 0.5)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)			0.59 (0.59, 0.59)	0.74 (0.74, 0.74)			NA (NA, NA)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC5	r_prob			0 (0, 0)	0.38 (0.38, 0.38)			0 (0, 0)	0.38 (0.38, 0.38)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0.29 (0.29, 0.29)			0 (0, 0)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC5	rate			0 (0, 0)	0.071 (0.071, 0.071)			NA (NA, NA)	0.026 (0.026, 0.026)			0.08 (0.08, 0.08)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)			0 (0, 0)	0 (0, 0)			NA (NA, NA)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
PI3K+	TC2	count		5		5		5		5		5		5		5		5		5		5		5		5		5		5		5		5
PI3K+	TC2	time		13 (11, 17)		13 (11, 17)		13 (11, 17)		13 (11, 17)		13 (11, 17)		13 (11, 17)		13 (11, 17)		13 (11, 17)		13 (11, 17)		13 (11, 17)		13 (11, 17)		13 (11, 17)		13 (11, 17)		13 (11, 17)		13 (11, 17)		13 (11, 17)
PI3K+	TC2	n		4 (3, 5)		3 (1, 5)		5 (3, 6)		4 (4, 6)		0 (0, 1)		1 (0, 2)		0 (0, 1)		2 (0, 2)		1 (0, 2)		1 (0, 3)		0 (0, 0)		4 (3, 10)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC2	post_p		0.55 (0.52, 0.85)		0.6 (0.55, 0.73)		0.55 (0.52, 0.7)		0.7 (0.52, 0.8)		NA (NA, NA)		0.58 (0.52, 0.63)		0.51 (0.51, 0.51)		0.51 (0.5, 0.64)		0.52 (0.52, 0.52)		0.51 (0.51, 0.51)		NA (NA, NA)		0.68 (0.59, 0.83)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC2	r_prob		0.03 (0.03, 0.03)		0.03 (0.03, 0.03)		0.07 (0.07, 0.07)		0.16 (0.16, 0.16)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0.21 (0.21, 0.21)		0.21 (0.21, 0.21)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC2	rate		0.057 (0, 0.068)		0 (0, 0.061)		0.115 (0.042, 0.142)		0.03 (0.007, 0.113)		0.475 (0.475, 0.475)		0 (0, 0.203)		0 (0, 0)		0 (0, 0.065)		0.239 (0.048, 0.362)		0 (0, 0.069)		NA (NA, NA)		0.032 (0.007, 0.043)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC5	count		307		307		307		307		307		307		307		307		307		307		307		307		307		307		307		307
PI3K+	TC5	time		15 (10, 28)		15 (10, 28)		15 (10, 28)		15 (10, 28)		15 (10, 28)		15 (10, 28)		15 (10, 28)		15 (10, 28)		15 (10, 28)		15 (10, 28)		15 (10, 28)		15 (10, 28)		15 (10, 28)		15 (10, 28)		15 (10, 28)		15 (10, 28)
PI3K+	TC5	n		11 (6, 24)		5 (2, 11)		9 (4, 19)		6 (3, 15)		0 (0, 0)		1 (0, 3)		0 (0, 2)		0 (0, 2)		0 (0, 2)		1 (0, 3)		0 (0, 0)		5 (2, 11)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC5	post_p		0.85 (0.71, 0.99)		0.64 (0.52, 0.85)		0.9 (0.69, 1)		0.75 (0.53, 0.96)		NA (NA, NA)		0.54 (0.51, 0.66)		0.57 (0.52, 0.67)		0.54 (0.51, 0.61)		0.58 (0.52, 0.7)		0.56 (0.51, 0.68)		NA (NA, NA)		0.73 (0.54, 0.95)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC5	r_prob		0.38 (0.38, 0.38)		0.38 (0.38, 0.38)		0.33 (0.33, 0.33)		0.38 (0.38, 0.38)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC5	rate		0.033 (0, 0.06)		0.027 (0, 0.075)		0.032 (0, 0.082)		0.032 (0, 0.07)		0 (0, 0.081)		0 (0, 0.072)		0 (0, 0.116)		0 (0, 0.097)		0 (0, 0.153)		0 (0, 0.133)		0 (0, 0.428)		0.028 (0, 0.075)		0 (0, 0)		0 (0, 0)		0 (0, 0.095)		0 (0, 0)

Futility:

signature	treatment	var	—–	—-+	—+-	—++	–+–	–+-+	–++-	–+++	-+—	-+–+	-+-+-	-+-++	-++–	-++-+	-+++-	-++++	+—-	+—+	+–+-	+–++	+-+–	+-+-+	+-++-	+-+++	++—	++–+	++-+-	++-++	+++–	+++-+	++++-	+++++
all	TC4	count	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4
all	TC4	time	10 (8, 14)	10 (8, 14)	10 (8, 14)	10 (8, 14)	10 (8, 14)	10 (8, 14)	10 (8, 14)	10 (8, 14)	10 (8, 14)	10 (8, 14)	10 (8, 14)	10 (8, 14)	10 (8, 14)	10 (8, 14)	10 (8, 14)	10 (8, 14)	10 (8, 14)	10 (8, 14)	10 (8, 14)	10 (8, 14)	10 (8, 14)	10 (8, 14)	10 (8, 14)	10 (8, 14)	10 (8, 14)	10 (8, 14)	10 (8, 14)	10 (8, 14)	10 (8, 14)	10 (8, 14)	10 (8, 14)	10 (8, 14)
all	TC4	n	6 (4, 9)	4 (2, 5)	0 (0, 2)	1 (0, 1)	3 (2, 7)	1 (1, 2)	0 (0, 1)	2 (0, 3)	2 (1, 4)	0 (0, 0)	4 (2, 4)	0 (0, 2)	0 (0, 0)	0 (0, 1)	0 (0, 0)	1 (0, 2)	0 (0, 2)	0 (0, 1)	0 (0, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	2 (1, 3)	3 (2, 4)	1 (0, 5)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC4	post_p	0.29 (0.1, 0.38)	0.42 (0.31, 0.48)	0.41 (0.38, 0.44)	0.4 (0.38, 0.45)	0.36 (0.13, 0.45)	0.39 (0.35, 0.42)	0.47 (0.47, 0.47)	0.43 (0.42, 0.46)	0.47 (0.47, 0.47)	NA (NA, NA)	0.48 (0.46, 0.48)	0.49 (0.49, 0.49)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.46 (0.43, 0.49)	0.49 (0.49, 0.49)	NA (NA, NA)	0.43 (0.41, 0.45)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.41 (0.31, 0.42)	0.37 (0.33, 0.43)	0.47 (0.43, 0.49)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC4	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.07 (0.07, 0.07)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
all	TC4	rate	0.261 (0.18, 0.292)	0.191 (0.051, 0.416)	0.278 (0.224, 0.332)	0.507 (0.373, 1.803)	0.41 (0.16, 0.792)	0.554 (0.411, 1.275)	1.098 (1.098, 1.098)	0.242 (0.204, 0.445)	0.064 (0.042, 0.094)	NA (NA, NA)	0.077 (0.05, 0.151)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	0 (0, 0.079)	0.283 (0.174, 0.392)	0 (0, 0)	0.289 (0.257, 0.32)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.492 (0.329, 1.792)	0.243 (0.166, 0.326)	0.05 (0.01, 0.314)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
AR- & TP53-	TC1	count	1	1	1	1					1	1	1	1
AR- & TP53-	TC1	time	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)					5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)
AR- & TP53-	TC1	n	24 (24, 24)	2 (2, 2)	0 (0, 0)	1 (1, 1)					0 (0, 0)	0 (0, 0)	1 (1, 1)	0 (0, 0)
AR- & TP53-	TC1	post_p	0.45 (0.45, 0.45)	0.42 (0.42, 0.42)	NA (NA, NA)	0.44 (0.44, 0.44)					NA (NA, NA)	NA (NA, NA)	0.49 (0.49, 0.49)	NA (NA, NA)
AR- & TP53-	TC1	r_prob	0.41 (0.41, 0.41)	0.22 (0.22, 0.22)	0.37 (0.37, 0.37)	0.22 (0.22, 0.22)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC1	rate	0.085 (0.085, 0.085)	0.295 (0.295, 0.295)	NA (NA, NA)	1.684 (1.684, 1.684)					NA (NA, NA)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)
AR- & TP53-	TC2	count	60	60	60	60					60	60	60	60
AR- & TP53-	TC2	time	18 (12, 32)	18 (12, 32)	18 (12, 32)	18 (12, 32)					18 (12, 32)	18 (12, 32)	18 (12, 32)	18 (12, 32)
AR- & TP53-	TC2	n	14 (9, 32)	5 (2, 8)	1 (0, 2)	3 (0, 6)					4 (2, 7)	0 (0, 0)	2 (0, 6)	1 (0, 3)
AR- & TP53-	TC2	post_p	0.09 (0.01, 0.33)	0.26 (0.1, 0.44)	0.44 (0.32, 0.49)	0.45 (0.37, 0.49)					0.31 (0.11, 0.45)	NA (NA, NA)	0.45 (0.31, 0.49)	0.45 (0.35, 0.49)
AR- & TP53-	TC2	r_prob	0.18 (0.18, 0.18)	0.03 (0.03, 0.03)	0.25 (0.25, 0.25)	0.03 (0.03, 0.03)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC2	rate	0.172 (0.13, 0.238)	0.195 (0.119, 0.561)	0.089 (0, 0.54)	0.107 (0.059, 0.386)					0.2 (0.101, 0.507)	0.341 (0.295, 0.386)	0.114 (0.056, 0.393)	0.082 (0, 0.591)
AR- & TP53-	TC3	count	19	19	19	19					19	19	19	19
AR- & TP53-	TC3	time	15 (11, 25)	15 (11, 25)	15 (11, 25)	15 (11, 25)					15 (11, 25)	15 (11, 25)	15 (11, 25)	15 (11, 25)
AR- & TP53-	TC3	n	14 (7, 35)	5 (1, 9)	1 (0, 2)	3 (1, 5)					6 (3, 10)	0 (0, 0)	4 (2, 8)	2 (0, 3)
AR- & TP53-	TC3	post_p	0.19 (0.05, 0.37)	0.37 (0.2, 0.44)	0.44 (0.34, 0.46)	0.41 (0.27, 0.46)					0.4 (0.28, 0.48)	NA (NA, NA)	0.44 (0.25, 0.47)	0.42 (0.36, 0.47)
AR- & TP53-	TC3	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
AR- & TP53-	TC3	rate	0.155 (0.125, 0.223)	0.182 (0.109, 0.547)	0.464 (0.093, 5.1)	0.157 (0.104, 0.389)					0.103 (0.059, 0.185)	NA (NA, NA)	0.088 (0.022, 0.245)	0.108 (0.044, 0.295)
AR- & TP53-	TC4	count	34	34	34	34					34	34	34	34
AR- & TP53-	TC4	time	16 (10, 20)	16 (10, 20)	16 (10, 20)	16 (10, 20)					16 (10, 20)	16 (10, 20)	16 (10, 20)	16 (10, 20)
AR- & TP53-	TC4	n	10 (5, 31)	4 (1, 6)	1 (0, 2)	2 (1, 4)					6 (2, 9)	0 (0, 0)	3 (1, 5)	2 (0, 4)
AR- & TP53-	TC4	post_p	0.15 (0.03, 0.3)	0.29 (0.16, 0.43)	0.42 (0.39, 0.48)	0.36 (0.21, 0.45)					0.45 (0.31, 0.49)	NA (NA, NA)	0.45 (0.36, 0.5)	0.45 (0.37, 0.49)
AR- & TP53-	TC4	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
AR- & TP53-	TC4	rate	0.198 (0.143, 0.423)	0.202 (0.127, 0.686)	0.278 (0.085, 1.11)	0.366 (0.1, 1.052)					0.085 (0.046, 0.236)	0 (0, 0)	0.077 (0, 0.196)	0.054 (0, 0.359)
AR- & TP53-	TC5	count	3	3	3	3					3	3	3	3
AR- & TP53-	TC5	time	12 (10, 18)	12 (10, 18)	12 (10, 18)	12 (10, 18)					12 (10, 18)	12 (10, 18)	12 (10, 18)	12 (10, 18)
AR- & TP53-	TC5	n	13 (7, 14)	3 (1, 6)	1 (0, 1)	3 (1, 7)					5 (4, 7)	0 (0, 0)	2 (0, 4)	1 (0, 2)
AR- & TP53-	TC5	post_p	0.36 (0.1, 0.4)	0.44 (0.41, 0.47)	0.42 (0.42, 0.42)	0.46 (0.45, 0.48)					0.19 (0.1, 0.35)	NA (NA, NA)	0.34 (0.26, 0.42)	0.45 (0.45, 0.45)
AR- & TP53-	TC5	r_prob	0 (0, 0)	0.38 (0.38, 0.38)	0 (0, 0)	0.38 (0.38, 0.38)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC5	rate	0.155 (0.129, 0.344)	0.145 (0.125, 2.303)	4.845 (0.969, 8.72)	0.067 (0.04, 0.095)					0.382 (0.192, 0.582)	NA (NA, NA)	0.245 (0.192, 0.298)	0.113 (0.023, 0.204)
HRD+	TC1	count									2	2	2	2	2	2	2	2									2	2	2	2	2	2	2	2
HRD+	TC1	time									32 (31, 34)	32 (31, 34)	32 (31, 34)	32 (31, 34)	32 (31, 34)	32 (31, 34)	32 (31, 34)	32 (31, 34)									32 (31, 34)	32 (31, 34)	32 (31, 34)	32 (31, 34)	32 (31, 34)	32 (31, 34)	32 (31, 34)	32 (31, 34)
HRD+	TC1	n									6 (6, 7)	0 (0, 0)	6 (4, 8)	4 (2, 6)	0 (0, 0)	3 (3, 3)	0 (0, 0)	2 (0, 4)									4 (3, 4)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 1)	0 (0, 1)	0 (0, 0)	0 (0, 0)
HRD+	TC1	post_p									0.34 (0.24, 0.45)	NA (NA, NA)	0.34 (0.26, 0.43)	0.27 (0.23, 0.31)	NA (NA, NA)	0.37 (0.35, 0.4)	NA (NA, NA)	0.44 (0.44, 0.44)									0.25 (0.23, 0.26)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC1	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC1	rate									0.102 (0.084, 0.119)	NA (NA, NA)	0.098 (0.096, 0.099)	0.149 (0.142, 0.156)	NA (NA, NA)	0.4 (0.218, 0.582)	NA (NA, NA)	0.12 (0.12, 0.12)									0.196 (0.188, 0.204)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0.494 (0.494, 0.494)	NA (NA, NA)	NA (NA, NA)
HRD+	TC2	count									19	19	19	19	19	19	19	19									19	19	19	19	19	19	19	19
HRD+	TC2	time									35 (26, 35)	35 (26, 35)	35 (26, 35)	35 (26, 35)	35 (26, 35)	35 (26, 35)	35 (26, 35)	35 (26, 35)									35 (26, 35)	35 (26, 35)	35 (26, 35)	35 (26, 35)	35 (26, 35)	35 (26, 35)	35 (26, 35)	35 (26, 35)
HRD+	TC2	n									8 (6, 11)	0 (0, 0)	7 (6, 10)	3 (1, 5)	0 (0, 0)	2 (1, 4)	0 (0, 0)	2 (0, 4)									4 (2, 6)	0 (0, 0)	0 (0, 2)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC2	post_p									0.14 (0.07, 0.28)	NA (NA, NA)	0.4 (0.3, 0.48)	0.39 (0.33, 0.48)	NA (NA, NA)	0.39 (0.25, 0.45)	NA (NA, NA)	0.42 (0.37, 0.47)									0.3 (0.16, 0.43)	NA (NA, NA)	0.48 (0.33, 0.49)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC2	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC2	rate									0.2 (0.132, 0.507)	NA (NA, NA)	0.088 (0.062, 0.127)	0.103 (0.06, 0.379)	0.43 (0.43, 0.43)	0.496 (0.152, 1.385)	NA (NA, NA)	0.175 (0.078, 1.285)									0.195 (0.133, 0.394)	0.046 (0.009, 0.083)	0.128 (0.102, 3.621)	0.094 (0.094, 0.094)	0.26 (0.07, 0.795)	NA (NA, NA)	0.056 (0.011, 0.101)	NA (NA, NA)
HRD+	TC5	count									10	10	10	10	10	10	10	10									10	10	10	10	10	10	10	10
HRD+	TC5	time									32 (30, 35)	32 (30, 35)	32 (30, 35)	32 (30, 35)	32 (30, 35)	32 (30, 35)	32 (30, 35)	32 (30, 35)									32 (30, 35)	32 (30, 35)	32 (30, 35)	32 (30, 35)	32 (30, 35)	32 (30, 35)	32 (30, 35)	32 (30, 35)
HRD+	TC5	n									14 (8, 16)	0 (0, 1)	5 (3, 8)	1 (0, 3)	0 (0, 0)	0 (0, 2)	0 (0, 0)	0 (0, 3)									4 (2, 8)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC5	post_p									0.14 (0.07, 0.35)	NA (NA, NA)	0.18 (0.08, 0.33)	0.42 (0.38, 0.47)	NA (NA, NA)	0.37 (0.33, 0.4)	NA (NA, NA)	0.48 (0.44, 0.5)									0.28 (0.11, 0.34)	NA (NA, NA)	0.48 (0.47, 0.49)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC5	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC5	rate									0.195 (0.123, 0.256)	0.037 (0.007, 0.066)	0.228 (0.177, 0.516)	0.092 (0.067, 0.143)	NA (NA, NA)	0.219 (0.021, 0.567)	NA (NA, NA)	0.063 (0.038, 0.128)									0.261 (0.152, 0.594)	NA (NA, NA)	0.366 (0.174, 0.799)	NA (NA, NA)	0.378 (0.378, 0.378)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC1	count					122	122	122	122					122	122	122	122					122	122	122	122					122	122	122	122
TP53+	TC1	time					24 (16, 32)	24 (16, 32)	24 (16, 32)	24 (16, 32)					24 (16, 32)	24 (16, 32)	24 (16, 32)	24 (16, 32)					24 (16, 32)	24 (16, 32)	24 (16, 32)	24 (16, 32)					24 (16, 32)	24 (16, 32)	24 (16, 32)	24 (16, 32)
TP53+	TC1	n					7 (4, 15)	6 (2, 12)	2 (1, 5)	4 (2, 10)					0 (0, 0)	1 (0, 3)	0 (0, 0)	1 (0, 3)					0 (0, 2)	0 (0, 0)	4 (2, 10)	4 (2, 10)					0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC1	post_p					0.36 (0.15, 0.48)	0.33 (0.17, 0.47)	0.43 (0.29, 0.49)	0.33 (0.15, 0.46)					NA (NA, NA)	0.43 (0.29, 0.48)	NA (NA, NA)	0.42 (0.33, 0.48)					0.46 (0.37, 0.5)	NA (NA, NA)	0.3 (0.15, 0.47)	0.33 (0.16, 0.47)					0.45 (0.44, 0.48)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC1	r_prob					0.31 (0.31, 0.31)	0.13 (0.13, 0.13)	0.18 (0.18, 0.18)	0.09 (0.09, 0.09)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.12 (0.12, 0.12)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.07 (0.07, 0.07)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC1	rate					0.144 (0.101, 0.333)	0.181 (0.128, 0.518)	0.15 (0.095, 0.632)	0.158 (0.092, 0.356)					0.078 (0.016, 0.141)	0.205 (0.066, 0.857)	0 (0, 0.406)	0.207 (0.066, 0.755)					0.174 (0, 0.937)	0 (0, 0.443)	0.177 (0.115, 0.417)	0.168 (0.096, 0.448)					0.239 (0, 0.787)	0.159 (0.102, 0.217)	0.102 (0.02, 0.76)	NA (NA, NA)
TP53+	TC3	count					87	87	87	87					87	87	87	87					87	87	87	87					87	87	87	87
TP53+	TC3	time					24 (17, 33)	24 (17, 33)	24 (17, 33)	24 (17, 33)					24 (17, 33)	24 (17, 33)	24 (17, 33)	24 (17, 33)					24 (17, 33)	24 (17, 33)	24 (17, 33)	24 (17, 33)					24 (17, 33)	24 (17, 33)	24 (17, 33)	24 (17, 33)
TP53+	TC3	n					7 (4, 13)	5 (3, 10)	2 (0, 4)	4 (1, 7)					0 (0, 0)	1 (0, 3)	0 (0, 0)	1 (0, 2)					0 (0, 2)	0 (0, 0)	5 (2, 9)	4 (2, 7)					0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC3	post_p					0.37 (0.16, 0.48)	0.33 (0.16, 0.47)	0.4 (0.25, 0.48)	0.3 (0.13, 0.45)					NA (NA, NA)	0.47 (0.39, 0.5)	NA (NA, NA)	0.47 (0.41, 0.5)					0.45 (0.29, 0.49)	NA (NA, NA)	0.3 (0.15, 0.43)	0.28 (0.13, 0.44)					0.48 (0.48, 0.48)	NA (NA, NA)	0.5 (0.5, 0.5)	NA (NA, NA)
TP53+	TC3	r_prob					0.07 (0.07, 0.07)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TP53+	TC3	rate					0.14 (0.099, 0.279)	0.207 (0.135, 0.384)	0.218 (0.122, 0.667)	0.185 (0.111, 0.624)					0 (0, 0)	0.07 (0, 0.223)	0 (0, 0)	0.079 (0, 0.285)					0.256 (0, 0.543)	0.169 (0.034, 0.384)	0.179 (0.116, 0.509)	0.212 (0.131, 0.536)					0.11 (0, 0.285)	0.286 (0.286, 0.286)	0.042 (0.042, 0.042)	0.103 (0.021, 0.185)
TP53+	TC4	count					126	126	126	126					126	126	126	126					126	126	126	126					126	126	126	126
TP53+	TC4	time					24 (16, 32)	24 (16, 32)	24 (16, 32)	24 (16, 32)					24 (16, 32)	24 (16, 32)	24 (16, 32)	24 (16, 32)					24 (16, 32)	24 (16, 32)	24 (16, 32)	24 (16, 32)					24 (16, 32)	24 (16, 32)	24 (16, 32)	24 (16, 32)
TP53+	TC4	n					7 (3, 12)	5 (2, 10)	2 (0, 4)	3 (2, 6)					0 (0, 0)	1 (0, 3)	0 (0, 0)	1 (0, 3)					0 (0, 2)	0 (0, 0)	4 (2, 7)	3 (2, 6)					0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC4	post_p					0.37 (0.15, 0.48)	0.26 (0.13, 0.45)	0.4 (0.2, 0.47)	0.27 (0.1, 0.43)					NA (NA, NA)	0.46 (0.4, 0.49)	NA (NA, NA)	0.45 (0.39, 0.49)					0.44 (0.34, 0.49)	NA (NA, NA)	0.23 (0.11, 0.41)	0.23 (0.11, 0.39)					0.49 (0.49, 0.49)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC4	r_prob					0.07 (0.07, 0.07)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TP53+	TC4	rate					0.151 (0.105, 0.295)	0.239 (0.153, 0.631)	0.262 (0.13, 1.032)	0.255 (0.129, 0.697)					0 (0, 0.047)	0.071 (0, 0.278)	0 (0, 0)	0.079 (0, 0.242)					0.284 (0.033, 1.319)	0.09 (0.035, 0.839)	0.267 (0.135, 0.708)	0.248 (0.13, 0.57)					0 (0, 0.156)	0 (0, 0)	0 (0, 0.052)	0 (0, 0)
TEfus+	TC1	count			46	46			46	46			46	46			46	46			46	46			46	46			46	46			46	46
TEfus+	TC1	time			27 (18, 35)	27 (18, 35)			27 (18, 35)	27 (18, 35)			27 (18, 35)	27 (18, 35)			27 (18, 35)	27 (18, 35)			27 (18, 35)	27 (18, 35)			27 (18, 35)	27 (18, 35)			27 (18, 35)	27 (18, 35)			27 (18, 35)	27 (18, 35)
TEfus+	TC1	n			1 (0, 4)	2 (0, 8)			2 (1, 5)	5 (2, 10)			1 (0, 8)	1 (0, 3)			0 (0, 0)	1 (0, 3)			3 (1, 6)	2 (0, 4)			4 (2, 11)	4 (2, 10)			0 (0, 2)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC1	post_p			0.44 (0.35, 0.49)	0.42 (0.29, 0.48)			0.38 (0.26, 0.48)	0.3 (0.1, 0.45)			0.39 (0.25, 0.49)	0.44 (0.35, 0.48)			NA (NA, NA)	0.41 (0.28, 0.48)			0.38 (0.22, 0.47)	0.38 (0.32, 0.48)			0.28 (0.13, 0.44)	0.36 (0.2, 0.45)			0.42 (0.35, 0.5)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC1	r_prob			0.37 (0.37, 0.37)	0.22 (0.22, 0.22)			0.18 (0.18, 0.18)	0.09 (0.09, 0.09)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.18 (0.18, 0.18)	0.14 (0.14, 0.14)			0.12 (0.12, 0.12)	0.07 (0.07, 0.07)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC1	rate			0.129 (0.06, 0.498)	0.098 (0.058, 0.205)			0.197 (0.101, 0.753)	0.164 (0.105, 0.374)			0.107 (0.064, 0.393)	0.12 (0.043, 0.312)			NA (NA, NA)	0.204 (0.083, 1.011)			0.174 (0.103, 0.327)	0.232 (0.116, 0.689)			0.178 (0.119, 0.354)	0.156 (0.109, 0.315)			0.223 (0.072, 0.319)	NA (NA, NA)			0.107 (0.107, 0.107)	0.418 (0.315, 0.521)
TEfus+	TC3	count			34	34			34	34			34	34			34	34			34	34			34	34			34	34			34	34
TEfus+	TC3	time			21 (15, 30)	21 (15, 30)			21 (15, 30)	21 (15, 30)			21 (15, 30)	21 (15, 30)			21 (15, 30)	21 (15, 30)			21 (15, 30)	21 (15, 30)			21 (15, 30)	21 (15, 30)			21 (15, 30)	21 (15, 30)			21 (15, 30)	21 (15, 30)
TEfus+	TC3	n			1 (0, 3)	3 (2, 7)			2 (1, 4)	3 (1, 6)			4 (2, 7)	1 (0, 4)			0 (0, 0)	1 (0, 2)			2 (1, 6)	1 (0, 3)			4 (2, 10)	4 (2, 8)			0 (0, 1)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC3	post_p			0.44 (0.37, 0.49)	0.32 (0.17, 0.47)			0.41 (0.3, 0.47)	0.31 (0.15, 0.42)			0.4 (0.27, 0.46)	0.44 (0.35, 0.49)			NA (NA, NA)	0.45 (0.4, 0.48)			0.43 (0.32, 0.48)	0.42 (0.29, 0.48)			0.35 (0.14, 0.42)	0.35 (0.15, 0.45)			0.42 (0.42, 0.42)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC3	r_prob			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0 (0, 0)	0 (0, 0)			0.06 (0.06, 0.06)	0.07 (0.07, 0.07)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TEfus+	TC3	rate			0.232 (0.078, 3.044)	0.173 (0.105, 0.447)			0.237 (0.13, 0.518)	0.203 (0.109, 1.023)			0.09 (0.063, 0.3)	0.091 (0.011, 0.339)			0.061 (0.061, 0.061)	0.078 (0, 0.245)			0.206 (0.113, 0.442)	0.178 (0.077, 0.61)			0.175 (0.115, 0.374)	0.155 (0.096, 0.348)			0 (0, 0.147)	0.326 (0.326, 0.326)			0 (0, 0)	NA (NA, NA)
TEfus+	TC4	count			75	75			75	75			75	75			75	75			75	75			75	75			75	75			75	75
TEfus+	TC4	time			22 (15, 31)	22 (15, 31)			22 (15, 31)	22 (15, 31)			22 (15, 31)	22 (15, 31)			22 (15, 31)	22 (15, 31)			22 (15, 31)	22 (15, 31)			22 (15, 31)	22 (15, 31)			22 (15, 31)	22 (15, 31)			22 (15, 31)	22 (15, 31)
TEfus+	TC4	n			1 (0, 3)	3 (1, 6)			2 (0, 4)	3 (2, 7)			4 (2, 7)	2 (0, 4)			0 (0, 0)	1 (0, 3)			2 (1, 4)	1 (0, 4)			4 (1, 6)	4 (2, 7)			0 (0, 1)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC4	post_p			0.38 (0.3, 0.46)	0.28 (0.16, 0.43)			0.38 (0.23, 0.46)	0.28 (0.13, 0.41)			0.44 (0.28, 0.5)	0.44 (0.34, 0.5)			0.47 (0.47, 0.47)	0.45 (0.39, 0.49)			0.39 (0.18, 0.48)	0.39 (0.26, 0.46)			0.27 (0.11, 0.47)	0.24 (0.1, 0.44)			0.48 (0.44, 0.49)	NA (NA, NA)			NA (NA, NA)	0.44 (0.44, 0.44)
TEfus+	TC4	r_prob			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0 (0, 0)	0 (0, 0)			0.06 (0.06, 0.06)	0.07 (0.07, 0.07)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TEfus+	TC4	rate			0.279 (0.144, 1.078)	0.276 (0.133, 0.894)			0.257 (0.143, 0.865)	0.212 (0.12, 0.513)			0.078 (0.036, 0.192)	0.067 (0.023, 0.295)			0.099 (0.02, 0.68)	0.079 (0, 0.245)			0.249 (0.111, 0.915)	0.277 (0.131, 1.47)			0.252 (0.136, 0.658)	0.24 (0.123, 0.524)			0.068 (0, 0.573)	0 (0, 0)			NA (NA, NA)	0.08 (0.016, 0.144)
TEfus+	TC5	count			2	2			2	2			2	2			2	2			2	2			2	2			2	2			2	2
TEfus+	TC5	time			12 (12, 13)	12 (12, 13)			12 (12, 13)	12 (12, 13)			12 (12, 13)	12 (12, 13)			12 (12, 13)	12 (12, 13)			12 (12, 13)	12 (12, 13)			12 (12, 13)	12 (12, 13)			12 (12, 13)	12 (12, 13)			12 (12, 13)	12 (12, 13)
TEfus+	TC5	n			0 (0, 1)	4 (3, 5)			0 (0, 1)	6 (4, 7)			2 (0, 4)	0 (0, 1)			0 (0, 0)	2 (0, 3)			3 (3, 3)	1 (1, 1)			2 (2, 3)	4 (3, 6)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC5	post_p			NA (NA, NA)	0.48 (0.47, 0.49)			0.43 (0.43, 0.43)	0.46 (0.45, 0.46)			0.42 (0.42, 0.42)	0.42 (0.42, 0.42)			NA (NA, NA)	0.47 (0.47, 0.47)			0.42 (0.41, 0.43)	0.42 (0.42, 0.42)			0.35 (0.26, 0.44)	0.43 (0.38, 0.48)			NA (NA, NA)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC5	r_prob			0 (0, 0)	0.38 (0.38, 0.38)			0 (0, 0)	0.38 (0.38, 0.38)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0.29 (0.29, 0.29)			0 (0, 0)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC5	rate			1.586 (1.586, 1.586)	0.077 (0.063, 0.09)			15.262 (15.262, 15.262)	0.092 (0.084, 0.1)			0.185 (0.185, 0.185)	0.523 (0.523, 0.523)			NA (NA, NA)	0.135 (0.135, 0.135)			0.193 (0.143, 0.244)	0.285 (0.274, 0.296)			0.244 (0.169, 0.319)	0.118 (0.105, 0.13)			NA (NA, NA)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
PI3K+	TC1	count		13		13		13		13		13		13		13		13		13		13		13		13		13		13		13		13
PI3K+	TC1	time		23 (15, 33)		23 (15, 33)		23 (15, 33)		23 (15, 33)		23 (15, 33)		23 (15, 33)		23 (15, 33)		23 (15, 33)		23 (15, 33)		23 (15, 33)		23 (15, 33)		23 (15, 33)		23 (15, 33)		23 (15, 33)		23 (15, 33)		23 (15, 33)
PI3K+	TC1	n		5 (2, 10)		3 (1, 6)		7 (3, 15)		4 (0, 7)		0 (0, 0)		1 (0, 3)		1 (0, 2)		1 (0, 3)		0 (0, 2)		1 (0, 4)		0 (0, 0)		4 (2, 5)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC1	post_p		0.37 (0.27, 0.46)		0.36 (0.25, 0.42)		0.34 (0.27, 0.46)		0.36 (0.11, 0.44)		NA (NA, NA)		0.44 (0.4, 0.48)		0.45 (0.41, 0.46)		0.41 (0.33, 0.45)		0.38 (0.33, 0.46)		0.43 (0.3, 0.44)		NA (NA, NA)		0.31 (0.17, 0.43)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC1	r_prob		0.22 (0.22, 0.22)		0.22 (0.22, 0.22)		0.13 (0.13, 0.13)		0.09 (0.09, 0.09)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.14 (0.14, 0.14)		0.14 (0.14, 0.14)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC1	rate		0.142 (0.107, 0.177)		0.125 (0.078, 0.181)		0.18 (0.135, 0.354)		0.188 (0.104, 0.419)		NA (NA, NA)		0.084 (0.047, 0.349)		0.278 (0.198, 0.685)		0.2 (0.121, 2.371)		0.149 (0.051, 1.82)		0.31 (0.111, 0.751)		NA (NA, NA)		0.156 (0.113, 0.586)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC2	count		3		3		3		3		3		3		3		3		3		3		3		3		3		3		3		3
PI3K+	TC2	time		29 (18, 33)		29 (18, 33)		29 (18, 33)		29 (18, 33)		29 (18, 33)		29 (18, 33)		29 (18, 33)		29 (18, 33)		29 (18, 33)		29 (18, 33)		29 (18, 33)		29 (18, 33)		29 (18, 33)		29 (18, 33)		29 (18, 33)		29 (18, 33)
PI3K+	TC2	n		6 (4, 6)		4 (1, 5)		4 (2, 8)		4 (2, 8)		0 (0, 0)		1 (0, 1)		1 (0, 1)		2 (0, 2)		1 (0, 1)		1 (0, 3)		0 (0, 0)		3 (2, 5)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC2	post_p		0.21 (0.21, 0.22)		0.37 (0.34, 0.4)		0.34 (0.18, 0.36)		0.46 (0.45, 0.47)		NA (NA, NA)		0.44 (0.4, 0.48)		0.46 (0.45, 0.46)		0.45 (0.42, 0.48)		0.4 (0.39, 0.41)		0.42 (0.4, 0.43)		NA (NA, NA)		0.32 (0.28, 0.41)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC2	r_prob		0.03 (0.03, 0.03)		0.03 (0.03, 0.03)		0.07 (0.07, 0.07)		0.16 (0.16, 0.16)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0.21 (0.21, 0.21)		0.21 (0.21, 0.21)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC2	rate		0.219 (0.136, 0.338)		0.082 (0.073, 0.092)		0.226 (0.209, 0.247)		0.106 (0.071, 0.118)		NA (NA, NA)		0.117 (0.091, 0.143)		1.509 (0.595, 2.423)		0.106 (0.093, 0.118)		1.194 (0.697, 1.692)		0.14 (0.094, 0.186)		NA (NA, NA)		0.197 (0.143, 0.314)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC3	count		75		75		75		75		75		75		75		75		75		75		75		75		75		75		75		75
PI3K+	TC3	time		23 (17, 31)		23 (17, 31)		23 (17, 31)		23 (17, 31)		23 (17, 31)		23 (17, 31)		23 (17, 31)		23 (17, 31)		23 (17, 31)		23 (17, 31)		23 (17, 31)		23 (17, 31)		23 (17, 31)		23 (17, 31)		23 (17, 31)		23 (17, 31)
PI3K+	TC3	n		6 (2, 12)		4 (1, 7)		5 (3, 10)		4 (2, 7)		0 (0, 0)		2 (0, 4)		1 (0, 3)		1 (0, 2)		0 (0, 2)		1 (0, 3)		0 (0, 0)		3 (2, 6)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC3	post_p		0.27 (0.12, 0.45)		0.3 (0.15, 0.46)		0.33 (0.14, 0.46)		0.29 (0.14, 0.46)		NA (NA, NA)		0.46 (0.39, 0.5)		0.48 (0.41, 0.5)		0.46 (0.38, 0.49)		0.44 (0.34, 0.48)		0.43 (0.34, 0.48)		NA (NA, NA)		0.29 (0.13, 0.44)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC3	r_prob		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC3	rate		0.177 (0.104, 0.394)		0.171 (0.088, 0.531)		0.201 (0.142, 0.394)		0.179 (0.102, 0.573)		0 (0, 0)		0.068 (0.023, 0.11)		0.1 (0, 0.845)		0.079 (0, 0.244)		0.263 (0.066, 0.548)		0.208 (0.081, 0.722)		4.319 (0.999, 7.639)		0.213 (0.107, 0.56)		0.117 (0.023, 0.21)		0.625 (0.125, 1.125)		0.054 (0, 0.175)		0.156 (0.031, 0.195)
PI3K+	TC4	count		104		104		104		104		104		104		104		104		104		104		104		104		104		104		104		104
PI3K+	TC4	time		22 (16, 33)		22 (16, 33)		22 (16, 33)		22 (16, 33)		22 (16, 33)		22 (16, 33)		22 (16, 33)		22 (16, 33)		22 (16, 33)		22 (16, 33)		22 (16, 33)		22 (16, 33)		22 (16, 33)		22 (16, 33)		22 (16, 33)		22 (16, 33)
PI3K+	TC4	n		5 (2, 10)		3 (1, 6)		5 (2, 10)		3 (1, 6)		0 (0, 0)		2 (0, 4)		1 (0, 3)		1 (0, 3)		1 (0, 2)		2 (0, 3)		0 (0, 0)		4 (2, 6)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC4	post_p		0.22 (0.07, 0.4)		0.28 (0.13, 0.42)		0.25 (0.12, 0.46)		0.25 (0.12, 0.41)		NA (NA, NA)		0.46 (0.35, 0.49)		0.47 (0.42, 0.49)		0.47 (0.41, 0.5)		0.44 (0.37, 0.49)		0.39 (0.26, 0.46)		NA (NA, NA)		0.26 (0.12, 0.44)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC4	r_prob		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC4	rate		0.219 (0.125, 0.494)		0.237 (0.115, 0.64)		0.256 (0.143, 0.616)		0.244 (0.129, 0.756)		0.067 (0.013, 0.12)		0.078 (0.024, 0.279)		0.069 (0, 0.268)		0.073 (0, 0.288)		0.305 (0.09, 0.987)		0.318 (0.156, 1.591)		0.567 (0.169, 0.966)		0.226 (0.121, 0.446)		0 (0, 0.18)		0 (0, 0)		NA (NA, NA)		0 (0, 0)